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Cecilia J. Hillard PhD

Cecilia J. Hillard PhD profile photo picture

Associate Dean, Center Director, Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Director of the Neuroscience Research Center
Member of the Cancer Center
Member of the Center for Disease Prevention Research (CDPR)
Member of the Comprehensive Injury Center


Research Experience

  • Anxiety
  • Brain
  • Cannabidiol
  • Cannabinoid Receptor Agonists
  • Cannabinoid Receptor Modulators
  • Cannabinoids
  • Carrier Proteins
  • Cells, Cultured
  • Cocaine
  • Corticosterone
  • Depression
  • Endocannabinoids
  • Mice
  • Microglia
  • Models, Animal
  • Neurons
  • Obesity
  • Rats, Sprague-Dawley
  • Receptor, Cannabinoid, CB1
  • Receptor, Cannabinoid, CB2
  • Receptors, Cannabinoid
  • Receptors, Drug
  • Restraint, Physical
  • Signal Transduction
  • Stress, Physiological
  • Stress, Psychological
  • Publications (229)

  • Circulating endocannabinoid concentrations in grieving adults (Harfmann EJ, McAuliffe TL, Larson ER, Claesges SA, Sauber G, Hillard CJ, Goveas JS) Psychoneuroendocrinology October 2020;120 SCOPUS ID: 2-s2.0-85087803094 10/01/2020    
  • Meet Your Stress Management Professionals: The Endocannabinoids. (deRoon-Cassini TA, Stollenwerk TM, Beatka M, Hillard CJ) Trends Mol Med 2020 Aug 28 PMID: 32868170 SCOPUS ID: 2-s2.0-85089963030 09/02/2020    
  • Hot-Water Bathing Improves Symptoms in Patients with Cyclic Vomiting Syndrome and Is Modulated by Chronic Cannabis Use. (Rosen S, Diaz R, Garacci Z, Kumar VCS, Thyarala SR, Hillard CJ, Venkatesan T) Dig Dis Sci 2020 May 29 PMID: 32472256 SCOPUS ID: 2-s2.0-85085560520 05/31/2020    
  • Adverse maternal environment and western diet impairs cognitive function and alters hippocampal glucocorticoid receptor promoter methylation in male mice. (Ke X, Fu Q, Sterrett J, Hillard CJ, Lane RH, Majnik A) Physiol Rep 2020 04;8(8):e14407 PMID: 32333646 PMCID: PMC7183239 SCOPUS ID: 2-s2.0-85084031438 04/26/2020    
  • Sex, stress, and prefrontal cortex: influence of biological sex on stress-promoted cocaine seeking. (Doncheck EM, Liddiard GT, Konrath CD, Liu X, Yu L, Urbanik LA, Herbst MR, DeBaker MC, Raddatz N, Van Newenhizen EC, Mathy J, Gilmartin MR, Liu QS, Hillard CJ, Mantsch JR) Neuropsychopharmacology 2020 Apr 17 PMID: 32303052 SCOPUS ID: 2-s2.0-85084141235 04/18/2020       1 Citation
  • Circadian Misalignment of the 24-hour Profile of Endocannabinoid 2-Arachidonoylglycerol (2-AG) in Obese Adults. (Hanlon EC, Leproult R, Stuhr KL, Doncheck EM, Hillard CJ, Van Cauter E) J Clin Endocrinol Metab 2020 Mar 01;105(3) PMID: 31970413 PMCID: PMC7015463 SCOPUS ID: 2-s2.0-85079347809 01/24/2020       2 Citations
  • Antidepressant-like effects of URB597 and JZL184 in male and female rats exposed to early life stress (Alteba S, Mizrachi Zer-Aviv T, Tenenhaus A, Ben David G, Adelman J, Hillard CJ, Doron R, Akirav I) European Neuropsychopharmacology 2020 SCOPUS ID: 2-s2.0-85090150762 01/01/2020    
  • Stress-induced modulation of endocannabinoid signaling leads to delayed strengthening of synaptic connectivity in the amygdala. (Yasmin F, Colangeli R, Morena M, Filipski S, van der Stelt M, Pittman QJ, Hillard CJ, Teskey GC, McEwen BS, Hill MN, Chattarji S) Proc Natl Acad Sci U S A 2020 01 07;117(1):650-655 PMID: 31843894 PMCID: PMC6955336 SCOPUS ID: 2-s2.0-85077654645 12/18/2019       3 Citations
  • Psychological and endocannabinoid responses to aerobic exercise in substance use disorder patients. (Brellenthin AG, Crombie KM, Hillard CJ, Brown RT, Koltyn KF) Subst Abus 2019 Nov 15:1-12 PMID: 31729933 PMCID: PMC7225058 11/16/2019    
  • Patterns of Cannabis Use in Patients With Cyclic Vomiting Syndrome. (Venkatesan T, Hillard CJ, Rein L, Banerjee A, Lisdahl K) Clin Gastroenterol Hepatol 2020 May;18(5):1082-1090.e2 PMID: 31352091 SCOPUS ID: 2-s2.0-85081912688 07/29/2019    
  • Loss of exercise- and stress-induced increases in circulating 2-arachidonoylglycerol concentrations in adults with chronic PTSD. (Crombie KM, Leitzelar BN, Brellenthin AG, Hillard CJ, Koltyn KF) Biol Psychol 2019 07;145:1-7 PMID: 30978371 SCOPUS ID: 2-s2.0-85064154072 04/13/2019       6 Citations
  • Serum Endocannabinoid and Mood Changes after Exercise in Major Depressive Disorder. (Meyer JD, Crombie KM, Cook DB, Hillard CJ, Koltyn KF) Med Sci Sports Exerc 2019 09;51(9):1909-1917 PMID: 30973483 PMCID: PMC6727944 SCOPUS ID: 2-s2.0-85070841260 04/12/2019       10 Citations
  • Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing. (Murataeva N, Miller S, Dhopeshwarkar A, Leishman E, Daily L, Taylor X, Morton B, Lashmet M, Bradshaw H, Hillard CJ, Romero J, Straiker A) Exp Eye Res 2019 05;182:74-84 PMID: 30905716 PMCID: PMC6504573 SCOPUS ID: 2-s2.0-85063275776 03/25/2019       5 Citations
  • Early life stress alters the developmental trajectory of corticolimbic endocannabinoid signaling in male rats. (Hill MN, Eiland L, Lee TTY, Hillard CJ, McEwen BS) Neuropharmacology 2019 03 01;146:154-162 PMID: 30496752 PMCID: PMC6347425 SCOPUS ID: 2-s2.0-85057629348 11/30/2018       11 Citations
  • Recent trends in cyclic vomiting syndrome-associated hospitalisations with liberalisation of cannabis use in the state of Colorado. (Bhandari S, Jha P, Lisdahl KM, Hillard CJ, Venkatesan T) Intern Med J 2019 05;49(5):649-655 PMID: 30426628 SCOPUS ID: 2-s2.0-85065707659 11/15/2018       8 Citations
  • Revisiting cannabinoid receptor 2 expression and function in murine retina. (Borowska-Fielding J, Murataeva N, Smith B, Szczesniak AM, Leishman E, Daily L, Toguri JT, Hillard CJ, Romero J, Bradshaw H, Kelly MEM, Straiker A) Neuropharmacology 2018 10;141:21-31 PMID: 30121200 PMCID: PMC6314309 SCOPUS ID: 2-s2.0-85053042908 08/20/2018    
  • Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity. (Segev A, Korem N, Mizrachi Zer-Aviv T, Abush H, Lange R, Sauber G, Hillard CJ, Akirav I) Neuropsychopharmacology 2018 09;43(10):2017-2027 PMID: 29977073 PMCID: PMC6098035 SCOPUS ID: 2-s2.0-85049559833 07/07/2018       17 Citations
  • Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. (Balsevich G, Sticht M, Bowles NP, Singh A, Lee TTY, Li Z, Chelikani PK, Lee FS, Borgland SL, Hillard CJ, McEwen BS, Hill MN) Proc Natl Acad Sci U S A 2018 07 17;115(29):7605-7610 PMID: 29967158 PMCID: PMC6055171 SCOPUS ID: 2-s2.0-85049982499 07/04/2018       5 Citations
  • The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System. (Berger AL, Henricks AM, Lugo JM, Wright HR, Warrick CR, Sticht MA, Morena M, Bonilla I, Laredo SA, Craft RM, Parsons LH, Grandes PR, Hillard CJ, Hill MN, McLaughlin RJ) Biol Psychiatry 2018 10 15;84(8):611-623 PMID: 29887035 PMCID: PMC6162143 SCOPUS ID: 2-s2.0-85048097931 06/12/2018       7 Citations
  • Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer's disease. (López A, Aparicio N, Pazos MR, Grande MT, Barreda-Manso MA, Benito-Cuesta I, Vázquez C, Amores M, Ruiz-Pérez G, García-García E, Beatka M, Tolón RM, Dittel BN, Hillard CJ, Romero J) J Neuroinflammation 2018 May 24;15(1):158 PMID: 29793509 PMCID: PMC5968596 SCOPUS ID: 2-s2.0-85047540052 05/26/2018       24 Citations
  • Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD. (Fidelman S, Mizrachi Zer-Aviv T, Lange R, Hillard CJ, Akirav I) Eur Neuropsychopharmacol 2018 05;28(5):630-642 PMID: 29519609 SCOPUS ID: 2-s2.0-85042367663 03/10/2018       19 Citations
  • Psychobiological Responses to Aerobic Exercise in Individuals With Posttraumatic Stress Disorder. (Crombie KM, Brellenthin AG, Hillard CJ, Koltyn KF) J Trauma Stress 2018 02;31(1):134-145 PMID: 29388710 SCOPUS ID: 2-s2.0-85043318022 02/02/2018       13 Citations
  • Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex. (McReynolds JR, Doncheck EM, Li Y, Vranjkovic O, Graf EN, Ogasawara D, Cravatt BF, Baker DA, Liu QS, Hillard CJ, Mantsch JR) Biol Psychiatry 2018 07 15;84(2):85-94 PMID: 29100630 PMCID: PMC5889367 SCOPUS ID: 2-s2.0-85033680278 11/05/2017       11 Citations
