Regression on oxymetholone-induced hepatic tumors after bone marrow transplantation in aplastic anemia. Transplantation 1980 Aug;30(2):90-6
Date
08/01/1980Pubmed ID
7010713DOI
10.1097/00007890-198008000-00002Scopus ID
2-s2.0-0018821928 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
Treatment of acquired aplastic anemia with androgens has been occasionally associated with the development of hepatic tumors. We have studied a 13-year-old boy with idiopathic aplastic anemia in whom oxymetholone treatment was associated with a partial hematological remission. Thirty-four months later, however, the patient developed multiple hepatic tumors. When oxymetholone therapy was discontinued, the aplastic anemia relapsed. He then underwent bone marrow transplantation from his HLA-A, B, and D-compatible sibling. This was followed by hematological and immunological reconstitution. The hepatic tumors underwent progressive regression after bone marrow transplantation. The patient is now 3 years post-bone marrow transplantation and is in complete remission of his aplastic anemia with no evidence of detectable liver tumors.
Author List
Montgomery RR, Ducore JM, Githens JH, August CS, Johnson MLAuthor
Robert R. Montgomery MD Adjunct Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAnemia, Aplastic
Bone Marrow Transplantation
Humans
Liver Neoplasms
Male
Oxymetholone
Transplantation, Homologous
Ultrasonography
