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Medical College of Wisconsin

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Gustavo Leone PhD

Sr Associate Dean, Director, Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

Director of the Cancer Center
Member of the Center for Immunology

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Publications (180)

GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma. (Del Bufalo F, De Angelis B, Caruana I, Del Baldo G, De Ioris MA, Serra A, Mastronuzzi A, Cefalo MG, Pagliara D, Amicucci M, Li Pira G, Leone G, Bertaina V, Sinibaldi M, Di Cecca S, Guercio M, Abbaszadeh Z, Iaffaldano L, Gunetti M, Iacovelli S, Bugianesi R, Macchia S, Algeri M, Merli P, Galaverna F, Abbas R, Garganese MC, Villani MF, Colafati GS, Bonetti F, Rabusin M, Perruccio K, Folsi V, Quintarelli C, Locatelli F, Precision Medicine Team–IRCCS Ospedale Pediatrico Bambino Gesù) N Engl J Med 2023 Apr 06;388(14):1284-1295 PMID: 37018492 SCOPUS ID: 2-s2.0-85151776363 04/06/2023 111 Citations

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. (George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P) Cell Rep 2023 Mar 28;42(3):112228 PMID: 36884347 PMCID: PMC10233815 SCOPUS ID: 2-s2.0-85149682952 03/09/2023

Increasing Mononuclear Diploid Cardiomyocytes by Loss of E2F Transcription Factor 7/8 Fails to Improve Cardiac Regeneration After Infarct. (Yu Z, Zhang L, Cattaneo P, Guimarães-Camboa N, Fang X, Gu Y, Peterson KL, Bogomolovas J, Cuitino C, Leone GW, Chen J, Evans SM) Circulation 2023 Jan 10;147(2):183-186 PMID: 36622904 PMCID: PMC9988404 SCOPUS ID: 2-s2.0-85145688465 01/10/2023 3 Citations

The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis. (Han L, Wu Y, Fang K, Sweeney S, Roesner UK, Parrish M, Patel K, Walter T, Piermattei J, Trimboli A, Lefler J, Timmers CD, Yu XZ, Jin VX, Zimmermann MT, Mathison AJ, Urrutia R, Ostrowski MC, Leone G) Nat Commun 2023 Jan 03;14(1):1 PMID: 36596776 PMCID: PMC9810714 SCOPUS ID: 2-s2.0-85145429848 01/04/2023 16 Citations

The Rb/E2F axis is a key regulator of the molecular signatures instructing the quiescent and activated adult neural stem cell state. (Fong BC, Chakroun I, Iqbal MA, Paul S, Bastasic J, O'Neil D, Yakubovich E, Bejjani AT, Ahmadi N, Carter A, Clark A, Leone G, Park DS, Ghanem N, Vandenbosch R, Slack RS) Cell Rep 2022 Nov 01;41(5):111578 PMID: 36323247 SCOPUS ID: 2-s2.0-85140871739 11/03/2022 4 Citations

Discovery of nonautonomous modulators of activated Ras. (Corchado-Sonera M, Rambani K, Navarro K, Kladney R, Dowdle J, Leone G, Chamberlin HM) G3 (Bethesda) 2022 Sep 30;12(10) PMID: 35929788 PMCID: PMC9526067 SCOPUS ID: 2-s2.0-85139433642 08/06/2022 1 Citation

STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer. (Lefler JE, MarElia-Bennett CB, Thies KA, Hildreth BE 3rd, Sharma SM, Pitarresi JR, Han L, Everett C, Koivisto C, Cuitino MC, Timmers CD, O'Quinn E, Parrish M, Romeo MJ, Linke AJ, Hobbs GA, Leone G, Guttridge DC, Zimmers TA, Lesinski GB, Ostrowski MC) Life Sci Alliance 2022 Nov;5(11) PMID: 35803738 PMCID: PMC9270499 SCOPUS ID: 2-s2.0-85134426331 07/09/2022 17 Citations

Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner. (Wu J, Liu X, Reeser JAW, Trimboli AJ, Pécot T, Sizemore GM, Naidu SK, Fernandez SA, Yu L, Hallett M, Park M, Leone GW, Hildreth BE, Ostrowski MC) Mol Cancer Res 2022 Aug 05;20(8):1233-1246 PMID: 35533313 PMCID: PMC9357052 SCOPUS ID: 2-s2.0-85135596986 05/10/2022 5 Citations

Origin, activation and heterogeneity of fibroblasts associated with pancreas and breast cancers. (Han L, Seward C, Leone G, Ostrowski MC) Adv Cancer Res 2022;154:169-201 PMID: 35459469 SCOPUS ID: 2-s2.0-85127356799 04/24/2022

Imaging Mass Spectrometry Reveals Alterations in N-Linked Glycosylation That Are Associated With Histopathological Changes in Nonalcoholic Steatohepatitis in Mouse and Human. (Ochoa-Rios S, O'Connor IP, Kent LN, Clouse JM, Hadjiyannis Y, Koivisto C, Pecot T, Angel PM, Drake RR, Leone G, Mehta AS, Rockey DC) Mol Cell Proteomics 2022 May;21(5):100225 PMID: 35331917 PMCID: PMC9092512 SCOPUS ID: 2-s2.0-85130862256 03/26/2022 5 Citations

Deep learning tools and modeling to estimate the temporal expression of cell cycle proteins from 2D still images. (Pécot T, Cuitiño MC, Johnson RH, Timmers C, Leone G) PLoS Comput Biol 2022 Mar;18(3):e1009949 PMID: 35286300 PMCID: PMC8947602 SCOPUS ID: 2-s2.0-85126910772 03/15/2022 3 Citations

Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss. (Yoshida A, Phillips-Mason P, Tarallo V, Avril S, Koivisto C, Leone G, Diehl JA) Oncogene 2022 Apr;41(15):2187-2195 PMID: 35210557 PMCID: PMC10056880 SCOPUS ID: 2-s2.0-85125132416 02/26/2022 4 Citations

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. (George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P) Cell Rep 2021 Nov 02;37(5):109934 PMID: 34731628 PMCID: PMC8675433 SCOPUS ID: 2-s2.0-85118477211 11/04/2021 31 Citations

Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome. (Chu H, Sacharidou A, Nguyen A, Li C, Chambliss KL, Salmon JE, Shen YM, Lo J, Leone GW, Herz J, Hui DY, Marciano DK, Abrahams VM, Natale BV, Montalbano AP, Xiao X, Xu L, Natale DR, Shaul PW, Mineo C) Circ Res 2021 Sep 17;129(7):735-750 PMID: 34404233 PMCID: PMC8448973 SCOPUS ID: 2-s2.0-85115908382 08/19/2021 9 Citations

Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia. (Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H) J Clin Invest 2021 Aug 16;131(16) PMID: 34255748 PMCID: PMC8363288 SCOPUS ID: 2-s2.0-85113146308 07/14/2021 21 Citations

Evaluating the efficacy of enzalutamide and the development of resistance in a preclinical mouse model of type-I endometrial carcinoma (Koivisto CS, Parrish M, Bonala SB, Ngoi S, Torres A, Gallagher J, Sanchez-Hodge R, Zeinner V, Nahhas GJ, Liu B, Cohn DE, Backes FJ, Goodfellow PJ, Chamberlin HM, Leone G) Neoplasia (United States) October 2020;22(10):484-496 SCOPUS ID: 2-s2.0-85089427396 10/01/2020 6 Citations

Evaluating the efficacy of enzalutamide and the development of resistance in a preclinical mouse model of type-I endometrial carcinoma. (Koivisto CS, Parrish M, Bonala SB, Ngoi S, Torres A, Gallagher J, Sanchez-Hodge R, Zeinner V, Nahhas GJ, Liu B, Cohn DE, Backes FJ, Goodfellow PJ, Chamberlin HM, Leone G) Neoplasia 2020 Oct;22(10):484-496 PMID: 32818842 PMCID: PMC7452078 SCOPUS ID: 2-s2.0-85089427396 08/21/2020 6 Citations

