Modeling Human Cancer-induced Cachexia. Cell Rep 2019 Aug 06;28(6):1612-1622.e4
Date
08/08/2019Pubmed ID
31390573Pubmed Central ID
PMC6733019DOI
10.1016/j.celrep.2019.07.016Scopus ID
2-s2.0-85069958981 (requires institutional sign-in at Scopus site) 80 CitationsAbstract
Cachexia is a wasting syndrome characterized by pronounced skeletal muscle loss. In cancer, cachexia is associated with increased morbidity and mortality and decreased treatment tolerance. Although advances have been made in understanding the mechanisms of cachexia, translating these advances to the clinic has been challenging. One reason for this shortcoming may be the current animal models, which fail to fully recapitulate the etiology of human cancer-induced tissue wasting. Because pancreatic ductal adenocarcinoma (PDA) presents with a high incidence of cachexia, we engineered a mouse model of PDA that we named KPP. KPP mice, similar to PDA patients, progressively lose skeletal and adipose mass as a consequence of their tumors. In addition, KPP muscles exhibit a similar gene ontology as cachectic patients. We envision that the KPP model will be a useful resource for advancing our mechanistic understanding and ability to treat cancer cachexia.
Author List
Talbert EE, Cuitiño MC, Ladner KJ, Rajasekerea PV, Siebert M, Shakya R, Leone GW, Ostrowski MC, Paleo B, Weisleder N, Reiser PJ, Webb A, Timmers CD, Eiferman DS, Evans DC, Dillhoff ME, Schmidt CR, Guttridge DCAuthor
Gustavo Leone PhD Sr Associate Dean, Director, Professor in the Biochemistry department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCachexia
Disease Models, Animal
Disease Progression
Female
Gene Ontology
Heterografts
Humans
Male
Mice
Mice, Inbred C57BL
Muscle, Skeletal
Neoplasm Transplantation
Pancreatic Neoplasms
Transcriptome
