Medical College of Wisconsin
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Michaela Patterson PhD

Michaela Patterson PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cardiovascular Center

View Curriculum Vitae

Research Areas of Interest

  • Cell Differentiation
  • Cell Proliferation
  • Diploidy
  • Heart
  • Mice, Knockout
  • Myocardium
  • Myocytes, Cardiac
  • Polyploidy
  • Regeneration

    • Publications (21)

  • Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds. (Swift SK, Purdy AL, Kolell ME, Andresen KG, Lahue C, Buddell T, Akins KA, Rau CD, O'Meara CC, Patterson M) Development 2023 Apr 01;150(7) PMID: 36912240 PMCID: PMC10113957 SCOPUS ID: 2-s2.0-85152488769 03/14/2023       10 Citations
  • Measuring cardiomyocyte cell-cycle activity and proliferation in the age of heart regeneration. (Auchampach J, Han L, Huang GN, Kühn B, Lough JW, O'Meara CC, Payumo AY, Rosenthal NA, Sucov HM, Yutzey KE, Patterson M) Am J Physiol Heart Circ Physiol 2022 Apr 01;322(4):H579-H596 PMID: 35179974 PMCID: PMC8934681 SCOPUS ID: 2-s2.0-85127729067 02/19/2022       17 Citations
  • Conditional depletion of the acetyltransferase Tip60 protects against the damaging effects of myocardial infarction. (Wang X, Wan TC, Lauth A, Purdy AL, Kulik KR, Patterson M, Lough JW, Auchampach JA) J Mol Cell Cardiol 2022 Feb;163:9-19 PMID: 34610340 PMCID: PMC8816866 SCOPUS ID: 2-s2.0-85116932867 10/06/2021       8 Citations
  • IL4Rα signaling promotes neonatal cardiac regeneration and cardiomyocyte cell cycle activity. (Paddock SJ, Swift SK, Alencar-Almeida V, Kenarsary A, Alvarez-Argote S, Flinn MA, Patterson M, O'Meara CC) J Mol Cell Cardiol 2021 Dec;161:62-74 PMID: 34343540 PMCID: PMC8629844 SCOPUS ID: 2-s2.0-85112431618 08/04/2021       10 Citations
  • Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes. (Wang X, Lupton C, Lauth A, Wan TC, Foster P, Patterson M, Auchampach JA, Lough JW) J Mol Cell Cardiol 2021 Jun;155:88-98 PMID: 33609538 PMCID: PMC8154663 SCOPUS ID: 2-s2.0-85102458794 02/21/2021       8 Citations
  • Introductions to the Community: Early-Career Researchers in the Time of COVID-19. Cell Stem Cell 2020 Jul 02;27(1):13-14 PMID: 32619510 PMCID: PMC7331526 SCOPUS ID: 2-s2.0-85087474163 07/04/2020    
  • Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy. (Gan P, Patterson M, Watanabe H, Wang K, Edmonds RA, Reinholdt LG, Sucov HM) Sci Rep 2020 May 05;10(1):7605 PMID: 32371981 PMCID: PMC7200697 SCOPUS ID: 2-s2.0-85084327709 05/07/2020       8 Citations
  • Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling. (Shen H, Gan P, Wang K, Darehzereshki A, Wang K, Kumar SR, Lien CL, Patterson M, Tao G, Sucov HM) Elife 2020 Mar 13;9 PMID: 32167474 PMCID: PMC7105374 SCOPUS ID: 2-s2.0-85082563460 03/14/2020       25 Citations
  • Residual Diploidy in Polyploid Tissues: A Cellular State with Enhanced Proliferative Capacity for Tissue Regeneration? (Patterson M, Swift SK) Stem Cells Dev 2019 Dec 01;28(23):1527-1539 PMID: 31608782 PMCID: PMC11001963 SCOPUS ID: 2-s2.0-85075961806 10/15/2019       15 Citations
  • Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency. (Gan P, Patterson M, Velasquez A, Wang K, Tian D, Windle JJ, Tao G, Judge DP, Makita T, Park TJ, Sucov HM) PLoS Genet 2019 Oct;15(10):e1008354 PMID: 31589606 PMCID: PMC6797218 SCOPUS ID: 2-s2.0-85073578062 10/08/2019       25 Citations
