Medical College of Wisconsin
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Michaela Patterson PhD

Michaela Patterson PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Cell Biology Neurobiology and Anatomy

Member of the Cardiovascular Research Center

View Curriculum Vitae

Research Areas of Interest

  • Cell Differentiation
  • Cell Proliferation
  • Diploidy
  • Heart
  • Mice, Knockout
  • Myocardium
  • Myocytes, Cardiac
  • Polyploidy
  • Regeneration

    • Publications (33)

  • Genome-wide association mapping and targeted loss of function studies identify Shroom3 as a driver of hyperpolyploidy and ventricular dilation. (Purdy AL, Bakhshian Nik A, Arkatkar AA, Hasan P, Flinn MA, Choudhury P, Wood C, Takizawa A, Malloy L, Tutaj M, Drysdale TA, Bridgewater D, Link BA, Plageman TF Jr, Kwitek AE, Dwinell MR, Saba LM, O'Meara CC, Patterson M) Proc Natl Acad Sci U S A 2026 Jun 02;123(22):e2522068123 PMID: 42189988 PMCID: PMC13229193 SCOPUS ID: 2-s2.0-105040415970 05/26/2026       1 Citation
  • Runx1 in Postn-Expressing Fibroblasts But Not Cardiomyocytes Exacerbates Adverse Cardiac Remodeling Post-Myocardial Infarction. (Akins KA, Arkatkar A, Flinn MA, Sandor N, Purdy AL, Brusacoram AL, Swift SK, Buday S, Choudhury P, Cui M, Lin BL, O'Meara CC, Patterson M) JACC Basic Transl Sci 2026 Feb;11(2):101455 PMID: 41534459 PMCID: PMC12830150 SCOPUS ID: 2-s2.0-105027428206 01/15/2026       1 Citation
  • Novel insights into post-myocardial infarction cardiac remodeling through algorithmic detection of cell-type composition shifts. (Gural B, Kirkland L, Hockett A, Sandroni P, Zhang J, Rosa-Garrido M, Swift SK, Chapski DJ, Flinn MA, O'Meara CC, Vondriska TM, Patterson M, Jensen BC, Rau CD) PLoS Genet 2025 Jul;21(7):e1011807 PMID: 40705823 PMCID: PMC12309993 SCOPUS ID: 2-s2.0-105011521361 07/24/2025       3 Citations
  • Protocol for quantifying murine cardiomyocyte cell division by single-cell suspension. (Swift SK, Purdy AL, Patterson M) STAR Protoc 2024 Dec 20;5(4):103452 PMID: 39520685 PMCID: PMC11585686 SCOPUS ID: 2-s2.0-85208464410 11/13/2024       2 Citations
  • A broadly applicable method for quantifying cardiomyocyte cell division identifies proliferative events following myocardial infarction. (Swift SK, Purdy AL, Buddell T, Lovett JJ, Chanjeevaram SV, Arkatkar A, O'Meara CC, Patterson M) Cell Rep Methods 2024 Sep 16;4(9):100860 PMID: 39255794 PMCID: PMC11440799 SCOPUS ID: 2-s2.0-85204511356 09/11/2024       6 Citations
  • Novel Insights into Post-Myocardial Infarction Cardiac Remodeling through Algorithmic Detection of Cell-Type Composition Shifts. (Gural B, Kirkland L, Hockett A, Sandroni P, Zhang J, Rosa-Garrido M, Swift SK, Chapski D, Flinn MA, O'Meara CC, Vondriska TM, Patterson M, Jensen BC, Rau CD) bioRxiv 2024 Aug 10 PMID: 39149394 PMCID: PMC11326268 08/16/2024    
  • Runx1 is sufficient but not required for cardiomyocyte cell-cycle activation. (Akins KA, Flinn MA, Swift SK, Chanjeevaram SV, Purdy AL, Buddell T, Kolell ME, Andresen KG, Paddock S, Buday SL, Veldman MB, O'Meara CC, Patterson M) Am J Physiol Heart Circ Physiol 2024 Aug 01;327(2):H377-H389 PMID: 38847758 PMCID: PMC11442100 SCOPUS ID: 2-s2.0-85199812831 06/07/2024       7 Citations
  • The genetics of cardiomyocyte polyploidy. (Buddell T, Purdy AL, Patterson M) Curr Top Dev Biol 2024;156:245-295 PMID: 38556425 SCOPUS ID: 2-s2.0-85184583777 04/01/2024       5 Citations
  • Global IL4Rα blockade exacerbates heart failure after an ischemic event in mice and humans. (Alvarez-Argote S, Almeida VA, Knas MC, Buday SL, Patterson M, O'Meara CC) Am J Physiol Heart Circ Physiol 2024 May 01;326(5):H1080-H1093 PMID: 38426866 PMCID: PMC11380969 SCOPUS ID: 2-s2.0-85190400498 03/01/2024       7 Citations