  • Increase in the circulating endocannabinoid 2-arachidonoylglycerol is associated with gabapentin use in septic ICU patients. (Raff H, Kramer DJ, Hillard CJ) Endocrine 2017 10;58(1):203-204 PMID: 28875451 SCOPUS ID: 2-s2.0-85028974393 09/07/2017    
  • 17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors. (Doncheck EM, Urbanik LA, DeBaker MC, Barron LM, Liddiard GT, Tuscher JJ, Frick KM, Hillard CJ, Mantsch JR) Neuropsychopharmacology 2018 03;43(4):781-790 PMID: 28825421 PMCID: PMC5809785 SCOPUS ID: 2-s2.0-85041731033 08/22/2017       8 Citations
  • Endocannabinoid Transport Proteins: Discovery of Tools to Study Sterol Carrier Protein-2. (Hillard CJ, Huang H, Vogt CD, Rodrigues BE, Neumann TS, Sem DS, Schroeder F, Cunningham CW) Methods Enzymol 2017;593:99-121 PMID: 28750817 PMCID: PMC6904209 SCOPUS ID: 2-s2.0-85024124936 07/29/2017       9 Citations
  • Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice. (Helfand AI, Olsen CM, Hillard CJ) Int J Mol Sci 2017 Jul 27;18(8) PMID: 28749428 PMCID: PMC5578025 SCOPUS ID: 2-s2.0-85026663350 07/28/2017       2 Citations
  • Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHD. (Belle L, Zhou V, Stuhr KL, Beatka M, Siebers EM, Knight JM, Lawlor MW, Weaver C, Hashizume M, Hillard CJ, Drobyski WR) JCI Insight 2017 Jul 20;2(14) PMID: 28724796 PMCID: PMC5518565 SCOPUS ID: 2-s2.0-85033974707 07/21/2017       3 Citations
  • Circulating Endocannabinoids: From Whence Do They Come and Where are They Going? (Hillard CJ) Neuropsychopharmacology 2018 Jan;43(1):155-172 PMID: 28653665 PMCID: PMC5719092 SCOPUS ID: 2-s2.0-85036605314 06/28/2017       75 Citations
  • Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders. (Korem N, Lange R, Hillard CJ, Akirav I) Neuroscience 2017 08 15;357:285-294 PMID: 28624572 SCOPUS ID: 2-s2.0-85021388226 06/19/2017       8 Citations
  • Altered striatal endocannabinoid signaling in a transgenic mouse model of spinocerebellar ataxia type-3. (Rodríguez-Cueto C, Hernández-Gálvez M, Hillard CJ, Maciel P, Valdeolivas S, Ramos JA, Gómez-Ruiz M, Fernández-Ruiz J) PLoS One 2017;12(4):e0176521 PMID: 28448548 PMCID: PMC5407801 SCOPUS ID: 2-s2.0-85018275217 04/28/2017       2 Citations
  • Endocannabinoid and Opioid System Interactions in Exercise-Induced Hypoalgesia. (Crombie KM, Brellenthin AG, Hillard CJ, Koltyn KF) Pain Med 2018 01 01;19(1):118-123 PMID: 28387833 PMCID: PMC6454785 SCOPUS ID: 2-s2.0-85041366186 04/08/2017       25 Citations
  • Endocannabinoid and Mood Responses to Exercise in Adults with Varying Activity Levels. (Brellenthin AG, Crombie KM, Hillard CJ, Koltyn KF) Med Sci Sports Exerc 2017 08;49(8):1688-1696 PMID: 28319590 SCOPUS ID: 2-s2.0-85015696439 03/21/2017       25 Citations
  • Upregulation of fatty acid amide hydrolase in the dorsal periaqueductal gray is associated with neuropathic pain and reduced heart rate in rats. (Dean C, Hillard CJ, Seagard JL, Hopp FA, Hogan QH) Am J Physiol Regul Integr Comp Physiol 2017 04 01;312(4):R585-R596 PMID: 28148494 PMCID: PMC6668034 SCOPUS ID: 2-s2.0-85017328671 02/06/2017       1 Citation
  • Endocannabinoid Signaling and the Hypothalamic-Pituitary-Adrenal Axis. (Hillard CJ, Beatka M, Sarvaideo J) Compr Physiol 2016 12 06;7(1):1-15 PMID: 28134998 PMCID: PMC5871916 SCOPUS ID: 2-s2.0-85020983619 01/31/2017       25 Citations
  • Dysregulation of the endocannabinoid signaling system in the cerebellum and brainstem in a transgenic mouse model of spinocerebellar ataxia type-3. (Rodríguez-Cueto C, Hernández-Gálvez M, Hillard CJ, Maciel P, García-García L, Valdeolivas S, Pozo MA, Ramos JA, Gómez-Ruiz M, Fernández-Ruiz J) Neuroscience 2016 Dec 17;339:191-209 PMID: 27717809 SCOPUS ID: 2-s2.0-84992735493 11/05/2016       9 Citations
  • FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence. (Spagnolo PA, Ramchandani VA, Schwandt ML, Kwako LE, George DT, Mayo LM, Hillard CJ, Heilig M) Alcohol Clin Exp Res 2016 11;40(11):2426-2434 PMID: 27716956 PMCID: PMC5748341 SCOPUS ID: 2-s2.0-84988859573 10/21/2016       27 Citations
  • Seeing through the smoke: Human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks. (Silveira MM, Arnold JC, Laviolette SR, Hillard CJ, Celorrio M, Aymerich MS, Adams WK) Neurosci Biobehav Rev 2017 05;76(Pt B):380-395 PMID: 27639448 PMCID: PMC5350061 SCOPUS ID: 2-s2.0-84998893278 09/19/2016       12 Citations
  • Marijuana users do not have increased healthcare utilization: A National Health and Nutrition Examination Survey (NHANES) study. (Bhandari S, Hillard CJ, Venkatesan T) Eur J Intern Med 2016 Oct;34:e9-e10 PMID: 27499177 SCOPUS ID: 2-s2.0-84994172697 08/09/2016       3 Citations
  • Endocannabinoid Responses To Exercise In Low, Moderate, And High Active Individuals: 3765 Board #204 June 4, 8: 00 AM - 9: 30 AM. (Brellenthin AG, Crombie KM, Hillard CJ, Koltyn KF) Med Sci Sports Exerc 2016 May;48(5 Suppl 1):1052-3 PMID: 27362131 07/01/2016    
  • Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease. (Celorrio M, Fernández-Suárez D, Rojo-Bustamante E, Echeverry-Alzate V, Ramírez MJ, Hillard CJ, López-Moreno JA, Maldonado R, Oyarzábal J, Franco R, Aymerich MS) Brain Behav Immun 2016 Oct;57:94-105 PMID: 27318096 SCOPUS ID: 2-s2.0-84977659397 06/19/2016       24 Citations
  • Components of the cannabinoid system in the dorsal periaqueductal gray are related to resting heart rate. (Dean C, Hillard CJ, Seagard JL, Hopp FA, Hogan QH) Am J Physiol Regul Integr Comp Physiol 2016 08 01;311(2):R254-62 PMID: 27280429 PMCID: PMC4982395 SCOPUS ID: 2-s2.0-84984649626 06/10/2016       6 Citations
  • Endocannabinoid-related lipids are increased during an episode of cyclic vomiting syndrome. (Venkatesan T, Zadvornova Y, Raff H, Hillard CJ) Neurogastroenterol Motil 2016 Sep;28(9):1409-18 PMID: 27098832 PMCID: PMC5002231 SCOPUS ID: 2-s2.0-84983490957 04/22/2016       18 Citations
  • Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. (Gray JM, Wilson CD, Lee TT, Pittman QJ, Deussing JM, Hillard CJ, McEwen BS, Schulkin J, Karatsoreos IN, Patel S, Hill MN) Psychoneuroendocrinology 2016 Apr;66:151-8 PMID: 26821211 PMCID: PMC4788523 SCOPUS ID: 2-s2.0-84960901292 01/29/2016       28 Citations
  • The Endocannabinoid Signaling System in the CNS: A Primer. (Hillard CJ) Int Rev Neurobiol 2015;125:1-47 PMID: 26638763 PMCID: PMC6813823 SCOPUS ID: 2-s2.0-84949035273 12/08/2015       39 Citations
  • Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol. (Hanlon EC, Tasali E, Leproult R, Stuhr KL, Doncheck E, de Wit H, Hillard CJ, Van Cauter E) Sleep 2016 Mar 01;39(3):653-64 PMID: 26612385 PMCID: PMC4763355 SCOPUS ID: 2-s2.0-84960359506 11/28/2015       44 Citations
  • The endocannabinoid system in guarding against fear, anxiety and stress. (Lutz B, Marsicano G, Maldonado R, Hillard CJ) Nat Rev Neurosci 2015 12;16(12):705-18 PMID: 26585799 PMCID: PMC5871913 SCOPUS ID: 2-s2.0-84947923864 11/21/2015       155 Citations
  • CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats. (McReynolds JR, Doncheck EM, Vranjkovic O, Ganzman GS, Baker DA, Hillard CJ, Mantsch JR) Psychopharmacology (Berl) 2016 Jan;233(1):99-109 PMID: 26455361 PMCID: PMC4703460 SCOPUS ID: 2-s2.0-84953275278 10/13/2015       17 Citations
  • Endocannabinoids and the Endocrine System in Health and Disease. (Hillard CJ) Handb Exp Pharmacol 2015;231:317-39 PMID: 26408166 PMCID: PMC6813821 SCOPUS ID: 2-s2.0-84955712415 09/27/2015    
  • Endocannabinoid regulation of amyloid-induced neuroinflammation. (Vázquez C, Tolón RM, Grande MT, Caraza M, Moreno M, Koester EC, Villaescusa B, Ruiz-Valdepeñas L, Fernández-Sánchez FJ, Cravatt BF, Hillard CJ, Romero J) Neurobiol Aging 2015 Nov;36(11):3008-3019 PMID: 26362942 SCOPUS ID: 2-s2.0-84947041175 09/13/2015       9 Citations
