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Cardiomyocyte Polyploidy and Implications for Heart Regeneration. Annu Rev Physiol 2020 02 10;82:45-61

Date

10/06/2019

Pubmed ID

31585517

DOI

10.1146/annurev-physiol-021119-034618

Abstract

In mammals, most cardiomyocytes (CMs) become polyploid (they have more than two complete sets of chromosomes). The purpose of this review is to evaluate assumptions about CM ploidy that are commonly discussed, even if not experimentally demonstrated, and to highlight key issues that are still to be resolved. Topics discussed here include (a) technical and conceptual difficulties in defining a polyploid CM, (b) the candidate role of reactive oxygen as a proximal trigger for the onset of polyploidy, (c) the relationship between polyploidization and other aspects of CM maturation, (d) recent insights related to the regenerative role of the subpopulation of CMs that are not polyploid, and (e) speculations as to why CMs become polyploid at all. New approaches to experimentally manipulate CM ploidy may resolve some of these long-standing and fundamental questions.

Author List

Gan P, Patterson M, Sucov HM

Author

Michaela Patterson PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Cell Proliferation
Humans
Myocardium
Myocytes, Cardiac
Polyploidy
Regeneration