  • Cardiomyocyte Polyploidy and Implications for Heart Regeneration. (Gan P, Patterson M, Sucov HM) Annu Rev Physiol 2020 Feb 10;82:45-61 PMID: 31585517 SCOPUS ID: 2-s2.0-85079204000 10/06/2019       59 Citations
  • Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. (Patterson M, Barske L, Van Handel B, Rau CD, Gan P, Sharma A, Parikh S, Denholtz M, Huang Y, Yamaguchi Y, Shen H, Allayee H, Crump JG, Force TI, Lien CL, Makita T, Lusis AJ, Kumar SR, Sucov HM) Nat Genet 2017 Sep;49(9):1346-1353 PMID: 28783163 PMCID: PMC5736145 SCOPUS ID: 2-s2.0-85028707436 08/08/2017       220 Citations
  • Adipogenesis and epicardial adipose tissue: a novel fate of the epicardium induced by mesenchymal transformation and PPARγ activation. (Yamaguchi Y, Cavallero S, Patterson M, Shen H, Xu J, Kumar SR, Sucov HM) Proc Natl Acad Sci U S A 2015 Feb 17;112(7):2070-5 PMID: 25646471 PMCID: PMC4343131 SCOPUS ID: 2-s2.0-84923166412 02/04/2015       108 Citations
  • let-7 miRNAs can act through notch to regulate human gliogenesis. (Patterson M, Gaeta X, Loo K, Edwards M, Smale S, Cinkornpumin J, Xie Y, Listgarten J, Azghadi S, Douglass SM, Pellegrini M, Lowry WE) Stem Cell Reports 2014 Nov 11;3(5):758-73 PMID: 25316189 PMCID: PMC4235151 SCOPUS ID: 2-s2.0-84922586737 10/16/2014       83 Citations
  • From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols. (Karumbayaram S, Lee P, Azghadi SF, Cooper AR, Patterson M, Kohn DB, Pyle A, Clark A, Byrne J, Zack JA, Plath K, Lowry WE) Stem Cells Transl Med 2012 Jan;1(1):36-43 PMID: 23197638 PMCID: PMC3727693 SCOPUS ID: 2-s2.0-84863734269 12/01/2012       43 Citations
  • Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo. (Palomares K, Vigant F, Van Handel B, Pernet O, Chikere K, Hong P, Sherman SP, Patterson M, An DS, Lowry WE, Mikkola HK, Morizono K, Pyle AD, Lee B) J Virol 2013 Feb;87(4):2094-108 PMID: 23192877 PMCID: PMC3571488 SCOPUS ID: 2-s2.0-84873834467 11/30/2012       28 Citations
  • Dynamic distribution of linker histone H1.5 in cellular differentiation. (Li JY, Patterson M, Mikkola HK, Lowry WE, Kurdistani SK) PLoS Genet 2012;8(8):e1002879 PMID: 22956909 PMCID: PMC3431313 SCOPUS ID: 2-s2.0-84866170632 09/08/2012       61 Citations
  • Physically associated synthetic hydrogels with long-term covalent stabilization for cell culture and stem cell transplantation. (Zhang J, Tokatlian T, Zhong J, Ng QK, Patterson M, Lowry WE, Carmichael ST, Segura T) Adv Mater 2011 Nov 16;23(43):5098-103 PMID: 21997799 PMCID: PMC3242734 SCOPUS ID: 2-s2.0-81255163409 10/15/2011       50 Citations
  • Defining the nature of human pluripotent stem cell progeny. (Patterson M, Chan DN, Ha I, Case D, Cui Y, Van Handel B, Mikkola HK, Lowry WE) Cell Res 2012 Jan;22(1):178-93 PMID: 21844894 PMCID: PMC3351932 SCOPUS ID: 2-s2.0-84855484998 08/17/2011       108 Citations
  • Female human iPSCs retain an inactive X chromosome. (Tchieu J, Kuoy E, Chin MH, Trinh H, Patterson M, Sherman SP, Aimiuwu O, Lindgren A, Hakimian S, Zack JA, Clark AT, Pyle AD, Lowry WE, Plath K) Cell Stem Cell 2010 Sep 03;7(3):329-42 PMID: 20727844 PMCID: PMC2935700 SCOPUS ID: 2-s2.0-77956222202 08/24/2010       223 Citations
  • Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. (Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE) Stem Cells 2009 Apr;27(4):806-11 PMID: 19350680 PMCID: PMC2895909 SCOPUS ID: 2-s2.0-65649115029 04/08/2009       322 Citations
    • Last update: 03/28/2023