  • Disruption of peri-adolescent endocannabinoid signaling modulates adult neuroendocrine and behavioral responses to stress in male rats. (Lee TT, Hill MN, Hillard CJ, Gorzalka BB) Neuropharmacology 2015 Dec;99:89-97 PMID: 26192544 SCOPUS ID: 2-s2.0-84938261822 07/21/2015       13 Citations
  • Circulating endocannabinoids during hematopoietic stem cell transplantation: A pilot study. (Knight JM, Szabo A, Zhao S, Lyness JM, Sahler OJ, Liesveld JL, Sander T, Rizzo JD, Hillard CJ, Moynihan JA) Neurobiol Stress 2015;2:44-50 PMID: 26114153 PMCID: PMC4476410 06/27/2015    
  • An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction. (Hutch CR, Hillard CJ, Jia C, Hegg CC) Neuroscience 2015 Aug 06;300:539-53 PMID: 26037800 PMCID: PMC4485596 SCOPUS ID: 2-s2.0-84930959429 06/04/2015       6 Citations
  • Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies. (Vázquez C, Tolón RM, Pazos MR, Moreno M, Koester EC, Cravatt BF, Hillard CJ, Romero J) Neurobiol Dis 2015 Jul;79:41-50 PMID: 25917763 SCOPUS ID: 2-s2.0-84928599358 04/29/2015       22 Citations
  • A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome. (Bowles NP, Karatsoreos IN, Li X, Vemuri VK, Wood JA, Li Z, Tamashiro KL, Schwartz GJ, Makriyannis AM, Kunos G, Hillard CJ, McEwen BS, Hill MN) Proc Natl Acad Sci U S A 2015 Jan 06;112(1):285-90 PMID: 25535367 PMCID: PMC4291642 SCOPUS ID: 2-s2.0-84920450557 12/24/2014       55 Citations
  • Attenuation of cystitis and pain sensation in mice lacking fatty acid amide hydrolase. (Wang ZY, Wang P, Hillard CJ, Bjorling DE) J Mol Neurosci 2015 Apr;55(4):968-76 PMID: 25374388 PMCID: PMC4355044 SCOPUS ID: 2-s2.0-84925538196 11/07/2014       5 Citations
  • Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol. (Hanlon EC, Tasali E, Leproult R, Stuhr KL, Doncheck E, de Wit H, Hillard CJ, Van Cauter E) J Clin Endocrinol Metab 2015 Jan;100(1):220-6 PMID: 25368979 PMCID: PMC5399498 SCOPUS ID: 2-s2.0-84920614665 11/05/2014       39 Citations
  • Mechanisms of exercise-induced hypoalgesia. (Koltyn KF, Brellenthin AG, Cook DB, Sehgal N, Hillard C) J Pain 2014 Dec;15(12):1294-1304 PMID: 25261342 PMCID: PMC4302052 SCOPUS ID: 2-s2.0-84916216876 09/28/2014       113 Citations
  • Cannabinoids, endocannabinoids and stress (Hillard CJ, Liu Qs, Liu XQ, Pan B, Roberts CJ, Shi L) Cannabinoids August 11, 2014:139-174 SCOPUS ID: 2-s2.0-84947595350 08/11/2014    
  • Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. (Fernández-Suárez D, Celorrio M, Riezu-Boj JI, Ugarte A, Pacheco R, González H, Oyarzabal J, Hillard CJ, Franco R, Aymerich MS) Neurobiol Aging 2014 Nov;35(11):2603-2616 PMID: 24973119 SCOPUS ID: 2-s2.0-84922880383 06/29/2014       45 Citations
  • Stress regulates endocannabinoid-CB1 receptor signaling. (Hillard CJ) Semin Immunol 2014 Oct;26(5):380-8 PMID: 24882055 PMCID: PMC4247817 SCOPUS ID: 2-s2.0-84922741113 06/03/2014       45 Citations
  • Differential muscle hypertrophy is associated with satellite cell numbers and Akt pathway activation following activin type IIB receptor inhibition in Mtm1 p.R69C mice. (Lawlor MW, Viola MG, Meng H, Edelstein RV, Liu F, Yan K, Luna EJ, Lerch-Gaggl A, Hoffmann RG, Pierson CR, Buj-Bello A, Lachey JL, Pearsall S, Yang L, Hillard CJ, Beggs AH) Am J Pathol 2014 Jun;184(6):1831-42 PMID: 24726641 PMCID: PMC4044712 SCOPUS ID: 2-s2.0-84901020192 04/15/2014       17 Citations
  • Sterol carrier protein-2: binding protein for endocannabinoids. (Liedhegner ES, Vogt CD, Sem DS, Cunningham CW, Hillard CJ) Mol Neurobiol 2014 Aug;50(1):149-58 PMID: 24510313 PMCID: PMC4450258 SCOPUS ID: 2-s2.0-84911004168 02/11/2014       18 Citations
  • Endocannabinoid signaling in hypothalamic-pituitary-adrenocortical axis recovery following stress: effects of indirect agonists and comparison of male and female mice. (Roberts CJ, Stuhr KL, Hutz MJ, Raff H, Hillard CJ) Pharmacol Biochem Behav 2014 Feb;117:17-24 PMID: 24316201 PMCID: PMC3929302 SCOPUS ID: 2-s2.0-84890264813 12/10/2013       30 Citations
  • Endocannabinoid signaling in the etiology and treatment of major depressive illness. (Hillard CJ, Liu QS) Curr Pharm Des 2014;20(23):3795-811 PMID: 24180398 PMCID: PMC4002665 SCOPUS ID: 2-s2.0-84916885839 11/05/2013       34 Citations
  • Endocannabinoids, monoamines and stress (Hillard CJ) Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders 1 November 2013:173-212 SCOPUS ID: 2-s2.0-84929577473 11/01/2013    
  • Brain region-specific changes in N-acylethanolamine contents with time of day. (Liedhegner ES, Sasman A, Hillard CJ) J Neurochem 2014 Feb;128(4):491-506 PMID: 24138639 PMCID: PMC3946166 SCOPUS ID: 2-s2.0-84893858551 10/22/2013       12 Citations
  • Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks. (Hill MN, Bierer LM, Makotkine I, Golier JA, Galea S, McEwen BS, Hillard CJ, Yehuda R) Psychoneuroendocrinology 2013 Dec;38(12):2952-61 PMID: 24035186 PMCID: PMC3870889 SCOPUS ID: 2-s2.0-84888299927 09/17/2013       110 Citations
  • Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors. (Pazos MR, Mohammed N, Lafuente H, Santos M, Martínez-Pinilla E, Moreno E, Valdizan E, Romero J, Pazos A, Franco R, Hillard CJ, Alvarez FJ, Martínez-Orgado J) Neuropharmacology 2013 Aug;71:282-91 PMID: 23587650 SCOPUS ID: 2-s2.0-84878128163 04/17/2013       101 Citations
  • Upregulation of CB₁ receptor binding in the ventromedial prefrontal cortex promotes proactive stress-coping strategies following chronic stress exposure. (McLaughlin RJ, Hill MN, Dang SS, Wainwright SR, Galea LA, Hillard CJ, Gorzalka BB) Behav Brain Res 2013 Jan 15;237:333-7 PMID: 23047058 PMCID: PMC3501995 SCOPUS ID: 2-s2.0-84867615880 10/11/2012       33 Citations
  • Temporal changes in N-acylethanolamine content and metabolism throughout the peri-adolescent period. (Lee TT, Hill MN, Hillard CJ, Gorzalka BB) Synapse 2013 Jan;67(1):4-10 PMID: 22987804 PMCID: PMC3510355 SCOPUS ID: 2-s2.0-84870319187 09/19/2012       43 Citations
  • Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure. (Hill MN, Kumar SA, Filipski SB, Iverson M, Stuhr KL, Keith JM, Cravatt BF, Hillard CJ, Chattarji S, McEwen BS) Mol Psychiatry 2013 Oct;18(10):1125-35 PMID: 22776900 PMCID: PMC4148304 SCOPUS ID: 2-s2.0-84884674660 07/11/2012       117 Citations
  • Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans. (Dlugos A, Childs E, Stuhr KL, Hillard CJ, de Wit H) Neuropsychopharmacology 2012 Oct;37(11):2416-27 PMID: 22763622 PMCID: PMC3442338 SCOPUS ID: 2-s2.0-84866378334 07/06/2012       98 Citations
  • Circulating endocannabinoid concentrations and sexual arousal in women. (Klein C, Hill MN, Chang SC, Hillard CJ, Gorzalka BB) J Sex Med 2012 Jun;9(6):1588-601 PMID: 22462722 PMCID: PMC3856894 04/03/2012    
  • Serum contents of endocannabinoids are correlated with blood pressure in depressed women. (Ho WS, Hill MN, Miller GE, Gorzalka BB, Hillard CJ) Lipids Health Dis 2012 Feb 28;11:32 PMID: 22373123 PMCID: PMC3334711 SCOPUS ID: 2-s2.0-84857410633 03/01/2012       25 Citations
  • Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. (McLaughlin RJ, Hill MN, Bambico FR, Stuhr KL, Gobbi G, Hillard CJ, Gorzalka BB) Eur Neuropsychopharmacol 2012 Sep;22(9):664-71 PMID: 22325231 PMCID: PMC3366159 SCOPUS ID: 2-s2.0-84865033949 02/14/2012       64 Citations
  • Swim stress differentially affects limbic contents of 2-arachidonoylglycerol and 2-oleoylglycerol. (Roberts CJ, Stuhr KL, Hillard CJ) Neuroscience 2012 Mar 01;204:74-82 PMID: 22192839 PMCID: PMC3288304 SCOPUS ID: 2-s2.0-84857125720 12/24/2011       10 Citations
  • Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence. (Hillard CJ, Weinlander KM, Stuhr KL) Neuroscience 2012 Mar 01;204:207-29 PMID: 22123166 PMCID: PMC3288440 SCOPUS ID: 2-s2.0-84857125719 11/30/2011       97 Citations
  • Chronic, noninvasive glucocorticoid administration suppresses limbic endocannabinoid signaling in mice. (Bowles NP, Hill MN, Bhagat SM, Karatsoreos IN, Hillard CJ, McEwen BS) Neuroscience 2012 Mar 01;204:83-9 PMID: 21939741 PMCID: PMC3697830 SCOPUS ID: 2-s2.0-84857128136 09/24/2011       40 Citations
  • Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation. (Wang M, Hill MN, Zhang L, Gorzalka BB, Hillard CJ, Alger BE) J Psychopharmacol 2012 Jan;26(1):56-70 PMID: 21890595 PMCID: PMC3373303 SCOPUS ID: 2-s2.0-84863011182 09/06/2011       82 Citations
  • Cannabinoid receptor involvement in stress-induced cocaine reinstatement: potential interaction with noradrenergic pathways. (Vaughn LK, Mantsch JR, Vranjkovic O, Stroh G, Lacourt M, Kreutter M, Hillard CJ) Neuroscience 2012 Mar 01;204:117-24 PMID: 21871539 PMCID: PMC3422566 SCOPUS ID: 2-s2.0-84857125721 08/30/2011       29 Citations
  • Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. (Hill MN, McLaughlin RJ, Pan B, Fitzgerald ML, Roberts CJ, Lee TT, Karatsoreos IN, Mackie K, Viau V, Pickel VM, McEwen BS, Liu QS, Gorzalka BB, Hillard CJ) J Neurosci 2011 Jul 20;31(29):10506-15 PMID: 21775596 PMCID: PMC3179266 SCOPUS ID: 2-s2.0-79960676744 07/22/2011       197 Citations
  • Alterations in corticolimbic dendritic morphology and emotional behavior in cannabinoid CB1 receptor-deficient mice parallel the effects of chronic stress. (Hill MN, Hillard CJ, McEwen BS) Cereb Cortex 2011 Sep;21(9):2056-64 PMID: 21263035 PMCID: PMC3155602 SCOPUS ID: 2-s2.0-79959969118 01/26/2011       77 Citations
  • Natural and synthetic corticosteroids inhibit uptake 2-mediated transport in CNS neurons. (Hill JE, Makky K, Shrestha L, Hillard CJ, Gasser PJ) Physiol Behav 2011 Aug 03;104(2):306-11 PMID: 21081135 SCOPUS ID: 2-s2.0-79958850049 11/18/2010       16 Citations
  • Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior. (Krebs-Kraft DL, Hill MN, Hillard CJ, McCarthy MM) Proc Natl Acad Sci U S A 2010 Nov 23;107(47):20535-40 PMID: 21059913 PMCID: PMC2996668 11/10/2010       51 Citations
  • Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. (Ghosh A, Chandran K, Kalivendi SV, Joseph J, Antholine WE, Hillard CJ, Kanthasamy A, Kanthasamy A, Kalyanaraman B) Free Radic Biol Med 2010 Dec 01;49(11):1674-84 PMID: 20828611 PMCID: PMC4020411 SCOPUS ID: 2-s2.0-78049357951 09/11/2010       104 Citations
  • Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation. (Merriam FV, Wang ZY, Hillard CJ, Stuhr KL, Bjorling DE) BJU Int 2011 Oct;108(7):1145-9 PMID: 20804480 PMCID: PMC3505723 SCOPUS ID: 2-s2.0-80052797640 09/02/2010       27 Citations
  • Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling. (Evanson NK, Tasker JG, Hill MN, Hillard CJ, Herman JP) Endocrinology 2010 Oct;151(10):4811-9 PMID: 20702575 PMCID: PMC2946139 SCOPUS ID: 2-s2.0-77957276332 08/13/2010       193 Citations
  • Deficiency in endocannabinoid signaling in the nucleus accumbens induced by chronic unpredictable stress. (Wang W, Sun D, Pan B, Roberts CJ, Sun X, Hillard CJ, Liu QS) Neuropsychopharmacology 2010 Oct;35(11):2249-61 PMID: 20664582 PMCID: PMC3055309 SCOPUS ID: 2-s2.0-78651314453 07/29/2010       68 Citations
  • Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex. (Ho WS, Patel S, Thompson JR, Roberts CJ, Stuhr KL, Hillard CJ) Br J Pharmacol 2010 Jun;160(3):736-46 PMID: 20590576 PMCID: PMC2931572 SCOPUS ID: 2-s2.0-77952633980 07/02/2010       8 Citations
  • Endocannabinoid signalling: has it got rhythm? (Vaughn LK, Denning G, Stuhr KL, de Wit H, Hill MN, Hillard CJ) Br J Pharmacol 2010 Jun;160(3):530-43 PMID: 20590563 PMCID: PMC2931554 SCOPUS ID: 2-s2.0-77952622170 07/02/2010       71 Citations
  • Retrograde release of endocannabinoids inhibits presynaptic GABA release to second-order baroreceptive neurons in NTS. (Chen CY, Bonham AC, Dean C, Hopp FA, Hillard CJ, Seagard JL) Auton Neurosci 2010 Dec 08;158(1-2):44-50 PMID: 20580326 PMCID: PMC2976795 SCOPUS ID: 2-s2.0-78149408566 06/29/2010       14 Citations
  • Endogenous cannabinoid signaling is essential for stress adaptation. (Hill MN, McLaughlin RJ, Bingham B, Shrestha L, Lee TT, Gray JM, Hillard CJ, Gorzalka BB, Viau V) Proc Natl Acad Sci U S A 2010 May 18;107(20):9406-11 PMID: 20439721 PMCID: PMC2889099 SCOPUS ID: 2-s2.0-77952717194 05/05/2010       213 Citations
  • Rapid elevations in limbic endocannabinoid content by glucocorticoid hormones in vivo. (Hill MN, Karatsoreos IN, Hillard CJ, McEwen BS) Psychoneuroendocrinology 2010 Oct;35(9):1333-8 PMID: 20399021 PMCID: PMC2914801 SCOPUS ID: 2-s2.0-77956618349 04/20/2010       105 Citations
  • Estrogenic regulation of limbic cannabinoid receptor binding. (Riebe CJ, Hill MN, Lee TT, Hillard CJ, Gorzalka BB) Psychoneuroendocrinology 2010 Sep;35(8):1265-9 PMID: 20207489 PMCID: PMC2933663 SCOPUS ID: 2-s2.0-77955578727 03/09/2010       65 Citations
  • Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent. (Zhang Y, Sonnenberg GE, Baye TM, Littrell J, Gunnell J, DeLaForest A, MacKinney E, Hillard CJ, Kissebah AH, Olivier M, Wilke RA) Pharmacogenomics 2009 Dec;10(12):1929-39 PMID: 19958092 PMCID: PMC3003434 SCOPUS ID: 2-s2.0-73649131984 12/05/2009       16 Citations
  • Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease. (Kalivendi SV, Yedlapudi D, Hillard CJ, Kalyanaraman B) Free Radic Biol Med 2010 Feb 01;48(3):377-83 PMID: 19857570 PMCID: PMC4485429 SCOPUS ID: 2-s2.0-73449099224 10/28/2009       31 Citations
  • The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants. (Hill MN, Hillard CJ, Bambico FR, Patel S, Gorzalka BB, Gobbi G) Trends Pharmacol Sci 2009 Sep;30(9):484-93 PMID: 19732971 SCOPUS ID: 2-s2.0-69549116206 09/08/2009       110 Citations
  • Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis. (Hill MN, McLaughlin RJ, Morrish AC, Viau V, Floresco SB, Hillard CJ, Gorzalka BB) Neuropsychopharmacology 2009 Dec;34(13):2733-45 PMID: 19710634 PMCID: PMC3197779 SCOPUS ID: 2-s2.0-70449529389 08/28/2009       181 Citations
  • Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. (Pan B, Wang W, Long JZ, Sun D, Hillard CJ, Cravatt BF, Liu QS) J Pharmacol Exp Ther 2009 Nov;331(2):591-7 PMID: 19666749 PMCID: PMC2775254 SCOPUS ID: 2-s2.0-70350455918 08/12/2009       116 Citations
  • Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus. (Hill MN, Titterness AK, Morrish AC, Carrier EJ, Lee TT, Gil-Mohapel J, Gorzalka BB, Hillard CJ, Christie BR) Hippocampus 2010 Apr;20(4):513-23 PMID: 19489006 PMCID: PMC2847038 SCOPUS ID: 2-s2.0-77950113882 06/03/2009       78 Citations
  • Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats. (Brozoski DT, Dean C, Hopp FA, Hillard CJ, Seagard JL) Auton Neurosci 2009 Oct 05;150(1-2):82-93 PMID: 19464961 PMCID: PMC3815570 SCOPUS ID: 2-s2.0-69349092082 05/26/2009       23 Citations
  • Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. (Hill MN, Miller GE, Carrier EJ, Gorzalka BB, Hillard CJ) Psychoneuroendocrinology 2009 Sep;34(8):1257-62 PMID: 19394765 PMCID: PMC2716432 SCOPUS ID: 2-s2.0-67650617724 04/28/2009       152 Citations
  • Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents (Journal of Neural Transmission (2008) 115, (1673-1679) DOI: 10.1007/s00702-008-0131-7) (Hill MN, Ho WSV, Hillard CJ, Gorzalka BB) Journal of Neural Transmission February 2009;116(2):141 SCOPUS ID: 2-s2.0-59849096250 02/01/2009    
  • Role of endocannabinoid signaling in anxiety and depression. (Patel S, Hillard CJ) Curr Top Behav Neurosci 2009;1:347-71 PMID: 21104391 PMCID: PMC3808114 SCOPUS ID: 2-s2.0-79952118933 01/01/2009       23 Citations
  • D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling. (Pan B, Hillard CJ, Liu QS) J Neurosci 2008 Dec 24;28(52):14018-30 PMID: 19109485 PMCID: PMC2656602 SCOPUS ID: 2-s2.0-58149373942 12/26/2008       90 Citations
  • Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. (Hill MN et al.) J Neural Transm 2009 Feb;116(2):141 PMID: 19093190 12/19/2008    
  • Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index. (Baye TM, Zhang Y, Smith E, Hillard CJ, Gunnell J, Myklebust J, James R, Kissebah AH, Olivier M, Wilke RA) Pharmacogenomics 2008 Nov;9(11):1647-56 PMID: 19018721 PMCID: PMC2784739 SCOPUS ID: 2-s2.0-61549101858 11/21/2008       35 Citations
  • Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. (Hill MN, Ho WS, Hillard CJ, Gorzalka BB) J Neural Transm (Vienna) 2008 Dec;115(12):1673-9 PMID: 18974922 PMCID: PMC2992975 SCOPUS ID: 2-s2.0-57049099128 11/01/2008       47 Citations
  • Role of cannabinoids and endocannabinoids in cerebral ischemia. (Hillard CJ) Curr Pharm Des 2008;14(23):2347-61 PMID: 18781985 PMCID: PMC2581413 SCOPUS ID: 2-s2.0-52949119940 09/11/2008       90 Citations
  • Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. (Hill MN, Carrier EJ, McLaughlin RJ, Morrish AC, Meier SE, Hillard CJ, Gorzalka BB) J Neurochem 2008 Sep;106(6):2322-36 PMID: 18643796 PMCID: PMC2606621 SCOPUS ID: 2-s2.0-50849142856 07/23/2008       151 Citations
  • Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor. (Liou GI, Auchampach JA, Hillard CJ, Zhu G, Yousufzai B, Mian S, Khan S, Khalifa Y) Invest Ophthalmol Vis Sci 2008 Dec;49(12):5526-31 PMID: 18641283 PMCID: PMC2588644 SCOPUS ID: 2-s2.0-58149269741 07/22/2008       78 Citations
  • Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation. (Patel S, Hillard CJ) Eur J Neurosci 2008 Jun;27(11):2821-9 PMID: 18588527 PMCID: PMC2593941 SCOPUS ID: 2-s2.0-45149111341 07/01/2008       112 Citations
  • Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders. (Gorzalka BB, Hill MN, Hillard CJ) Neurosci Biobehav Rev 2008 Aug;32(6):1152-60 PMID: 18433869 SCOPUS ID: 2-s2.0-45849113264 04/25/2008       150 Citations
  • Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report. (Hill MN, Miller GE, Ho WS, Gorzalka BB, Hillard CJ) Pharmacopsychiatry 2008 Mar;41(2):48-53 PMID: 18311684 PMCID: PMC3422568 SCOPUS ID: 2-s2.0-41149130214 03/04/2008       156 Citations
  • Endocannabinoid signaling mediates cocaine-induced inhibitory synaptic plasticity in midbrain dopamine neurons. (Pan B, Hillard CJ, Liu QS) J Neurosci 2008 Feb 06;28(6):1385-97 PMID: 18256258 PMCID: PMC6671588 SCOPUS ID: 2-s2.0-38949143318 02/08/2008       105 Citations
  • Characterization of epoxyeicosatrienoic acid binding site in U937 membranes using a novel radiolabeled agonist, 20-125i-14,15-epoxyeicosa-8(Z)-enoic acid. (Yang W, Tuniki VR, Anjaiah S, Falck JR, Hillard CJ, Campbell WB) J Pharmacol Exp Ther 2008 Mar;324(3):1019-27 PMID: 18171909 SCOPUS ID: 2-s2.0-40849139451 01/04/2008       67 Citations
  • Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome. (Núñez E, Benito C, Tolón RM, Hillard CJ, Griffin WS, Romero J) Neuroscience 2008 Jan 02;151(1):104-10 PMID: 18068305 SCOPUS ID: 2-s2.0-37849049077 12/11/2007       61 Citations
  • Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. (Hill MN, Carrier EJ, Ho WS, Shi L, Patel S, Gorzalka BB, Hillard CJ) Hippocampus 2008;18(2):221-6 PMID: 18058925 SCOPUS ID: 2-s2.0-39849106394 12/07/2007       72 Citations
  • Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future research. (Katz R, Hamilton JA, Pownall HJ, Deckelbaum RJ, Hillard CJ, Leboeuf RC, Watkins PA) J Mol Neurosci 2007 Sep;33(1):146-50 PMID: 17901559 SCOPUS ID: 2-s2.0-35348927453 09/29/2007       9 Citations
  • Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase. (Hillard CJ, Shi L, Tuniki VR, Falck JR, Campbell WB) J Mol Neurosci 2007 Sep;33(1):18-24 PMID: 17901541 PMCID: PMC2248273 SCOPUS ID: 2-s2.0-35348851360 09/29/2007       26 Citations
  • Brain uptake and utilization of fatty acids, lipids and lipoproteins: application to neurological disorders. (Hamilton JA, Hillard CJ, Spector AA, Watkins PA) J Mol Neurosci 2007 Sep;33(1):2-11 PMID: 17901539 SCOPUS ID: 2-s2.0-35348879692 09/29/2007       40 Citations
  • Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. (Hillard CJ, Ho WS, Thompson J, Gauthier KM, Wheelock CE, Huang H, Hammock BD) Br J Pharmacol 2007 Nov;152(5):691-8 PMID: 17891162 PMCID: PMC2190024 SCOPUS ID: 2-s2.0-35649005473 09/25/2007       24 Citations
  • Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice. (Rademacher DJ, Meier SE, Shi L, Ho WS, Jarrahian A, Hillard CJ) Neuropharmacology 2008 Jan;54(1):108-16 PMID: 17675104 SCOPUS ID: 2-s2.0-37349065102 08/07/2007       158 Citations
  • Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activity. (Hill MN, Barr AM, Ho WS, Carrier EJ, Gorzalka BB, Hillard CJ) J Neurochem 2007 Oct;103(1):47-56 PMID: 17561935 SCOPUS ID: 2-s2.0-34548648818 06/15/2007       33 Citations
  • Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. (Maresz K, Pryce G, Ponomarev ED, Marsicano G, Croxford JL, Shriver LP, Ledent C, Cheng X, Carrier EJ, Mann MK, Giovannoni G, Pertwee RG, Yamamura T, Buckley NE, Hillard CJ, Lutz B, Baker D, Dittel BN) Nat Med 2007 Apr;13(4):492-7 PMID: 17401376 SCOPUS ID: 2-s2.0-34147165471 04/03/2007       265 Citations
  • Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. (Benito C, Romero JP, Tolón RM, Clemente D, Docagne F, Hillard CJ, Guaza C, Romero J) J Neurosci 2007 Feb 28;27(9):2396-402 PMID: 17329437 PMCID: PMC6673484 SCOPUS ID: 2-s2.0-33847420442 03/03/2007       188 Citations
  • Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward. (Rademacher DJ, Hillard CJ) Prog Neuropsychopharmacol Biol Psychiatry 2007 Apr 13;31(3):633-41 PMID: 17258369 PMCID: PMC1876712 SCOPUS ID: 2-s2.0-33947536045 01/30/2007       62 Citations
  • Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axis. (Hill MN, Ho WS, Sinopoli KJ, Viau V, Hillard CJ, Gorzalka BB) Neuropsychopharmacology 2006 Dec;31(12):2591-9 PMID: 16710317 SCOPUS ID: 2-s2.0-33748712399 05/20/2006       93 Citations
  • Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. (Carrier EJ, Auchampach JA, Hillard CJ) Proc Natl Acad Sci U S A 2006 May 16;103(20):7895-900 PMID: 16672367 PMCID: PMC1472541 SCOPUS ID: 2-s2.0-33646734889 05/05/2006       261 Citations
  • Modulators of endocannabinoid enzymic hydrolysis and membrane transport. (Ho WS, Hillard CJ) Handb Exp Pharmacol 2005(168):187-207 PMID: 16596775 SCOPUS ID: 2-s2.0-27644514002 04/07/2006       29 Citations
  • Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling. (Patel S, Hillard CJ) J Pharmacol Exp Ther 2006 Jul;318(1):304-11 PMID: 16569753 SCOPUS ID: 2-s2.0-33745261630 03/30/2006       284 Citations
  • Fetomaternal cross talk in the placental vascular bed: control of coagulation by trophoblast cells. (Sood R, Kalloway S, Mast AE, Hillard CJ, Weiler H) Blood 2006 Apr 15;107(8):3173-80 PMID: 16380449 PMCID: PMC1895751 SCOPUS ID: 2-s2.0-33645746632 12/29/2005       68 Citations
  • Endocannabinoids in neuroimmunology and stress. (Carrier EJ, Patel S, Hillard CJ) Curr Drug Targets CNS Neurol Disord 2005 Dec;4(6):657-65 PMID: 16375683 SCOPUS ID: 2-s2.0-28944444774 12/27/2005       49 Citations
  • Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdala. (Hill MN, Ho WS, Meier SE, Gorzalka BB, Hillard CJ) Eur J Pharmacol 2005 Dec 28;528(1-3):99-102 PMID: 16324692 SCOPUS ID: 2-s2.0-28844445664 12/06/2005       30 Citations
  • Reticulocyte 15-lipoxygenase-I is important in acetylcholine-induced endothelium-dependent vasorelaxation in rabbit aorta. (Tang X, Holmes BB, Nithipatikom K, Hillard CJ, Kuhn H, Campbell WB) Arterioscler Thromb Vasc Biol 2006 Jan;26(1):78-84 PMID: 16239596 SCOPUS ID: 2-s2.0-33644824103 10/22/2005       29 Citations
  • Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide, and proteasome activation. (Shang T, Kotamraju S, Zhao H, Kalivendi SV, Hillard CJ, Kalyanaraman B) Free Radic Biol Med 2005 Oct 15;39(8):1059-74 PMID: 16198233 SCOPUS ID: 2-s2.0-25144483746 10/04/2005       27 Citations
  • Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli. (Maresz K, Carrier EJ, Ponomarev ED, Hillard CJ, Dittel BN) J Neurochem 2005 Oct;95(2):437-45 PMID: 16086683 SCOPUS ID: 2-s2.0-26844448746 08/10/2005       302 Citations
