Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 1998 May 29;93(5):841-50
Date
06/18/1998Pubmed ID
9630227DOI
10.1016/s0092-8674(00)81444-0Scopus ID
2-s2.0-0000943469 (requires institutional sign-in at Scopus site) 1110 CitationsAbstract
A variety of cytokines mediate the activation of Janus protein tyrosine kinases (Jaks). The Jaks then phosphorylate cellular substrates, including members of the signal transducers and activators of transcription (Stat) family of transcription factors. Among the Stats, the two highly related proteins, Stat5a and Stat5b, are activated by a variety of cytokines. To assess the role of the Stat5 proteins, mutant mice were derived that have the genes deleted individually or together. The phenotypes of the mice demonstrate an essential, and often redundant, role for the two Stat5 proteins in a spectrum of physiological responses associated with growth hormone and prolactin. Conversely, the responses to a variety of cytokines that activate the Stat5 proteins, including erythropoietin, are largely unaffected.
Author List
Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, Brown M, Bodner S, Grosveld G, Ihle JNAuthor
Demin Wang PhD Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBody Constitution
Cytokines
DNA-Binding Proteins
Erythropoietin
Female
Gene Deletion
Growth Hormone
Hematopoiesis
Infertility, Female
Mammary Glands, Animal
Mice
Mice, Mutant Strains
Milk Proteins
Ovary
Prolactin
STAT5 Transcription Factor
Trans-Activators