Cyclin D-CDK4/6 functions in cancer. (Gao X, Leone GW, Wang H) Adv Cancer Res 2020;148:147-169 PMID: 32723562 SCOPUS ID: 2-s2.0-85082819252 07/30/2020 113 Citations

Stromal Platelet-Derived Growth Factor Receptor-β Signaling Promotes Breast Cancer Metastasis in the Brain. (Thies KA, Hammer AM, Hildreth BE 3rd, Steck SA, Spehar JM, Kladney RD, Geisler JA, Das M, Russell LO, Bey JF 4th, Bolyard CM, Pilarski R, Trimboli AJ, Cuitiño MC, Koivisto CS, Stover DG, Schoenfield L, Otero J, Godbout JP, Chakravarti A, Ringel MD, Ramaswamy B, Li Z, Kaur B, Leone G, Ostrowski MC, Sizemore ST, Sizemore GM) Cancer Res 2021 Feb 01;81(3):606-618 PMID: 32327406 PMCID: PMC7581545 SCOPUS ID: 2-s2.0-85100405678 04/25/2020 30 Citations

Capturing variations in nuclear phenotypes (Raman S, Singh S, Pécot T, Caserta E, Huang K, Rittscher J, Leone G, Machiraju R) Journal of Computational Science September 2019;36 SCOPUS ID: 2-s2.0-85071611725 09/01/2019

PTEN in the Stroma. (Thies KA, Lefler JE, Leone G, Ostrowski MC) Cold Spring Harb Perspect Med 2019 Oct 01;9(10) PMID: 31427286 PMCID: PMC6771362 SCOPUS ID: 2-s2.0-85072848926 08/21/2019 8 Citations

Modeling Human Cancer-induced Cachexia. (Talbert EE, Cuitiño MC, Ladner KJ, Rajasekerea PV, Siebert M, Shakya R, Leone GW, Ostrowski MC, Paleo B, Weisleder N, Reiser PJ, Webb A, Timmers CD, Eiferman DS, Evans DC, Dillhoff ME, Schmidt CR, Guttridge DC) Cell Rep 2019 Aug 06;28(6):1612-1622.e4 PMID: 31390573 PMCID: PMC6733019 SCOPUS ID: 2-s2.0-85069958981 08/08/2019 80 Citations

Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer. (Basree MM, Shinde N, Koivisto C, Cuitino M, Kladney R, Zhang J, Stephens J, Palettas M, Zhang A, Kim HK, Acero-Bedoya S, Trimboli A, Stover DG, Ludwig T, Ganju R, Weng D, Shields P, Freudenheim J, Leone GW, Sizemore GM, Majumder S, Ramaswamy B) Breast Cancer Res 2019 Jul 17;21(1):80 PMID: 31315645 PMCID: PMC6637535 SCOPUS ID: 2-s2.0-85070057466 07/19/2019 29 Citations

Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression. (Bowen C, Ostrowski MC, Leone G, Gelmann EP) Cancer Res 2019 Aug 15;79(16):4124-4134 PMID: 31213464 PMCID: PMC6753942 SCOPUS ID: 2-s2.0-85070602387 06/20/2019 24 Citations

Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation. (Cuitiño MC, Pécot T, Sun D, Kladney R, Okano-Uchida T, Shinde N, Saeed R, Perez-Castro AJ, Webb A, Liu T, Bae SI, Clijsters L, Selner N, Coppola V, Timmers C, Ostrowski MC, Pagano M, Leone G) Cell Rep 2019 Jun 18;27(12):3547-3560.e5 PMID: 31130414 PMCID: PMC6673649 SCOPUS ID: 2-s2.0-85067252067 05/28/2019 38 Citations

Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs. (Clijsters L, Hoencamp C, Calis JJA, Marzio A, Handgraaf SM, Cuitino MC, Rosenberg BR, Leone G, Pagano M) Mol Cell 2019 Jun 20;74(6):1264-1277.e7 PMID: 31130363 PMCID: PMC6588466 SCOPUS ID: 2-s2.0-85067232482 05/28/2019 64 Citations

The broken cycle: E2F dysfunction in cancer. (Kent LN, Leone G) Nat Rev Cancer 2019 Jun;19(6):326-338 PMID: 31053804 SCOPUS ID: 2-s2.0-85065291001 05/06/2019 437 Citations

Sex-specific regulation of stress-induced fetal glucocorticoid surge by the mouse placenta. (Wieczorek A, Perani CV, Nixon M, Constancia M, Sandovici I, Zazara DE, Leone G, Zhang MZ, Arck PC, Solano ME) Am J Physiol Endocrinol Metab 2019 Jul 01;317(1):E109-E120 PMID: 30990748 SCOPUS ID: 2-s2.0-85068546357 04/17/2019 37 Citations

Periostin/β1integrin interaction regulates p21-activated kinases in valvular interstitial cell survival and in actin cytoskeleton reorganization. (Ghatak S, Misra S, Moreno-Rodrigue RA, Hascall VC, Leone GW, Markwald RR) Biochim Biophys Acta Gen Subj 2019 May;1863(5):813-829 PMID: 30742951 SCOPUS ID: 2-s2.0-85061665625 02/12/2019 9 Citations

Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth. (Pitarresi JR, Liu X, Avendano A, Thies KA, Sizemore GM, Hammer AM, Hildreth BE 3rd, Wang DJ, Steck SA, Donohue S, Cuitiño MC, Kladney RD, Mace TA, Chang JJ, Ennis CS, Li H, Reeves RH, Blackshaw S, Zhang J, Yu L, Fernandez SA, Frankel WL, Bloomston M, Rosol TJ, Lesinski GB, Konieczny SF, Guttridge DC, Rustgi AK, Leone G, Song JW, Wu J, Ostrowski MC) Life Sci Alliance 2018 Oct;1(5):e201800190 PMID: 30456390 PMCID: PMC6238420 SCOPUS ID: 2-s2.0-85057034002 11/21/2018 28 Citations

Stromal PTEN determines mammary epithelial response to radiotherapy. (Sizemore GM, Balakrishnan S, Thies KA, Hammer AM, Sizemore ST, Trimboli AJ, Cuitiño MC, Steck SA, Tozbikian G, Kladney RD, Shinde N, Das M, Park D, Majumder S, Krishnan S, Yu L, Fernandez SA, Chakravarti A, Shields PG, White JR, Yee LD, Rosol TJ, Ludwig T, Park M, Leone G, Ostrowski MC) Nat Commun 2018 Jul 17;9(1):2783 PMID: 30018330 PMCID: PMC6050339 SCOPUS ID: 2-s2.0-85050372792 07/19/2018 18 Citations

Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. (Hsu AH, Lum MA, Shim KS, Frederick PJ, Morrison CD, Chen B, Lele SM, Sheinin YM, Daikoku T, Dey SK, Leone G, Black AR, Black JD) Cell Rep 2018 Jul 17;24(3):655-669 PMID: 30021163 PMCID: PMC6118133 SCOPUS ID: 2-s2.0-85049825453 07/19/2018 32 Citations

Endoreduplication of the mouse genome in the absence of ORC1. (Okano-Uchida T, Kent LN, Ouseph MM, McCarty B, Frank JJ, Kladney R, Cuitino MC, Thompson JC, Coppola V, Asano M, Leone G) Genes Dev 2018 Jul 01;32(13-14):978-990 PMID: 29967292 PMCID: PMC6075035 SCOPUS ID: 2-s2.0-85049506966 07/04/2018 17 Citations

Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation. (Ahirwar DK, Nasser MW, Ouseph MM, Elbaz M, Cuitiño MC, Kladney RD, Varikuti S, Kaul K, Satoskar AR, Ramaswamy B, Zhang X, Ostrowski MC, Leone G, Ganju RK) Oncogene 2018 Aug;37(32):4428-4442 PMID: 29720724 PMCID: PMC7063845 SCOPUS ID: 2-s2.0-85046376807 05/04/2018 88 Citations

annoPeak: a web application to annotate and visualize peaks from ChIP-seq/ChIP-exo-seq. (Tang X, Srivastava A, Liu H, Machiraju R, Huang K, Leone G) Bioinformatics 2018 Aug 15;34(16):2879 PMID: 29672705 PMCID: PMC6084593 SCOPUS ID: 2-s2.0-85065307555 04/20/2018