  • Death-associated protein kinase as a sensor of mitochondrial membrane potential: role of lysosome in mitochondrial toxin-induced cell death. (Shang T, Joseph J, Hillard CJ, Kalyanaraman B) J Biol Chem 2005 Oct 14;280(41):34644-53 PMID: 16085644 SCOPUS ID: 2-s2.0-27144458235 08/09/2005       33 Citations
  • Lipids and drugs of abuse. (Hillard CJ) Life Sci 2005 Aug 19;77(14):1531-42 PMID: 15946699 SCOPUS ID: 2-s2.0-23044494981 06/11/2005       16 Citations
  • Accumulation of anandamide: evidence for cellular diversity. (Hillard CJ, Jarrahian A) Neuropharmacology 2005 Jun;48(8):1072-8 PMID: 15910883 SCOPUS ID: 2-s2.0-19444375706 05/25/2005       34 Citations
  • Effects of endocannabinoids on discharge of baroreceptive NTS neurons. (Seagard JL, Hopp FA, Hillard CJ, Dean C) Neurosci Lett 2005 Jun 24;381(3):334-9 PMID: 15896495 SCOPUS ID: 2-s2.0-19344369593 05/18/2005       22 Citations
  • Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling. (Patel S, Roelke CT, Rademacher DJ, Hillard CJ) Eur J Neurosci 2005 Feb;21(4):1057-69 PMID: 15787710 SCOPUS ID: 2-s2.0-16244398653 03/25/2005       210 Citations
  • A glial endogenous cannabinoid system is upregulated in the brains of macaques with simian immunodeficiency virus-induced encephalitis. (Benito C, Kim WK, Chavarría I, Hillard CJ, Mackie K, Tolón RM, Williams K, Romero J) J Neurosci 2005 Mar 09;25(10):2530-6 PMID: 15758162 PMCID: PMC6725174 SCOPUS ID: 2-s2.0-14944367009 03/11/2005       108 Citations
  • U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance. (Rademacher DJ, Patel S, Ho WS, Savoie AM, Rusch NJ, Gauthier KM, Hillard CJ) Am J Physiol Heart Circ Physiol 2005 Jun;288(6):H2694-701 PMID: 15695564 SCOPUS ID: 2-s2.0-19344367770 02/08/2005       22 Citations
  • Characterization of phospholipase activity of the Pseudomonas aeruginosa type III cytotoxin, ExoU. (Sato H, Feix JB, Hillard CJ, Frank DW) J Bacteriol 2005 Feb;187(3):1192-5 PMID: 15659695 PMCID: PMC545705 SCOPUS ID: 2-s2.0-13244295376 01/22/2005       49 Citations
  • 2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion. (Nithipatikom K, Endsley MP, Isbell MA, Falck JR, Iwamoto Y, Hillard CJ, Campbell WB) Cancer Res 2004 Dec 15;64(24):8826-30 PMID: 15604240 SCOPUS ID: 2-s2.0-10844265493 12/18/2004       100 Citations
  • The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. (Patel S, Carrier EJ, Ho WS, Rademacher DJ, Cunningham S, Reddy DS, Falck JR, Cravatt BF, Hillard CJ) J Lipid Res 2005 Feb;46(2):342-9 PMID: 15576840 SCOPUS ID: 2-s2.0-13944272187 12/04/2004       106 Citations
  • Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia. (Muthian S, Rademacher DJ, Roelke CT, Gross GJ, Hillard CJ) Neuroscience 2004;129(3):743-50 PMID: 15541895 SCOPUS ID: 2-s2.0-8444250235 11/16/2004       115 Citations
  • Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. (Gauthier KM, Baewer DV, Hittner S, Hillard CJ, Nithipatikom K, Reddy DS, Falck JR, Campbell WB) Am J Physiol Heart Circ Physiol 2005 Mar;288(3):H1344-51 PMID: 15528233 SCOPUS ID: 2-s2.0-13944262157 11/06/2004       60 Citations
  • Waterborne lead exposure affects brain endocannabinoid content in male but not female fathead minnows (Pimephales promelas). (Rademacher DJ, Weber DN, Hillard CJ) Neurotoxicology 2005 Jan;26(1):9-15 PMID: 15527869 SCOPUS ID: 2-s2.0-7444252224 11/06/2004       13 Citations
  • Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress. (Hill MN, Patel S, Carrier EJ, Rademacher DJ, Ormerod BK, Hillard CJ, Gorzalka BB) Neuropsychopharmacology 2005 Mar;30(3):508-15 PMID: 15525997 SCOPUS ID: 2-s2.0-13944280321 11/05/2004       252 Citations
  • Spatial correlations of laminar BOLD and CBV responses to rat whisker stimulation with neuronal activity localized by Fos expression. (Lu H, Patel S, Luo F, Li SJ, Hillard CJ, Ward BD, Hyde JS) Magn Reson Med 2004 Nov;52(5):1060-8 PMID: 15508149 SCOPUS ID: 2-s2.0-7544245944 10/28/2004       89 Citations
  • Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis. (Patel S, Roelke CT, Rademacher DJ, Cullinan WE, Hillard CJ) Endocrinology 2004 Dec;145(12):5431-8 PMID: 15331569 SCOPUS ID: 2-s2.0-9444277292 08/28/2004       347 Citations
  • Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala. (Patel S, Cravatt BF, Hillard CJ) Neuropsychopharmacology 2005 Mar;30(3):497-507 PMID: 15280883 SCOPUS ID: 2-s2.0-13944278876 07/29/2004       113 Citations
  • Dendritically released transmitters cooperate via autocrine and retrograde actions to inhibit afferent excitation in rat brain. (Hirasawa M, Schwab Y, Natah S, Hillard CJ, Mackie K, Sharkey KA, Pittman QJ) J Physiol 2004 Sep 01;559(Pt 2):611-24 PMID: 15254151 PMCID: PMC1665137 SCOPUS ID: 2-s2.0-4644280012 07/16/2004       108 Citations
  • Chronic administration of nitric oxide reduces angiotensin II receptor type 1 expression and aldosterone synthesis in zona glomerulosa cells. (Nithipatikom K, Holmes BB, McCoy MJ, Hillard CJ, Campbell WB) Am J Physiol Endocrinol Metab 2004 Nov;287(5):E820-7 PMID: 15198935 SCOPUS ID: 2-s2.0-6044274619 06/17/2004       11 Citations
  • Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. (Carrier EJ, Kearn CS, Barkmeier AJ, Breese NM, Yang W, Nithipatikom K, Pfister SL, Campbell WB, Hillard CJ) Mol Pharmacol 2004 Apr;65(4):999-1007 PMID: 15044630 SCOPUS ID: 2-s2.0-1842428537 03/27/2004       261 Citations
  • Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line. (Rademacher DJ, Kearn CS, Carrier EJ, Patel S, Delgado MA, Barkmeier A, Klick DE, Breese NM, Pfister SL, Nithipatikom K, Campbell WB, Hillard CJ) J Neuroimmunol 2004 Apr;149(1-2):130-41 PMID: 15020073 SCOPUS ID: 2-s2.0-12144287853 03/17/2004       7 Citations
  • 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. (Shang T, Kotamraju S, Kalivendi SV, Hillard CJ, Kalyanaraman B) J Biol Chem 2004 Apr 30;279(18):19099-112 PMID: 14752097 SCOPUS ID: 2-s2.0-2442504779 01/31/2004       51 Citations
  • Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide. (Kalivendi SV, Cunningham S, Kotamraju S, Joseph J, Hillard CJ, Kalyanaraman B) J Biol Chem 2004 Apr 09;279(15):15240-7 PMID: 14742448 SCOPUS ID: 2-s2.0-2442494278 01/27/2004       107 Citations
  • Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study. (Ruiz-Llorente L, Ortega-Gutiérrez S, Viso A, Sánchez MG, Sánchez AM, Fernández C, Ramos JA, Hillard C, Lasunción MA, López-Rodríguez ML, Díaz-Laviada I) Br J Pharmacol 2004 Feb;141(3):457-67 PMID: 14718261 PMCID: PMC1574211 SCOPUS ID: 2-s2.0-10744227377 01/14/2004       33 Citations
  • Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. (Benito C, Núñez E, Tolón RM, Carrier EJ, Rábano A, Hillard CJ, Romero J) J Neurosci 2003 Dec 03;23(35):11136-41 PMID: 14657172 PMCID: PMC6741043 SCOPUS ID: 2-s2.0-0348010292 12/06/2003       408 Citations
  • Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition. (Seagard JL, Dean C, Patel S, Rademacher DJ, Hopp FA, Schmeling WT, Hillard CJ) Am J Physiol Heart Circ Physiol 2004 Mar;286(3):H992-1000 PMID: 14615281 SCOPUS ID: 2-s2.0-1342304201 11/15/2003       54 Citations
  • Cellular accumulation of anandamide: consensus and controversy. (Hillard CJ, Jarrahian A) Br J Pharmacol 2003 Nov;140(5):802-8 PMID: 12970089 PMCID: PMC1574088 SCOPUS ID: 2-s2.0-0344441315 09/13/2003       190 Citations
  • The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. (Patel S, Wohlfeil ER, Rademacher DJ, Carrier EJ, Perry LJ, Kundu A, Falck JR, Nithipatikom K, Campbell WB, Hillard CJ) Br J Pharmacol 2003 Jul;139(5):1005-13 PMID: 12839875 PMCID: PMC1573928 SCOPUS ID: 2-s2.0-10744224124 07/04/2003       111 Citations
  • Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. (Patel S, Rademacher DJ, Hillard CJ) J Pharmacol Exp Ther 2003 Sep;306(3):880-8 PMID: 12808005 SCOPUS ID: 2-s2.0-0041932370 06/17/2003       122 Citations
