Treatment of a CNS relapse while on therapy for Burkitt lymphoma. Pediatr Blood Cancer 2009 Feb;52(2):290-2
Date
10/22/2008Pubmed ID
18937319DOI
10.1002/pbc.21794Scopus ID
2-s2.0-59449110216 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
The treatment of Burkitt lymphoma (BL) has come a long way in regards to survival, with the majority of even the advanced stage patients being cured. The prognosis for relapsed BL remains dismal, despite attempts to further intensify therapy. We report on a patient with advanced stage BL who relapsed in the CNS while on therapy. The patient was successfully treated with an intensified regimen based on a concentration times time (C x T) CNS-directed model. Our experience shows both the feasibility and efficacy of such an approach in a patient with an otherwise very poor prognosis.
Author List
Burke MJ, Dayton VAuthor
Michael James Burke MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Burkitt LymphomaCentral Nervous System Neoplasms
Child
Dose-Response Relationship, Drug
Humans
Male
Recurrence
Treatment Outcome