A hedgehog pathway-dependent gene signature is associated with poor clinical outcomes in Luminal A breast cancer. (Rudolph M, Sizemore ST, Lu Y, Teng KY, Basree MM, Reinbolt R, Timmers CD, Leone G, Ostrowski MC, Majumder S, Ramaswamy B) Breast Cancer Res Treat 2018 Jun;169(3):457-467 PMID: 29464534 SCOPUS ID: 2-s2.0-85042237246 02/22/2018 8 Citations

hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival. (Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A, Abraham SA, Hair A, Helgason GV, Aspinall-O'Dea M, Bhatia R, Leone G, Kranc KR, Whetton AD, Holyoake TL) Blood 2018 Apr 05;131(14):1532-1544 PMID: 29437554 PMCID: PMC6027092 SCOPUS ID: 2-s2.0-85047638589 02/14/2018 35 Citations

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway. (Ollila S, Domènech-Moreno E, Laajanen K, Wong IP, Tripathi S, Pentinmikko N, Gao Y, Yan Y, Niemelä EH, Wang TC, Viollet B, Leone G, Katajisto P, Vaahtomeri K, Mäkelä TP) J Clin Invest 2018 Jan 02;128(1):402-414 PMID: 29202476 PMCID: PMC5749537 SCOPUS ID: 2-s2.0-85040186854 12/05/2017 50 Citations

Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1. (Sizemore GM, Balakrishnan S, Hammer AM, Thies KA, Trimboli AJ, Wallace JA, Sizemore ST, Kladney RD, Woelke SA, Yu L, Fernandez SA, Chakravarti A, Leone G, Ostrowski MC) Oncogene 2017 Nov 23;36(47):6658 PMID: 29035387 SCOPUS ID: 2-s2.0-85034961349 10/17/2017 3 Citations

Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele. (Wu J, Liu X, Nayak SG, Pitarresi JR, Cuitiño MC, Yu L, Hildreth BE 3rd, Thies KA, Schilling DJ, Fernandez SA, Leone G, Ostrowski MC) PLoS One 2017;12(9):e0184984 PMID: 28934293 PMCID: PMC5608307 SCOPUS ID: 2-s2.0-85029768561 09/22/2017 14 Citations

NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development. (Ratnam NM, Peterson JM, Talbert EE, Ladner KJ, Rajasekera PV, Schmidt CR, Dillhoff ME, Swanson BJ, Haverick E, Kladney RD, Williams TM, Leone GW, Wang DJ, Guttridge DC) J Clin Invest 2017 Oct 02;127(10):3796-3809 PMID: 28891811 PMCID: PMC5617672 SCOPUS ID: 2-s2.0-85030548987 09/12/2017 113 Citations

IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-κB. (Victor AR, Nalin AP, Dong W, McClory S, Wei M, Mao C, Kladney RD, Youssef Y, Chan WK, Briercheck EL, Hughes T, Scoville SD, Pitarresi JR, Chen C, Manz S, Wu LC, Zhang J, Ostrowski MC, Freud AG, Leone GW, Caligiuri MA, Yu J) J Immunol 2017 Oct 01;199(7):2333-2342 PMID: 28842466 PMCID: PMC5624342 SCOPUS ID: 2-s2.0-85029725092 08/27/2017 68 Citations

Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression. (Casadei L, Calore F, Creighton CJ, Guescini M, Batte K, Iwenofu OH, Zewdu A, Braggio DA, Bill KL, Fadda P, Lovat F, Lopez G, Gasparini P, Chen JL, Kladney RD, Leone G, Lev D, Croce CM, Pollock RE) Cancer Res 2017 Jul 15;77(14):3846-3856 PMID: 28588009 PMCID: PMC6033276 SCOPUS ID: 2-s2.0-85023780338 06/08/2017 144 Citations

Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. (Liu H, Dowdle JA, Khurshid S, Sullivan NJ, Bertos N, Rambani K, Mair M, Daniel P, Wheeler E, Tang X, Toth K, Lause M, Harrigan ME, Eiring K, Sullivan C, Sullivan MJ, Chang SW, Srivastava S, Conway JS, Kladney R, McElroy J, Bae S, Lu Y, Tofigh A, Saleh SMI, Fernandez SA, Parvin JD, Coppola V, Macrae ER, Majumder S, Shapiro CL, Yee LD, Ramaswamy B, Hallett M, Ostrowski MC, Park M, Chamberlin HM, Leone G) Dev Cell 2017 May 22;41(4):392-407.e6 PMID: 28535374 PMCID: PMC5508591 SCOPUS ID: 2-s2.0-85019599277 05/24/2017 23 Citations

Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth. (Hammer AM, Sizemore GM, Shukla VC, Avendano A, Sizemore ST, Chang JJ, Kladney RD, Cuitiño MC, Thies KA, Verfurth Q, Chakravarti A, Yee LD, Leone G, Song JW, Ghadiali SN, Ostrowski MC) Neoplasia 2017 Jun;19(6):496-508 PMID: 28501760 PMCID: PMC5440288 SCOPUS ID: 2-s2.0-85019674007 05/16/2017 43 Citations

annoPeak: a web application to annotate and visualize peaks from ChIP-seq/ChIP-exo-seq. (Tang X, Srivastava A, Liu H, Machiraju R, Huang K, Leone G) Bioinformatics 2017 May 15;33(10):1570-1571 PMID: 28169395 PMCID: PMC5860050 SCOPUS ID: 2-s2.0-85020271799 02/09/2017 5 Citations

Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma. (Kent LN, Bae S, Tsai SY, Tang X, Srivastava A, Koivisto C, Martin CK, Ridolfi E, Miller GC, Zorko SM, Plevris E, Hadjiyannis Y, Perez M, Nolan E, Kladney R, Westendorp B, de Bruin A, Fernandez S, Rosol TJ, Pohar KS, Pipas JM, Leone G) J Clin Invest 2017 Mar 01;127(3):830-842 PMID: 28134624 PMCID: PMC5330731 SCOPUS ID: 2-s2.0-85015832720 01/31/2017 81 Citations

Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1. (Sizemore GM, Balakrishnan S, Hammer AM, Thies KA, Trimboli AJ, Wallace JA, Sizemore ST, Kladney RD, Woelke SA, Yu L, Fernandez SA, Chakravarti A, Leone G, Ostrowski MC) Oncogene 2017 Apr 20;36(16):2297-2308 PMID: 27797378 PMCID: PMC5398932 SCOPUS ID: 2-s2.0-84992697172 11/01/2016 20 Citations

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia. (Pitarresi JR, Liu X, Sharma SM, Cuitiño MC, Kladney RD, Mace TA, Donohue S, Nayak SG, Qu C, Lee J, Woelke SA, Trela S, LaPak K, Yu L, McElroy J, Rosol TJ, Shakya R, Ludwig T, Lesinski GB, Fernandez SA, Konieczny SF, Leone G, Wu J, Ostrowski MC) Neoplasia 2016 Sep;18(9):541-52 PMID: 27659014 PMCID: PMC5031867 SCOPUS ID: 2-s2.0-84992420700 09/24/2016 26 Citations

Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. (Liu X, Pitarresi JR, Cuitiño MC, Kladney RD, Woelke SA, Sizemore GM, Nayak SG, Egriboz O, Schweickert PG, Yu L, Trela S, Schilling DJ, Halloran SK, Li M, Dutta S, Fernandez SA, Rosol TJ, Lesinski GB, Shakya R, Ludwig T, Konieczny SF, Leone G, Wu J, Ostrowski MC) Genes Dev 2016 Sep 01;30(17):1943-55 PMID: 27633013 PMCID: PMC5066238 SCOPUS ID: 2-s2.0-84988842034 09/17/2016 46 Citations

RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation. (Jones RA, Robinson TJ, Liu JC, Shrestha M, Voisin V, Ju Y, Chung PE, Pellecchia G, Fell VL, Bae S, Muthuswamy L, Datti A, Egan SE, Jiang Z, Leone G, Bader GD, Schimmer A, Zacksenhaus E) J Clin Invest 2016 Oct 03;126(10):3739-3757 PMID: 27571409 PMCID: PMC5096803 SCOPUS ID: 2-s2.0-84991702445 08/30/2016 100 Citations

E2f8 mediates tumor suppression in postnatal liver development. (Kent LN, Rakijas JB, Pandit SK, Westendorp B, Chen HZ, Huntington JT, Tang X, Bae S, Srivastava A, Senapati S, Koivisto C, Martin CK, Cuitino MC, Perez M, Clouse JM, Chokshi V, Shinde N, Kladney R, Sun D, Perez-Castro A, Matondo RB, Nantasanti S, Mokry M, Huang K, Machiraju R, Fernandez S, Rosol TJ, Coppola V, Pohar KS, Pipas JM, Schmidt CR, de Bruin A, Leone G) J Clin Invest 2016 Aug 01;126(8):2955-69 PMID: 27454291 PMCID: PMC4966321 SCOPUS ID: 2-s2.0-84987814871 07/28/2016 67 Citations

Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer. (Thurlings I, Martínez-López LM, Westendorp B, Zijp M, Kuiper R, Tooten P, Kent LN, Leone G, Vos HJ, Burgering B, de Bruin A) Oncogene 2017 Feb 09;36(6):829-839 PMID: 27452520 PMCID: PMC5311251 SCOPUS ID: 2-s2.0-84979623343 07/28/2016 43 Citations

Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice. (Tang X, Liu H, Srivastava A, Pécot T, Chen Z, Wang Q, Huang K, Sáenz-Robles MT, Cantalupo P, Pipas J, Leone G) Sci Data 2016 Feb 16;3:160008 PMID: 26881867 PMCID: PMC4755127 SCOPUS ID: 2-s2.0-84960968749 02/18/2016 5 Citations

FGFR and PTEN signaling interact during lens development to regulate cell survival. (Chaffee BR, Hoang TV, Leonard MR, Bruney DG, Wagner BD, Dowd JR, Leone G, Ostrowski MC, Robinson ML) Dev Biol 2016 Feb 15;410(2):150-163 PMID: 26764128 PMCID: PMC4767529 SCOPUS ID: 2-s2.0-84957852055 01/15/2016 20 Citations

The Spectrum of E2F in Liver Disease--Mediated Regulation in Biology and Cancer. (Huntington JT, Tang X, Kent LN, Schmidt CR, Leone G) J Cell Physiol 2016 Jul;231(7):1438-49 PMID: 26566968 SCOPUS ID: 2-s2.0-84962564510 11/15/2015 10 Citations

E2f3 in tumor macrophages promotes lung metastasis. (Trikha P, Sharma N, Pena C, Reyes A, Pécot T, Khurshid S, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Ostrowski MC, Leone G) Oncogene 2016 Jul 14;35(28):3636-46 PMID: 26549026 PMCID: PMC4861698 SCOPUS ID: 2-s2.0-84978878229 11/10/2015 46 Citations

WWP2 and its association with PTEN in endometrial cancer. (Clements AE, Bravo V, Koivisto C, Cohn DE, Leone G) Gynecol Oncol Rep 2015 Aug;13:26-9 PMID: 26425715 PMCID: PMC4563582 SCOPUS ID: 2-s2.0-84964815261 10/02/2015 19 Citations

Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo. (Caserta E, Egriboz O, Wang H, Martin C, Koivisto C, Pecót T, Kladney RD, Shen C, Shim KS, Pham T, Karikomi MK, Mauntel MJ, Majumder S, Cuitino MC, Tang X, Srivastava A, Yu L, Wallace J, Mo X, Park M, Fernandez SA, Pilarski R, La Perle KM, Rosol TJ, Coppola V, Castrillon DH, Timmers C, Cohn DE, O'Malley DM, Backes F, Suarez AA, Goodfellow P, Chamberlin HM, Macrae ER, Shapiro CL, Ostrowski MC, Leone G) Genes Dev 2015 Aug 15;29(16):1707-20 PMID: 26302789 PMCID: PMC4561480 SCOPUS ID: 2-s2.0-84940092969 08/26/2015 26 Citations

Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. (Liu H, Tang X, Srivastava A, Pécot T, Daniel P, Hemmelgarn B, Reyes S, Fackler N, Bajwa A, Kladney R, Koivisto C, Chen Z, Wang Q, Huang K, Machiraju R, Sáenz-Robles MT, Cantalupo P, Pipas JM, Leone G) Nat Cell Biol 2015 Aug;17(8):1036-48 PMID: 26192440 PMCID: PMC4526313 SCOPUS ID: 2-s2.0-84938694015 07/21/2015 56 Citations

Tissue-specific targeting of cell fate regulatory genes by E2f factors. (Julian LM, Liu Y, Pakenham CA, Dugal-Tessier D, Ruzhynsky V, Bae S, Tsai SY, Leone G, Slack RS, Blais A) Cell Death Differ 2016 Apr;23(4):565-75 PMID: 25909886 PMCID: PMC4986644 SCOPUS ID: 2-s2.0-84960796855 04/25/2015 24 Citations

PTEN is a negative regulator of NK cell cytolytic function. (Briercheck EL, Trotta R, Chen L, Hartlage AS, Cole JP, Cole TD, Mao C, Banerjee PP, Hsu HT, Mace EM, Ciarlariello D, Mundy-Bosse BL, Garcia-Cao I, Scoville SD, Yu L, Pilarski R, Carson WE 3rd, Leone G, Pandolfi PP, Yu J, Orange JS, Caligiuri MA) J Immunol 2015 Feb 15;194(4):1832-40 PMID: 25595786 PMCID: PMC4319309 SCOPUS ID: 2-s2.0-84922569775 01/18/2015 34 Citations

CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth. (Mathsyaraja H, Thies K, Taffany DA, Deighan C, Liu T, Yu L, Fernandez SA, Shapiro C, Otero J, Timmers C, Lustberg MB, Chalmers J, Leone G, Ostrowski MC) Oncogene 2015 Jul;34(28):3651-61 PMID: 25241894 PMCID: PMC4369473 SCOPUS ID: 2-s2.0-84954027952 09/23/2014 54 Citations

Viral oncogene expression in the stem/progenitor cell compartment of the mouse intestine induces adenomatous polyps. (Sáenz Robles MT, Chong JL, Koivisto C, Trimboli A, Liu H, Leone G, Pipas JM) Mol Cancer Res 2014 Oct;12(10):1355-64 PMID: 24994749 PMCID: PMC4201981 SCOPUS ID: 2-s2.0-84907994320 07/06/2014 3 Citations

Cited2 is required in trophoblasts for correct placental capillary patterning. (Moreau JL, Artap ST, Shi H, Chapman G, Leone G, Sparrow DB, Dunwoodie SL) Dev Biol 2014 Aug 01;392(1):62-79 PMID: 24803182 SCOPUS ID: 2-s2.0-84901920145 05/08/2014 34 Citations

A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice. (Cecchini MJ, Thwaites MJ, Talluri S, MacDonald JI, Passos DT, Chong JL, Cantalupo P, Stafford PM, Sáenz-Robles MT, Francis SM, Pipas JM, Leone G, Welch I, Dick FA) Mol Cell Biol 2014 Jun;34(11):2029-45 PMID: 24662053 PMCID: PMC4019062 SCOPUS ID: 2-s2.0-84899888987 03/26/2014 25 Citations

HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. (Rath KS, Naidu SK, Lata P, Bid HK, Rivera BK, McCann GA, Tierney BJ, Elnaggar AC, Bravo V, Leone G, Houghton P, Hideg K, Kuppusamy P, Cohn DE, Selvendiran K) Cancer Res 2014 Apr 15;74(8):2316-27 PMID: 24590057 PMCID: PMC4286190 SCOPUS ID: 2-s2.0-84899557646 03/05/2014 67 Citations