  • IL-13 promotes functional recovery after myocardial infarction via direct signaling to macrophages. (Alvarez-Argote S, Paddock SJ, Flinn MA, Moreno CW, Knas MC, Almeida VA, Buday SL, Bakhshian Nik A, Patterson M, Chen YG, Lin CW, O'Meara CC) JCI Insight 2024 Jan 23;9(2) PMID: 38051583 PMCID: PMC10906228 SCOPUS ID: 2-s2.0-85183312687 12/06/2023       18 Citations
  • Tnni3k influences cardiomyocyte S-phase activity and proliferation. (Purdy AL, Swift SK, Sucov HM, Patterson M) J Mol Cell Cardiol 2023 Oct;183:22-26 PMID: 37597489 PMCID: PMC11645536 SCOPUS ID: 2-s2.0-85168365327 08/20/2023       8 Citations
  • Myofibroblast Ccn3 is regulated by Yap and Wwtr1 and contributes to adverse cardiac outcomes. (Flinn MA, Alvarez-Argote S, Knas MC, Almeida VA, Paddock SJ, Zhou X, Buddell T, Jamal A, Taylor R, Liu P, Drnevich J, Patterson M, Link BA, O'Meara CC) Front Cardiovasc Med 2023;10:1142612 PMID: 36998974 PMCID: PMC10043314 SCOPUS ID: 2-s2.0-85150879131 04/01/2023       10 Citations
  • Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds. (Swift SK, Purdy AL, Kolell ME, Andresen KG, Lahue C, Buddell T, Akins KA, Rau CD, O'Meara CC, Patterson M) Development 2023 Apr 01;150(7) PMID: 36912240 PMCID: PMC10113957 SCOPUS ID: 2-s2.0-85152488769 03/14/2023       32 Citations
  • Measuring cardiomyocyte cell-cycle activity and proliferation in the age of heart regeneration. (Auchampach J, Han L, Huang GN, Kühn B, Lough JW, O'Meara CC, Payumo AY, Rosenthal NA, Sucov HM, Yutzey KE, Patterson M) Am J Physiol Heart Circ Physiol 2022 Apr 01;322(4):H579-H596 PMID: 35179974 PMCID: PMC8934681 SCOPUS ID: 2-s2.0-85127729067 02/19/2022       38 Citations
  • Conditional depletion of the acetyltransferase Tip60 protects against the damaging effects of myocardial infarction. (Wang X, Wan TC, Lauth A, Purdy AL, Kulik KR, Patterson M, Lough JW, Auchampach JA) J Mol Cell Cardiol 2022 Feb;163:9-19 PMID: 34610340 PMCID: PMC8816866 SCOPUS ID: 2-s2.0-85116932867 10/06/2021       16 Citations
  • IL4Rα signaling promotes neonatal cardiac regeneration and cardiomyocyte cell cycle activity. (Paddock SJ, Swift SK, Alencar-Almeida V, Kenarsary A, Alvarez-Argote S, Flinn MA, Patterson M, O'Meara CC) J Mol Cell Cardiol 2021 Dec;161:62-74 PMID: 34343540 PMCID: PMC8629844 SCOPUS ID: 2-s2.0-85112431618 08/04/2021       21 Citations
  • Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes. (Wang X, Lupton C, Lauth A, Wan TC, Foster P, Patterson M, Auchampach JA, Lough JW) J Mol Cell Cardiol 2021 Jun;155:88-98 PMID: 33609538 PMCID: PMC8154663 SCOPUS ID: 2-s2.0-85102458794 02/21/2021       12 Citations
  • Introductions to the Community: Early-Career Researchers in the Time of COVID-19. Cell Stem Cell 2020 Jul 02;27(1):13-14 PMID: 32619510 PMCID: PMC7331526 SCOPUS ID: 2-s2.0-85087474163 07/04/2020    
  • Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy. (Gan P, Patterson M, Watanabe H, Wang K, Edmonds RA, Reinholdt LG, Sucov HM) Sci Rep 2020 May 05;10(1):7605 PMID: 32371981 PMCID: PMC7200697 SCOPUS ID: 2-s2.0-85084327709 05/07/2020       11 Citations
  • Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling. (Shen H, Gan P, Wang K, Darehzereshki A, Wang K, Kumar SR, Lien CL, Patterson M, Tao G, Sucov HM) Elife 2020 Mar 13;9 PMID: 32167474 PMCID: PMC7105374 SCOPUS ID: 2-s2.0-85082563460 03/14/2020       41 Citations
  • Residual Diploidy in Polyploid Tissues: A Cellular State with Enhanced Proliferative Capacity for Tissue Regeneration? (Patterson M, Swift SK) Stem Cells Dev 2019 Dec 01;28(23):1527-1539 PMID: 31608782 PMCID: PMC11001963 SCOPUS ID: 2-s2.0-85075961806 10/15/2019       21 Citations
  • Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency. (Gan P, Patterson M, Velasquez A, Wang K, Tian D, Windle JJ, Tao G, Judge DP, Makita T, Park TJ, Sucov HM) PLoS Genet 2019 Oct;15(10):e1008354 PMID: 31589606 PMCID: PMC6797218 SCOPUS ID: 2-s2.0-85073578062 10/08/2019       30 Citations
  • Cardiomyocyte Polyploidy and Implications for Heart Regeneration. (Gan P, Patterson M, Sucov HM) Annu Rev Physiol 2020 Feb 10;82:45-61 PMID: 31585517 SCOPUS ID: 2-s2.0-85079204000 10/06/2019       77 Citations
  • Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. (Patterson M, Barske L, Van Handel B, Rau CD, Gan P, Sharma A, Parikh S, Denholtz M, Huang Y, Yamaguchi Y, Shen H, Allayee H, Crump JG, Force TI, Lien CL, Makita T, Lusis AJ, Kumar SR, Sucov HM) Nat Genet 2017 Sep;49(9):1346-1353 PMID: 28783163 PMCID: PMC5736145 SCOPUS ID: 2-s2.0-85028707436 08/08/2017       276 Citations
  • Adipogenesis and epicardial adipose tissue: a novel fate of the epicardium induced by mesenchymal transformation and PPARγ activation. (Yamaguchi Y, Cavallero S, Patterson M, Shen H, Xu J, Kumar SR, Sucov HM) Proc Natl Acad Sci U S A 2015 Feb 17;112(7):2070-5 PMID: 25646471 PMCID: PMC4343131 SCOPUS ID: 2-s2.0-84923166412 02/04/2015       147 Citations
  • let-7 miRNAs can act through notch to regulate human gliogenesis. (Patterson M, Gaeta X, Loo K, Edwards M, Smale S, Cinkornpumin J, Xie Y, Listgarten J, Azghadi S, Douglass SM, Pellegrini M, Lowry WE) Stem Cell Reports 2014 Nov 11;3(5):758-73 PMID: 25316189 PMCID: PMC4235151 SCOPUS ID: 2-s2.0-84922586737 10/16/2014       95 Citations
  • From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols. (Karumbayaram S, Lee P, Azghadi SF, Cooper AR, Patterson M, Kohn DB, Pyle A, Clark A, Byrne J, Zack JA, Plath K, Lowry WE) Stem Cells Transl Med 2012 Jan;1(1):36-43 PMID: 23197638 PMCID: PMC3727693 SCOPUS ID: 2-s2.0-84863734269 12/01/2012       45 Citations
  • Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo. (Palomares K, Vigant F, Van Handel B, Pernet O, Chikere K, Hong P, Sherman SP, Patterson M, An DS, Lowry WE, Mikkola HK, Morizono K, Pyle AD, Lee B) J Virol 2013 Feb;87(4):2094-108 PMID: 23192877 PMCID: PMC3571488 SCOPUS ID: 2-s2.0-84873834467 11/30/2012       47 Citations
  • Dynamic distribution of linker histone H1.5 in cellular differentiation. (Li JY, Patterson M, Mikkola HK, Lowry WE, Kurdistani SK) PLoS Genet 2012;8(8):e1002879 PMID: 22956909 PMCID: PMC3431313 SCOPUS ID: 2-s2.0-84866170632 09/08/2012       66 Citations
  • Physically associated synthetic hydrogels with long-term covalent stabilization for cell culture and stem cell transplantation. (Zhang J, Tokatlian T, Zhong J, Ng QK, Patterson M, Lowry WE, Carmichael ST, Segura T) Adv Mater 2011 Nov 16;23(43):5098-103 PMID: 21997799 PMCID: PMC3242734 SCOPUS ID: 2-s2.0-81255163409 10/15/2011       57 Citations
  • Defining the nature of human pluripotent stem cell progeny. (Patterson M, Chan DN, Ha I, Case D, Cui Y, Van Handel B, Mikkola HK, Lowry WE) Cell Res 2012 Jan;22(1):178-93 PMID: 21844894 PMCID: PMC3351932 SCOPUS ID: 2-s2.0-84855484998 08/17/2011       123 Citations
  • Female human iPSCs retain an inactive X chromosome. (Tchieu J, Kuoy E, Chin MH, Trinh H, Patterson M, Sherman SP, Aimiuwu O, Lindgren A, Hakimian S, Zack JA, Clark AT, Pyle AD, Lowry WE, Plath K) Cell Stem Cell 2010 Sep 03;7(3):329-42 PMID: 20727844 PMCID: PMC2935700 SCOPUS ID: 2-s2.0-77956222202 08/24/2010       244 Citations
  • Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. (Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE) Stem Cells 2009 Apr;27(4):806-11 PMID: 19350680 PMCID: PMC2895909 SCOPUS ID: 2-s2.0-65649115029 04/08/2009       335 Citations
    • Last update: 06/29/2026