Faculty Collaboration Database

Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor. FEBS Lett 1993 Sep 13;330(2):181-5

Date

09/13/1993

Pubmed ID

8365489

DOI

10.1016/0014-5793(93)80269-z

Scopus ID

2-s2.0-0027162279 (requires institutional sign-in at Scopus site)   258 Citations

Abstract

Peroxynitrite is an oxidant which could be formed in the vasculature by the reaction of superoxide with nitric oxide. It is capable of modifying amino acid residues and of initiating lipid peroxidation. In the present study we have shown that peroxynitrite converts low density lipoprotein to a form recognized by the macrophage scavenger receptor and that this process is associated with modification of the protein and lipid, and with the oxidation of alpha-tocopherol to alpha-tocopherol quinone.

Author List

Graham A, Hogg N, Kalyanaraman B, O'Leary V, Darley-Usmar V, Moncada S

Authors

Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of Wisconsin
Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Cell Line
Humans
Lipoproteins, LDL
Macrophages
Membrane Proteins
Nitrates
Oxidation-Reduction
Receptors, Immunologic
Receptors, Lipoprotein
Receptors, Scavenger
Scavenger Receptors, Class B
Vitamin E