QChIPat: a quantitative method to identify distinct binding patterns for two biological ChIP-seq samples in different experimental conditions. (Liu B, Yi J, Sv A, Lan X, Ma Y, Huang TH, Leone G, Jin VX) BMC Genomics 2013;14 Suppl 8(Suppl 8):S3 PMID: 24564479 PMCID: PMC4042236 SCOPUS ID: 2-s2.0-84889687271 02/26/2014 26 Citations

Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. (Schmidt JW, Wehde BL, Sakamoto K, Triplett AA, Anderson SM, Tsichlis PN, Leone G, Wagner KU) Mol Cell Biol 2014 Apr;34(7):1363-77 PMID: 24469394 PMCID: PMC3993568 SCOPUS ID: 2-s2.0-84895779092 01/29/2014 55 Citations

Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis. (Wu L, de Bruin A, Wang H, Simmons T, Cleghorn W, Goldenberg LE, Sites E, Sandy A, Trimboli A, Fernandez SA, Eng C, Shapiro C, Leone G) Oncogene 2015 Jan 02;34(1):119-28 PMID: 24276244 PMCID: PMC4032808 SCOPUS ID: 2-s2.0-84964314758 11/28/2013 27 Citations

Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells. (Julian LM, Vandenbosch R, Pakenham CA, Andrusiak MG, Nguyen AP, McClellan KA, Svoboda DS, Lagace DC, Park DS, Leone G, Blais A, Slack RS) Cell Stem Cell 2013 Apr 04;12(4):440-52 PMID: 23499385 SCOPUS ID: 2-s2.0-84875948123 03/19/2013 63 Citations

Endoscopic treatment of ganglioneuroma of the colon associated with a lipoma: a case report. (Fiori E, Pozzessere C, Lamazza A, Leone G, Borrini F, Schillaci A, Mingazzini P) J Med Case Rep 2012 Sep 14;6:304 PMID: 22978818 PMCID: PMC3469395 SCOPUS ID: 2-s2.0-84866179377 09/18/2012 13 Citations

E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. (Weijts BG, Bakker WJ, Cornelissen PW, Liang KH, Schaftenaar FH, Westendorp B, de Wolf CA, Paciejewska M, Scheele CL, Kent L, Leone G, Schulte-Merker S, de Bruin A) EMBO J 2012 Oct 03;31(19):3871-84 PMID: 22903062 PMCID: PMC3463843 SCOPUS ID: 2-s2.0-84867053431 08/21/2012 99 Citations

Non parametric cell nuclei segmentation based on a tracking over depth from 3D fluorescence confocal images (Pecot T, Singh S, Caserta E, Huang K, MacHiraju R, Leone G) Proceedings - International Symposium on Biomedical Imaging 2012:170-173 SCOPUS ID: 2-s2.0-84864861879 08/15/2012 9 Citations

Loss of fibroblast HIF-1α accelerates tumorigenesis. (Kim JW, Evans C, Weidemann A, Takeda N, Lee YS, Stockmann C, Branco-Price C, Brandberg F, Leone G, Ostrowski MC, Johnson RS) Cancer Res 2012 Jul 01;72(13):3187-95 PMID: 22556263 PMCID: PMC4089958 SCOPUS ID: 2-s2.0-84863606091 05/05/2012 55 Citations

E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-Dependent negative feedback loop (Timmers C, Sharma N, Opavsky R, Maiti B, Wu L, Wu J, Orringer D, Trikha P, Saavedra HI, Leone G) Molecular and Cellular Biology May 2012;32(9):1758 SCOPUS ID: 2-s2.0-84861401660 05/01/2012

Atypical E2F repressors and activators coordinate placental development. (Ouseph MM, Li J, Chen HZ, Pécot T, Wenzel P, Thompson JC, Comstock G, Chokshi V, Byrne M, Forde B, Chong JL, Huang K, Machiraju R, de Bruin A, Leone G) Dev Cell 2012 Apr 17;22(4):849-62 PMID: 22516201 PMCID: PMC3483796 SCOPUS ID: 2-s2.0-84859872654 04/21/2012 76 Citations

Evidence for a stepwise program of extrathymic T cell development within the human tonsil. (McClory S, Hughes T, Freud AG, Briercheck EL, Martin C, Trimboli AJ, Yu J, Zhang X, Leone G, Nuovo G, Caligiuri MA) J Clin Invest 2012 Apr;122(4):1403-15 PMID: 22378041 PMCID: PMC3314444 SCOPUS ID: 2-s2.0-84858793590 03/02/2012 71 Citations

Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. (Bronisz A, Godlewski J, Wallace JA, Merchant AS, Nowicki MO, Mathsyaraja H, Srinivasan R, Trimboli AJ, Martin CK, Li F, Yu L, Fernandez SA, Pécot T, Rosol TJ, Cory S, Hallett M, Park M, Piper MG, Marsh CB, Yee LD, Jimenez RE, Nuovo G, Lawler SE, Chiocca EA, Leone G, Ostrowski MC) Nat Cell Biol 2011 Dec 18;14(2):159-67 PMID: 22179046 PMCID: PMC3271169 SCOPUS ID: 2-s2.0-84856464305 12/20/2011 245 Citations

S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways. (Nasser MW, Qamri Z, Deol YS, Ravi J, Powell CA, Trikha P, Schwendener RA, Bai XF, Shilo K, Zou X, Leone G, Wolf R, Yuspa SH, Ganju RK) Cancer Res 2012 Feb 01;72(3):604-15 PMID: 22158945 PMCID: PMC3271140 SCOPUS ID: 2-s2.0-84856527732 12/14/2011 97 Citations

The retinoblastoma tumor suppressor regulates a xenobiotic detoxification pathway. (Sáenz Robles MT, Case A, Chong JL, Leone G, Pipas JM) PLoS One 2011;6(10):e26019 PMID: 22022495 PMCID: PMC3192141 SCOPUS ID: 2-s2.0-80053943695 10/25/2011 5 Citations

Non-parametric population analysis of cellular phenotypes. (Singh S, Janoos F, Pécot T, Caserta E, Huang K, Rittscher J, Leone G, Machiraju R) Med Image Comput Comput Assist Interv 2011;14(Pt 2):343-51 PMID: 21995047 PMCID: PMC4295822 SCOPUS ID: 2-s2.0-82255164880 10/15/2011 9 Citations

Identifying nuclear phenotypes using semi-supervised metric learning. (Singh S, Janoos F, Pécot T, Caserta E, Leone G, Rittscher J, Machiraju R) Inf Process Med Imaging 2011;22:398-410 PMID: 21761673 PMCID: PMC4285701 SCOPUS ID: 2-s2.0-80052310717 07/19/2011 12 Citations

Pten in the breast tumor microenvironment: modeling tumor-stroma coevolution. (Wallace JA, Li F, Leone G, Ostrowski MC) Cancer Res 2011 Feb 15;71(4):1203-7 PMID: 21303970 PMCID: PMC3075554 SCOPUS ID: 2-s2.0-79951847466 02/10/2011 38 Citations

Cell proliferation in the absence of E2F1-3. (Wenzel PL, Chong JL, Sáenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, Robinson ML, Leone G) Dev Biol 2011 Mar 01;351(1):35-45 PMID: 21185283 PMCID: PMC3868453 SCOPUS ID: 2-s2.0-79551681885 12/28/2010 56 Citations

E2f1-3 are critical for myeloid development. (Trikha P, Sharma N, Opavsky R, Reyes A, Pena C, Ostrowski MC, Roussel MF, Leone G) J Biol Chem 2011 Feb 11;286(6):4783-95 PMID: 21115501 PMCID: PMC3039366 SCOPUS ID: 2-s2.0-79953010469 12/01/2010 29 Citations