  • The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU. (Sato H, Frank DW, Hillard CJ, Feix JB, Pankhaniya RR, Moriyama K, Finck-Barbançon V, Buchaklian A, Lei M, Long RM, Wiener-Kronish J, Sawa T) EMBO J 2003 Jun 16;22(12):2959-69 PMID: 12805211 PMCID: PMC162142 SCOPUS ID: 2-s2.0-0038376087 06/14/2003       238 Citations
  • Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues. (El Fangour S, Balas L, Rossi JC, Fedenyuk A, Gretskaya N, Bobrov M, Bezuglov V, Hillard CJ, Durand T) Bioorg Med Chem Lett 2003 Jun 16;13(12):1977-80 PMID: 12781177 SCOPUS ID: 2-s2.0-0038440634 06/05/2003       7 Citations
  • 1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3. (Shang T, Uihlein AV, Van Asten J, Kalyanaraman B, Hillard CJ) J Neurochem 2003 Apr;85(2):358-67 PMID: 12675912 SCOPUS ID: 2-s2.0-0344406174 04/05/2003       63 Citations
  • Cannabinoid-induced Fos expression within A10 dopaminergic neurons. (Patel S, Hillard CJ) Brain Res 2003 Feb 14;963(1-2):15-25 PMID: 12560108 SCOPUS ID: 2-s2.0-0037435933 02/01/2003       53 Citations
  • 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide. (Kalivendi SV, Kotamraju S, Cunningham S, Shang T, Hillard CJ, Kalyanaraman B) Biochem J 2003 Apr 01;371(Pt 1):151-64 PMID: 12523938 PMCID: PMC1223270 SCOPUS ID: 2-s2.0-0037394420 01/14/2003       92 Citations
  • Microinjection of a cannabinoid receptor antagonist into the NTS increases baroreflex duration in dogs. (Rademacher DJ, Patel S, Hopp FA, Dean C, Hillard CJ, Seagard JL) Am J Physiol Heart Circ Physiol 2003 May;284(5):H1570-6 PMID: 12521935 SCOPUS ID: 2-s2.0-0037405166 01/11/2003       30 Citations
  • The CB1 receptor antagonist SR141716 enhances stimulus-induced activation of the primary somatosensory cortex of the rat. (Patel S, Gerrits R, Muthian S, Greene AS, Hillard CJ) Neurosci Lett 2002 Dec 25;335(2):95-8 PMID: 12459507 SCOPUS ID: 2-s2.0-0037176194 12/03/2002       12 Citations
  • Emesis, appetite, and endocannabinoids. (Inui A) Gastroenterology 2002 Aug;123(2):655; author reply 655-6 PMID: 12145832 SCOPUS ID: 2-s2.0-0036320664 07/30/2002    
  • Fatty acid amide hydrolase localization in the human central nervous system: an immunohistochemical study. (Romero J, Hillard CJ, Calero M, Rábano A) Brain Res Mol Brain Res 2002 Apr 30;100(1-2):85-93 PMID: 12008024 SCOPUS ID: 2-s2.0-0037197799 05/15/2002       64 Citations
  • Emesis, appetite, and endocannabinoids (Van Sickle M, Davison J, Sharkey K, Mackie K, Hillard C) Gastroenterology 2002;123(2):655-656 SCOPUS ID: 2-s2.0-85019984247 01/01/2002    
  • Cannabinoid-receptor-independent cell signalling by N-acylethanolamines. (Berdyshev EV, Schmid PC, Krebsbach RJ, Hillard CJ, Huang C, Chen N, Dong Z, Schmid HH) Biochem J 2001 Nov 15;360(Pt 1):67-75 PMID: 11695993 PMCID: PMC1222203 SCOPUS ID: 2-s2.0-0035890677 11/07/2001       67 Citations
  • Cannabinoid receptor agonists inhibit depolarization-induced calcium influx in cerebellar granule neurons. (Nogueron MI, Porgilsson B, Schneider WE, Stucky CL, Hillard CJ) J Neurochem 2001 Oct;79(2):371-81 PMID: 11677265 SCOPUS ID: 2-s2.0-0034775812 10/26/2001       33 Citations
  • Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret. (Van Sickle MD, Oland LD, Ho W, Hillard CJ, Mackie K, Davison JS, Sharkey KA) Gastroenterology 2001 Oct;121(4):767-74 PMID: 11606489 SCOPUS ID: 2-s2.0-0034791999 10/19/2001       181 Citations
  • Cannabinoid CB(1) receptor agonists produce cerebellar dysfunction in mice. (Patel S, Hillard CJ) J Pharmacol Exp Ther 2001 May;297(2):629-37 PMID: 11303052 SCOPUS ID: 2-s2.0-0035037811 04/17/2001       70 Citations
  • The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors. (Bisogno T, MacCarrone M, De Petrocellis L, Jarrahian A, Finazzi-Agrò A, Hillard C, Di Marzo V) Eur J Biochem 2001 Apr;268(7):1982-9 PMID: 11277920 SCOPUS ID: 2-s2.0-0034850220 03/30/2001       129 Citations
  • Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs. (Pratt PF, Li P, Hillard CJ, Kurian J, Campbell WB) Am J Physiol Heart Circ Physiol 2001 Mar;280(3):H1113-21 PMID: 11179054 SCOPUS ID: 2-s2.0-0034975475 02/17/2001       50 Citations
  • The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. (Deutsch DG, Glaser ST, Howell JM, Kunz JS, Puffenbarger RA, Hillard CJ, Abumrad N) J Biol Chem 2001 Mar 09;276(10):6967-73 PMID: 11118429 SCOPUS ID: 2-s2.0-0035831508 12/19/2000       191 Citations
  • The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes. (Hillard CJ, Jarrahian A) Chem Phys Lipids 2000 Nov;108(1-2):123-34 PMID: 11106786 SCOPUS ID: 2-s2.0-0033666960 12/07/2000       165 Citations
  • Inhibition of small intestinal secretion by cannabinoids is CB1 receptor-mediated in rats. (Tyler K, Hillard CJ, Greenwood-Van Meerveld B) Eur J Pharmacol 2000 Dec 08;409(2):207-11 PMID: 11104836 SCOPUS ID: 2-s2.0-0034624257 12/06/2000       51 Citations
  • Endocannabinoids and vascular function. (Hillard CJ) J Pharmacol Exp Ther 2000 Jul;294(1):27-32 PMID: 10871291 SCOPUS ID: 2-s2.0-0033917648 06/28/2000       144 Citations
  • Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter. (Jarrahian A, Manna S, Edgemond WS, Campbell WB, Hillard CJ) J Neurochem 2000 Jun;74(6):2597-606 PMID: 10820223 SCOPUS ID: 2-s2.0-0034070409 05/23/2000       127 Citations
  • Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol. (Hillard CJ) Prostaglandins Other Lipid Mediat 2000 Apr;61(1-2):3-18 PMID: 10785538 SCOPUS ID: 2-s2.0-0033998951 04/29/2000       180 Citations
  • Synthesis and characterization of a fluorescent substrate for the N-arachidonoylethanolamine (anandamide) transmembrane carrier. (Muthian S, Nithipatikom K, Campbell WB, Hillard CJ) J Pharmacol Exp Ther 2000 Apr;293(1):289-95 PMID: 10734181 SCOPUS ID: 2-s2.0-0034087481 03/29/2000       31 Citations
  • Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current (Gebremedhin D, Lange AR, Campbell WB, Hillard CJ, Harder DR) American Journal of Physiology 1999;276(6 PART 2) SCOPUS ID: 2-s2.0-33746492252 12/01/1999    
  • Effects of CB(1) cannabinoid receptor activation on cerebellar granule cell nitric oxide synthase activity. (Hillard CJ, Muthian S, Kearn CS) FEBS Lett 1999 Oct 08;459(2):277-81 PMID: 10518035 SCOPUS ID: 2-s2.0-0032830327 10/13/1999       84 Citations
  • Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current. (Gebremedhin D, Lange AR, Campbell WB, Hillard CJ, Harder DR) Am J Physiol 1999 06;276(6):H2085-93 PMID: 10362691 SCOPUS ID: 2-s2.0-0033002210 06/11/1999       213 Citations
  • Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange. (Kearn CS, Greenberg MJ, DiCamelli R, Kurzawa K, Hillard CJ) J Neurochem 1999 Jun;72(6):2379-87 PMID: 10349847 SCOPUS ID: 2-s2.0-0032973339 06/01/1999       97 Citations
  • Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). (Hillard CJ, Manna S, Greenberg MJ, DiCamelli R, Ross RA, Stevenson LA, Murphy V, Pertwee RG, Campbell WB) J Pharmacol Exp Ther 1999 Jun;289(3):1427-33 PMID: 10336536 SCOPUS ID: 2-s2.0-0033060910 05/21/1999       284 Citations
  • Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry. (Tsou K, Nogueron MI, Muthian S, Sañudo-Pena MC, Hillard CJ, Deutsch DG, Walker JM) Neurosci Lett 1998 Oct 02;254(3):137-40 PMID: 10214976 SCOPUS ID: 2-s2.0-0032476070 04/24/1999       214 Citations
  • Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivation. (Edgemond WS, Hillard CJ, Falck JR, Kearn CS, Campbell WB) Mol Pharmacol 1998 Jul;54(1):180-8 PMID: 9658204 SCOPUS ID: 2-s2.0-0031820286 07/11/1998       106 Citations
  • Synthesis and characterization of diazomethylarachidonyl ketone: an irreversible inhibitor of N-arachidonylethanolamine amidohydrolase. (Edgemond WS, Greenberg MJ, McGinley PJ, Muthian S, Campbell WB, Hillard CJ) J Pharmacol Exp Ther 1998 Jul;286(1):184-90 PMID: 9655859 SCOPUS ID: 2-s2.0-0031847458 07/10/1998       40 Citations
  • N-arachidonylethanolamide relaxation of bovine coronary artery is not mediated by CB1 cannabinoid receptor. (Pratt PF, Hillard CJ, Edgemond WS, Campbell WB) Am J Physiol 1998 01;274(1):H375-81 PMID: 9458889 SCOPUS ID: 2-s2.0-33750868226 02/12/1998       107 Citations
