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Treatment of a CNS relapse while on therapy for Burkitt lymphoma. Pediatr Blood Cancer 2009 Feb;52(2):290-2

Date

10/22/2008

Pubmed ID

18937319

DOI

10.1002/pbc.21794

Scopus ID

2-s2.0-59449110216   2 Citations

Abstract

The treatment of Burkitt lymphoma (BL) has come a long way in regards to survival, with the majority of even the advanced stage patients being cured. The prognosis for relapsed BL remains dismal, despite attempts to further intensify therapy. We report on a patient with advanced stage BL who relapsed in the CNS while on therapy. The patient was successfully treated with an intensified regimen based on a concentration times time (C x T) CNS-directed model. Our experience shows both the feasibility and efficacy of such an approach in a patient with an otherwise very poor prognosis.

Author List

Burke MJ, Dayton V

Author

Michael James Burke MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Burkitt Lymphoma
Central Nervous System Neoplasms
Child
Dose-Response Relationship, Drug
Humans
Male
Recurrence
Treatment Outcome
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a