Analysis of spatial variation of nuclear morphology in tissue microenvironments (Singh S, Raman S, Caserta E, Leone G, Ostrowski M, Rittscher J, Machiraju R) 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings 2010:1293-1296 SCOPUS ID: 2-s2.0-77955198635 08/09/2010 2 Citations

The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2. (Zeng X, Shaikh FY, Harrison MK, Adon AM, Trimboli AJ, Carroll KA, Sharma N, Timmers C, Chodosh LA, Leone G, Saavedra HI) Oncogene 2010 Sep 09;29(36):5103-12 PMID: 20581865 PMCID: PMC2972189 SCOPUS ID: 2-s2.0-77956627154 06/29/2010 71 Citations

Allele-specific tumor spectrum in pten knockin mice. (Wang H, Karikomi M, Naidu S, Rajmohan R, Caserta E, Chen HZ, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Weinstein M, Wang D, Sadee W, La Perle K, Stromberg P, Rosol TJ, Eng C, Ostrowski MC, Leone G) Proc Natl Acad Sci U S A 2010 Mar 16;107(11):5142-7 PMID: 20194734 PMCID: PMC2841921 SCOPUS ID: 2-s2.0-77950419842 03/03/2010 57 Citations

An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. (Zabuawala T, Taffany DA, Sharma SM, Merchant A, Adair B, Srinivasan R, Rosol TJ, Fernandez S, Huang K, Leone G, Ostrowski MC) Cancer Res 2010 Feb 15;70(4):1323-33 PMID: 20145133 PMCID: PMC2822898 SCOPUS ID: 2-s2.0-76749096776 02/11/2010 103 Citations

E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. (Chong JL, Wenzel PL, Sáenz-Robles MT, Nair V, Ferrey A, Hagan JP, Gomez YM, Sharma N, Chen HZ, Ouseph M, Wang SH, Trikha P, Culp B, Mezache L, Winton DJ, Sansom OJ, Chen D, Bremner R, Cantalupo PG, Robinson ML, Pipas JM, Leone G) Nature 2009 Dec 17;462(7275):930-4 PMID: 20016602 PMCID: PMC2806193 SCOPUS ID: 2-s2.0-72449177341 12/18/2009 197 Citations

Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis. (Srinivasan R, Zabuawala T, Huang H, Zhang J, Gulati P, Fernandez S, Karlo JC, Landreth GE, Leone G, Ostrowski MC) PLoS One 2009 Dec 14;4(12):e8283 PMID: 20011539 PMCID: PMC2789384 SCOPUS ID: 2-s2.0-77949518475 12/17/2009 135 Citations

E2F3 is a mediator of DNA damage-induced apoptosis. (Martinez LA, Goluszko E, Chen HZ, Leone G, Post S, Lozano G, Chen Z, Chauchereau A) Mol Cell Biol 2010 Jan;30(2):524-36 PMID: 19917728 PMCID: PMC2798461 SCOPUS ID: 2-s2.0-73549095168 11/18/2009 65 Citations

Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer. (Qamri Z, Preet A, Nasser MW, Bass CE, Leone G, Barsky SH, Ganju RK) Mol Cancer Ther 2009 Nov;8(11):3117-29 PMID: 19887554 PMCID: PMC4128286 SCOPUS ID: 2-s2.0-70949091684 11/06/2009 193 Citations

Emerging roles of E2Fs in cancer: an exit from cell cycle control. (Chen HZ, Tsai SY, Leone G) Nat Rev Cancer 2009 Nov;9(11):785-97 PMID: 19851314 PMCID: PMC3616489 SCOPUS ID: 2-s2.0-70350518233 10/24/2009 783 Citations

Pten in stromal fibroblasts suppresses mammary epithelial tumours. (Trimboli AJ, Cantemir-Stone CZ, Li F, Wallace JA, Merchant A, Creasap N, Thompson JC, Caserta E, Wang H, Chong JL, Naidu S, Wei G, Sharma SM, Stephens JA, Fernandez SA, Gurcan MN, Weinstein MB, Barsky SH, Yee L, Rosol TJ, Stromberg PC, Robinson ML, Pepin F, Hallett M, Park M, Ostrowski MC, Leone G) Nature 2009 Oct 22;461(7267):1084-91 PMID: 19847259 PMCID: PMC2767301 SCOPUS ID: 2-s2.0-70350510924 10/23/2009 441 Citations

Response (Eng C, Leone G, Orloff MS, Ostrowski MC) Cancer Research 1 September 2009;69(17):6769 SCOPUS ID: 2-s2.0-70149095243 09/01/2009

Genomic alterations in tumor stroma. (Eng C, Leone G, Orloff MS, Ostrowski MC) Cancer Res 2009 Sep 01;69(17):6759-64 PMID: 19706759 SCOPUS ID: 2-s2.0-70149117506 08/27/2009 45 Citations

Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. (Wei G, Srinivasan R, Cantemir-Stone CZ, Sharma SM, Santhanam R, Weinstein M, Muthusamy N, Man AK, Oshima RG, Leone G, Ostrowski MC) Blood 2009 Jul 30;114(5):1123-30 PMID: 19411629 PMCID: PMC2721789 SCOPUS ID: 2-s2.0-70349260738 05/05/2009 134 Citations

Atypical E2Fs: new players in the E2F transcription factor family. (Lammens T, Li J, Leone G, De Veylder L) Trends Cell Biol 2009 Mar;19(3):111-8 PMID: 19201609 PMCID: PMC2808192 SCOPUS ID: 2-s2.0-61749085629 02/10/2009 177 Citations

E2f3a and E2f3b contribute to the control of cell proliferation and mouse development. (Chong JL, Tsai SY, Sharma N, Opavsky R, Price R, Wu L, Fernandez SA, Leone G) Mol Cell Biol 2009 Jan;29(2):414-24 PMID: 19015245 PMCID: PMC2612501 SCOPUS ID: 2-s2.0-58249105141 11/19/2008 68 Citations

e-Science, caGrid, and Translational Biomedical Research. (Saltz J, Kurc T, Hastings S, Langella S, Oster S, Ervin D, Sharma A, Pan T, Gurcan M, Permar J, Ferreira R, Payne P, Catalyurek U, Caserta E, Leone G, Ostrowski MC, Madduri R, Foster I, Madhavan S, Buetow KH, Shanbhag K, Siegel E) Computer (Long Beach Calif) 2008 Nov;41(11):58-66 PMID: 21311723 PMCID: PMC3035203 SCOPUS ID: 2-s2.0-56649098899 11/01/2008 12 Citations

Tensor classification of N-point correlation function features for histology tissue segmentation. (Mosaliganti K, Janoos F, Irfanoglu O, Ridgway R, Machiraju R, Huang K, Saltz J, Leone G, Ostrowski M) Med Image Anal 2009 Feb;13(1):156-66 PMID: 18762444 PMCID: PMC4664199 SCOPUS ID: 2-s2.0-57049187101 09/03/2008 19 Citations

Mouse development with a single E2F activator. (Tsai SY, Opavsky R, Sharma N, Wu L, Naidu S, Nolan E, Feria-Arias E, Timmers C, Opavska J, de Bruin A, Chong JL, Trikha P, Fernandez SA, Stromberg P, Rosol TJ, Leone G) Nature 2008 Aug 28;454(7208):1137-41 PMID: 18594513 PMCID: PMC4288824 SCOPUS ID: 2-s2.0-50649086353 07/03/2008 81 Citations

An imaging workflow for characterizing phenotypical change in large histological mouse model datasets. (Mosaliganti K, Pan T, Ridgway R, Sharp R, Cooper L, Gulacy A, Sharma A, Irfanoglu O, Machiraju R, Kurc T, de Bruin A, Wenzel P, Leone G, Saltz J, Huang K) J Biomed Inform 2008 Dec;41(6):863-73 PMID: 18502696 PMCID: PMC2657595 SCOPUS ID: 2-s2.0-55749113489 05/27/2008 10 Citations