  • Biochemistry and pharmacology of arachidonylethanolamide, a putative endogenous cannabinoid. (Hillard CJ, Campbell WB) J Lipid Res 1997 Dec;38(12):2383-98 PMID: 9458263 SCOPUS ID: 2-s2.0-0031443586 02/11/1998       91 Citations
  • Arachidonylethanolamide (anandamide) binds with low affinity to dihydropyridine binding sites in brain membranes. (Jarrahian A, Hillard CJ) Prostaglandins Leukot Essent Fatty Acids 1997 Dec;57(6):551-4 PMID: 9431821 SCOPUS ID: 2-s2.0-0030827460 02/07/1998       24 Citations
  • Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion. (Hillard CJ, Edgemond WS, Jarrahian A, Campbell WB) J Neurochem 1997 Aug;69(2):631-8 PMID: 9231721 SCOPUS ID: 2-s2.0-0030852614 08/01/1997       304 Citations
  • The role of nitric oxide in the cerebrovascular response to hypercapnia. (Smith JJ, Lee JG, Hudetz AG, Hillard CJ, Bosnjak ZJ, Kampine JP) Anesth Analg 1997 Feb;84(2):363-9 PMID: 9024030 SCOPUS ID: 2-s2.0-0031057266 02/01/1997       22 Citations
  • Inhibitory effects of anandamide on ca2 + currents in cat cerebral arterial smooth muscle cells (Gebremedhin D, Campbell WB, Hillard CJ, Hantel DR) FASEB Journal 1996;10(3) SCOPUS ID: 2-s2.0-2642666507 12/01/1996    
  • Nicotinic cholinergic receptors (nAChR) are present on cerebellar granule cells and mediate calcium influx (Hillard CJ) FASEB Journal 1996;10(3) SCOPUS ID: 2-s2.0-33748968665 12/01/1996    
  • Immunocytes and abnormal gastrointestinal motor activity during ileitis in dogs. (Jouët P, Sarna SK, Singaram C, Ryan RP, Hillard CJ, Telford GL, Fink J, Henderson JD) Am J Physiol 1995 Dec;269(6 Pt 1):G913-24 PMID: 8572223 SCOPUS ID: 2-s2.0-0029616583 12/01/1995       35 Citations
  • Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain. (Hillard CJ, Wilkison DM, Edgemond WS, Campbell WB) Biochim Biophys Acta 1995 Aug 03;1257(3):249-56 PMID: 7647100 SCOPUS ID: 2-s2.0-0029133671 08/03/1995       207 Citations
  • Laser-Doppler measurement of the effects of halothane and isoflurane on the cerebrovascular CO2 response in the rat. (Lee JG, Smith JJ, Hudetz AG, Hillard CJ, Bosnjak ZJ, Kampine JP) Anesth Analg 1995 Apr;80(4):696-702 PMID: 7893020 SCOPUS ID: 2-s2.0-0028951335 04/01/1995       27 Citations
  • The binding of novel phenolic derivatives of anandamide to brain cannabinoid receptors. (Edgemond WS, Campbell WB, Hillard CJ) Prostaglandins Leukot Essent Fatty Acids 1995 Feb-Mar;52(2-3):83-6 PMID: 7784462 SCOPUS ID: 2-s2.0-0028800749 02/01/1995       27 Citations
  • Characterization of ligand binding to the cannabinoid receptor of rat brain membranes using a novel method: application to anandamide. (Hillard CJ, Edgemond WS, Campbell WB) J Neurochem 1995 Feb;64(2):677-83 PMID: 7830060 SCOPUS ID: 2-s2.0-0028813933 02/01/1995       73 Citations
  • The effects of halothane and isoflurane on cerebrocortical microcirculation and autoregulation as assessed by laser-Doppler flowmetry. (Lee JG, Hudetz AG, Smith JJ, Hillard CJ, Bosnjak ZJ, Kampine JP) Anesth Analg 1994 Jul;79(1):58-65 PMID: 8010455 SCOPUS ID: 2-s2.0-0028303715 07/01/1994       54 Citations
  • Decreased adrenal medullary catecholamine release in spontaneously diabetic BB-Wistar rats. Role of hypoglycemia. (Wilke RA, Hillard CJ) Diabetes 1994 May;43(5):724-9 PMID: 8168651 SCOPUS ID: 2-s2.0-0028278880 05/01/1994       20 Citations
  • In vitro activation of brain protein kinase C by the cannabinoids. (Hillard CJ, Auchampach JA) Biochim Biophys Acta 1994 Jan 13;1220(2):163-70 PMID: 8312360 SCOPUS ID: 2-s2.0-0028012276 01/13/1994       26 Citations
  • Decreased catecholamine secretion from the adrenal medullae of chronically diabetic BB-Wistar rats. (Wilke RA, Riley DA, Lelkes PI, Hillard CJ) Diabetes 1993 Jun;42(6):862-8 PMID: 8495810 SCOPUS ID: 2-s2.0-0027193761 06/01/1993       16 Citations
  • Effects of chronic nicotine treatment on the accumulation of [3H]tetraphenylphosphonium by cerebral cortical synaptosomes. (Hillard CJ, Pounds JJ) J Neurochem 1993 Feb;60(2):687-95 PMID: 8419544 SCOPUS ID: 2-s2.0-0027497595 02/01/1993       10 Citations
  • Role of guanylate cyclase-cGMP systems in halothane-induced vasodilation in canine cerebral arteries. (Eskinder H, Hillard CJ, Flynn N, Bosnjak ZJ, Kampine JP) Anesthesiology 1992 Sep;77(3):482-7 PMID: 1355637 SCOPUS ID: 2-s2.0-0026786912 09/01/1992       25 Citations
  • Nicotine-induced depolarization of cerebral cortical synaptosomes is dependent upon sodium. (Hillard CJ) Neuropharmacology 1992 Sep;31(9):909-14 PMID: 1436397 SCOPUS ID: 2-s2.0-0026649252 09/01/1992       4 Citations
  • [3H]tetraphenylphosphonium accumulation in cerebral cortical synaptosomes as a measure of nicotine-induced changes in membrane potential. (Hillard CJ, Pounds JJ) J Pharmacol Exp Ther 1991 Dec;259(3):1118-23 PMID: 1762066 SCOPUS ID: 2-s2.0-0026357502 12/01/1991       8 Citations
  • Studies of the effect of nicotine on synaptosomal calcium accumulation using FURA-2. (Hillard CJ, Graf WK) NIDA Res Monogr 1990;105:331-2 PMID: 1876032 SCOPUS ID: 2-s2.0-0025569911 01/01/1991       6 Citations
  • Comparison of the vasodilation and inhibition of phosphatidylinositol hydrolysis produced by KT-362 and TMB-8 in canine femoral artery (Hillard CJ, Hruz PW, Gross GJ) Journal of Vascular Medicine and Biology 1991;3(1):1-4 SCOPUS ID: 2-s2.0-0025822876 01/01/1991    
  • Studies of the role of membrane lipid order in the effects of delta 9-tetrahydrocannabinol on adenylate cyclase activation in heart. (Hillard CJ, Pounds JJ, Boyer DR, Bloom AS) J Pharmacol Exp Ther 1990 Mar;252(3):1075-82 PMID: 2156989 SCOPUS ID: 2-s2.0-0025257436 03/01/1990       24 Citations
  • Effect of KT-362, a putative intracellular calcium antagonist, on norepinephrine-induced contractions and inositol monophosphate accumulation in canine femoral artery. (Eskinder H, Hillard CJ, Wilke RA, Gross GJ) J Cardiovasc Pharmacol 1989 Mar;13(3):502-7 PMID: 2471898 SCOPUS ID: 2-s2.0-0024582073 03/01/1989       15 Citations
  • Alpha adrenoceptor subtypes and receptor reserve in human versus canine saphenous vein: sensitivity to blockade by nitroglycerin. (Eskinder H, Hillard CJ, Olinger GN, Christensen CW, Baker JE, Warltier DC, Gross GJ) J Pharmacol Exp Ther 1988 Dec;247(3):941-8 PMID: 2905005 SCOPUS ID: 2-s2.0-0024269976 12/01/1988       9 Citations
  • Effects of delta 9-tetrahydrocannabinol on glucagon receptor coupling to adenylate cyclase in rat liver plasma membranes. (Hillard CJ, Bloom AS, Houslay MD) Biochem Pharmacol 1986 Aug 15;35(16):2797-803 PMID: 3017362 SCOPUS ID: 2-s2.0-0022505707 08/15/1986       16 Citations
  • Effects of the cannabinoids on physical properties of brain membranes and phospholipid vesicles: fluorescence studies. (Hillard CJ, Harris RA, Bloom AS) J Pharmacol Exp Ther 1985 Mar;232(3):579-88 PMID: 2983062 SCOPUS ID: 2-s2.0-0021929098 03/01/1985       79 Citations
  • The effects of delta 9-tetrahydrocannabinol on serum thyrotropin levels in the rat. (Hillard CJ, Farber NE, Hagen TC, Bloom AS) Pharmacol Biochem Behav 1984 Apr;20(4):547-50 PMID: 6328543 SCOPUS ID: 2-s2.0-0021344416 04/01/1984       25 Citations
  • The effects of cannabinoids on fluidity of brain synaptic membranes (Hillard CJ, Harris RA, Bloom AS) Federation Proceedings 1984;43(4) SCOPUS ID: 2-s2.0-0021137132 01/01/1984    
  • Possible role of prostaglandins in the effects of the cannabinoids on adenylate cyclase activity. (Hillard CJ, Bloom AS) Eur J Pharmacol 1983 Jul 15;91(1):21-7 PMID: 6311573 SCOPUS ID: 2-s2.0-0020595620 07/15/1983       20 Citations
  • delta 9-Tetrahydrocannabinol-induced changes in beta-adrenergic receptor binding in mouse cerebral cortex. (Hillard CJ, Bloom AS) Brain Res 1982 Mar 11;235(2):370-7 PMID: 6329417 SCOPUS ID: 2-s2.0-0020059703 03/11/1982       26 Citations
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