Reconstruction of cellular biological structures from optical microscopy data. (Mosaliganti K, Cooper L, Sharp R, Machiraju R, Leone G, Huang K, Saltz J) IEEE Trans Vis Comput Graph 2008;14(4):863-76 PMID: 18467760 SCOPUS ID: 2-s2.0-44649148372 05/10/2008 30 Citations

Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition. (Nadella KS, Jones GN, Trimboli A, Stratakis CA, Leone G, Kirschner LS) Cancer Res 2008 Apr 15;68(8):2671-7 PMID: 18413734 PMCID: PMC3129546 SCOPUS ID: 2-s2.0-42349115928 04/17/2008 32 Citations

Direct evidence for epithelial-mesenchymal transitions in breast cancer. (Trimboli AJ, Fukino K, de Bruin A, Wei G, Shen L, Tanner SM, Creasap N, Rosol TJ, Robinson ML, Eng C, Ostrowski MC, Leone G) Cancer Res 2008 Feb 01;68(3):937-45 PMID: 18245497 SCOPUS ID: 2-s2.0-38849093994 02/05/2008 318 Citations

Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. (Li J, Ran C, Li E, Gordon F, Comstock G, Siddiqui H, Cleghorn W, Chen HZ, Kornacker K, Liu CG, Pandit SK, Khanizadeh M, Weinstein M, Leone G, de Bruin A) Dev Cell 2008 Jan;14(1):62-75 PMID: 18194653 PMCID: PMC2253677 SCOPUS ID: 2-s2.0-37749005850 01/16/2008 173 Citations

Geometry-driven visualization of microscopic structures in biology (Mosaliganti K, MacHiraju R, Huang K, Leone G) Computer Graphics Forum May 2008;27(3):871-878 SCOPUS ID: 2-s2.0-53149141035 01/01/2008

Multi-resolution image segmentation using the 2-point correlation functions (Janoos F, Irfanoglu MO, Mosaliganti K, Machiraju R, Huang K, Wenzel P, DeBruin A, Leone G) 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings 2007:300-303 SCOPUS ID: 2-s2.0-36348998108 11/27/2007 8 Citations

Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. (Eiring AM, Neviani P, Santhanam R, Oaks JJ, Chang JS, Notari M, Willis W, Gambacorti-Passerini C, Volinia S, Marcucci G, Caligiuri MA, Leone GW, Perrotti D) Blood 2008 Jan 15;111(2):816-28 PMID: 17925491 PMCID: PMC2200861 SCOPUS ID: 2-s2.0-38349102790 10/11/2007 40 Citations

CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells. (Opavsky R, Wang SH, Trikha P, Raval A, Huang Y, Wu YZ, Rodriguez B, Keller B, Liyanarachchi S, Wei G, Davuluri RV, Weinstein M, Felsher D, Ostrowski M, Leone G, Plass C) PLoS Genet 2007 Sep;3(9):1757-69 PMID: 17907813 PMCID: PMC1994712 SCOPUS ID: 2-s2.0-34848812553 10/03/2007 37 Citations

Detection and visualization of surface-pockets to enable phenotyping studies. (Mosaliganti K, Janoos F, Sharp R, Ridgway R, Machiraju R, Huang K, Wenzel P, deBruin A, Leone G, Saltz J) IEEE Trans Med Imaging 2007 Sep;26(9):1283-90 PMID: 17896599 SCOPUS ID: 2-s2.0-34548538743 09/28/2007 2 Citations

Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis. (Opavsky R, Tsai SY, Guimond M, Arora A, Opavska J, Becknell B, Kaufmann M, Walton NA, Stephens JA, Fernandez SA, Muthusamy N, Felsher DW, Porcu P, Caligiuri MA, Leone G) Proc Natl Acad Sci U S A 2007 Sep 25;104(39):15400-5 PMID: 17881568 PMCID: PMC2000495 SCOPUS ID: 2-s2.0-34848837358 09/21/2007 50 Citations

Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2. (Sáenz-Robles MT, Markovics JA, Chong JL, Opavsky R, Whitehead RH, Leone G, Pipas JM) J Virol 2007 Dec;81(23):13191-9 PMID: 17855529 PMCID: PMC2169091 SCOPUS ID: 2-s2.0-36348937368 09/15/2007 22 Citations

Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. (Chen D, Opavsky R, Pacal M, Tanimoto N, Wenzel P, Seeliger MW, Leone G, Bremner R) PLoS Biol 2007 Jul;5(7):e179 PMID: 17608565 PMCID: PMC1914394 SCOPUS ID: 2-s2.0-34547108871 07/05/2007 73 Citations

Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. (McClellan KA, Ruzhynsky VA, Douda DN, Vanderluit JL, Ferguson KL, Chen D, Bremner R, Park DS, Leone G, Slack RS) Mol Cell Biol 2007 Jul;27(13):4825-43 PMID: 17452454 PMCID: PMC1951492 SCOPUS ID: 2-s2.0-34249781210 04/25/2007 71 Citations

Expression of Cre recombinase in early diploid trophoblast cells of the mouse placenta. (Wenzel PL, Leone G) Genesis 2007 Mar;45(3):129-34 PMID: 17299749 SCOPUS ID: 2-s2.0-34247240533 02/15/2007 54 Citations

Rb is critical in a mammalian tissue stem cell population. (Wenzel PL, Wu L, de Bruin A, Chong JL, Chen WY, Dureska G, Sites E, Pan T, Sharma A, Huang K, Ridgway R, Mosaliganti K, Sharp R, Machiraju R, Saltz J, Yamamoto H, Cross JC, Robinson ML, Leone G) Genes Dev 2007 Jan 01;21(1):85-97 PMID: 17210791 PMCID: PMC1759903 SCOPUS ID: 2-s2.0-33846181043 01/11/2007 78 Citations

Volume rendering phenotype differences in mouse placenta microscopy data (Sharp RP, Ridgway R, Mosaliganti K, Wenzel P, Pan T, De Bruin A, Machiraju R, Huang K, Leone G, Saltz JH) Computing in Science and Engineering January 2007;9(1):38-47 SCOPUS ID: 2-s2.0-33846627257 01/01/2007 9 Citations

E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop. (Timmers C, Sharma N, Opavsky R, Maiti B, Wu L, Wu J, Orringer D, Trikha P, Saavedra HI, Leone G) Mol Cell Biol 2007 Jan;27(1):65-78 PMID: 17167174 PMCID: PMC1800646 SCOPUS ID: 2-s2.0-33845768380 12/15/2006 85 Citations

Examining phenotype differences in mouse placenta with volume rendering and segmentation (Sharp R, Ridgway R, Mosaliganti K, Irfanoglu O, Wenzel P, Machiraju R, De Bruin A, Leone G, Pan T, Huang K, Saltz J) 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006 2006 SCOPUS ID: 2-s2.0-42749106207 12/01/2006

Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation. (Sharma N, Timmers C, Trikha P, Saavedra HI, Obery A, Leone G) J Biol Chem 2006 Nov 24;281(47):36124-31 PMID: 17008321 SCOPUS ID: 2-s2.0-33845987719 09/30/2006 57 Citations

Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. (Dorrance AM, Liu S, Yuan W, Becknell B, Arnoczky KJ, Guimond M, Strout MP, Feng L, Nakamura T, Yu L, Rush LJ, Weinstein M, Leone G, Wu L, Ferketich A, Whitman SP, Marcucci G, Caligiuri MA) J Clin Invest 2006 Oct;116(10):2707-16 PMID: 16981007 PMCID: PMC1564428 SCOPUS ID: 2-s2.0-33749424957 09/19/2006 105 Citations

Registration and 3D visualization of large microscopy images (Mosaliganti K, Pan T, Sharp R, Ridgway R, Iyengar S, Gulacy A, Wenzel P, De Bruin A, Machiraju R, Huang K, Leone G, Saltz J) Progress in Biomedical Optics and Imaging - Proceedings of SPIE 2006;6144 II SCOPUS ID: 2-s2.0-33745124036 06/22/2006 27 Citations

Virtual Microscopy: Distributed Image Storage, Retrieval, Analysis, and Visualization (Pan T, Jewel S, Catalyurek U, Wenzel P, Leone G, Hastings S, Oster S, Langella S, Kurc T, Saltz J, Cowden D) Parallel Computing for Bioinformatics and Computational Biology: Models, Enabling Technologies, and Case Studies 9 June 2005:737-763 SCOPUS ID: 2-s2.0-84890010001 06/09/2005

E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7. (Logan N, Graham A, Zhao X, Fisher R, Maiti B, Leone G, La Thangue NB) Oncogene 2005 Jul 21;24(31):5000-4 PMID: 15897886 SCOPUS ID: 2-s2.0-23744484144 05/18/2005 100 Citations

Distinct capacities of individual E2Fs to induce cell cycle re-entry in postmitotic lens fiber cells of transgenic mice. (Chen Q, Liang D, Yang T, Leone G, Overbeek PA) Dev Neurosci 2004;26(5-6):435-45 PMID: 15855772 SCOPUS ID: 2-s2.0-18644384353 04/28/2005 19 Citations

Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. (Maiti B, Li J, de Bruin A, Gordon F, Timmers C, Opavsky R, Patil K, Tuttle J, Cleghorn W, Leone G) J Biol Chem 2005 May 06;280(18):18211-20 PMID: 15722552 SCOPUS ID: 2-s2.0-24044514663 02/22/2005 156 Citations

Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. (Iavarone A, King ER, Dai XM, Leone G, Stanley ER, Lasorella A) Nature 2004 Dec 23;432(7020):1040-5 PMID: 15616565 SCOPUS ID: 2-s2.0-11144248047 12/24/2004 122 Citations

A NotI-EcoRV promoter library for studies of genetic and epigenetic alterations in mouse models of human malignancies. (Yu L, Liu C, Bennett K, Wu YZ, Dai Z, Vandeusen J, Opavsky R, Raval A, Trikha P, Rodriguez B, Becknell B, Mao C, Lee S, Davuluri RV, Leone G, Van den Veyver IB, Caligiuri MA, Plass C) Genomics 2004 Oct;84(4):647-60 PMID: 15475242 SCOPUS ID: 2-s2.0-4744359915 10/12/2004 22 Citations

Aberrant regulation of survivin by the RB/E2F family of proteins. (Jiang Y, Saavedra HI, Holloway MP, Leone G, Altura RA) J Biol Chem 2004 Sep 24;279(39):40511-20 PMID: 15271987 SCOPUS ID: 2-s2.0-4644348204 07/24/2004 149 Citations

Bone morphogenetic protein 3B silencing in non-small-cell lung cancer. (Dai Z, Popkie AP, Zhu WG, Timmers CD, Raval A, Tannehill-Gregg S, Morrison CD, Auer H, Kratzke RA, Niehans G, Amatschek S, Sommergruber W, Leone GW, Rosol T, Otterson GA, Plass C) Oncogene 2004 Apr 29;23(20):3521-9 PMID: 15116090 SCOPUS ID: 2-s2.0-2442716565 04/30/2004 52 Citations

Rb regulates proliferation and rod photoreceptor development in the mouse retina. (Zhang J, Gray J, Wu L, Leone G, Rowan S, Cepko CL, Zhu X, Craft CM, Dyer MA) Nat Genet 2004 Apr;36(4):351-60 PMID: 14991054 SCOPUS ID: 2-s2.0-1842588322 03/03/2004 177 Citations

Cyclin E and Bcl-xL cooperatively induce cell cycle progression in c-Rel-/- B cells. (Cheng S, Hsia CY, Leone G, Liou HC) Oncogene 2003 Nov 20;22(52):8472-86 PMID: 14627988 SCOPUS ID: 2-s2.0-0347383874 11/25/2003 47 Citations

Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. (de Bruin A, Maiti B, Jakoi L, Timmers C, Buerki R, Leone G) J Biol Chem 2003 Oct 24;278(43):42041-9 PMID: 12893818 SCOPUS ID: 2-s2.0-0142242213 08/02/2003 172 Citations

Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. (de Bruin A, Wu L, Saavedra HI, Wilson P, Yang Y, Rosol TJ, Weinstein M, Robinson ML, Leone G) Proc Natl Acad Sci U S A 2003 May 27;100(11):6546-51 PMID: 12732721 PMCID: PMC164483 SCOPUS ID: 2-s2.0-0037975570 05/07/2003 111 Citations

Inactivation of E2F3 results in centrosome amplification. (Saavedra HI, Maiti B, Timmers C, Altura R, Tokuyama Y, Fukasawa K, Leone G) Cancer Cell 2003 Apr;3(4):333-46 PMID: 12726860 PMCID: PMC3033013 SCOPUS ID: 2-s2.0-0042510099 05/03/2003 63 Citations

Extra-embryonic function of Rb is essential for embryonic development and viability. (Wu L, de Bruin A, Saavedra HI, Starovic M, Trimboli A, Yang Y, Opavska J, Wilson P, Thompson JC, Ostrowski MC, Rosol TJ, Woollett LA, Weinstein M, Cross JC, Robinson ML, Leone G) Nature 2003 Feb 27;421(6926):942-7 PMID: 12607001 SCOPUS ID: 2-s2.0-0037468222 02/28/2003 329 Citations

Molecular cloning and expression of equine calcitonin, calcitonin gene-related peptide-I, and calcitonin gene-related peptide-II. (Toribio RE, Kohn CW, Leone GW, Capen CC, Rosol TJ) Mol Cell Endocrinol 2003 Jan 31;199(1-2):119-28 PMID: 12581884 SCOPUS ID: 2-s2.0-12244313857 02/13/2003 31 Citations

Structural characterization of Rasgrf1 and a novel linked imprinted locus. (de la Puente A, Hall J, Wu YZ, Leone G, Peters J, Yoon BJ, Soloway P, Plass C) Gene 2002 May 29;291(1-2):287-97 PMID: 12095702 SCOPUS ID: 2-s2.0-0037193659 07/04/2002 31 Citations

Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb. (Saavedra HI, Wu L, de Bruin A, Timmers C, Rosol TJ, Weinstein M, Robinson ML, Leone G) Cell Growth Differ 2002 May;13(5):215-25 PMID: 12065245 SCOPUS ID: 2-s2.0-0035997933 06/18/2002 93 Citations

Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. (Cook JG, Park CH, Burke TW, Leone G, DeGregori J, Engel A, Nevins JR) Proc Natl Acad Sci U S A 2002 Feb 05;99(3):1347-52 PMID: 11805305 PMCID: PMC122193 SCOPUS ID: 2-s2.0-0037022387 01/24/2002 102 Citations

DNA damage invokes mismatch repair-dependent cyclin D1 attenuation and retinoblastoma signaling pathways to inhibit CDK2. (Lan Z, Sever-Chroneos Z, Strobeck MW, Park CH, Baskaran R, Edelmann W, Leone G, Knudsen ES) J Biol Chem 2002 Mar 08;277(10):8372-81 PMID: 11726663 SCOPUS ID: 2-s2.0-0037041027 12/01/2001 56 Citations

The E2F1-3 transcription factors are essential for cellular proliferation. (Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G) Nature 2001 Nov 22;414(6862):457-62 PMID: 11719808 SCOPUS ID: 2-s2.0-0035936113 11/24/2001 507 Citations

BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia. (Tanner SM, Austin JL, Leone G, Rush LJ, Plass C, Heinonen K, Mrózek K, Sill H, Knuutila S, Kolitz JE, Archer KJ, Caligiuri MA, Bloomfield CD, de La Chapelle A) Proc Natl Acad Sci U S A 2001 Nov 20;98(24):13901-6 PMID: 11707601 PMCID: PMC61139 SCOPUS ID: 2-s2.0-0035923722 11/15/2001 115 Citations

Fluconazole and Candida krusei fungemia. (Girmenia C, Pagano L, Leone G, Martino P) Arch Intern Med 2001 Oct 08;161(18):2267-9 PMID: 11575996 SCOPUS ID: 2-s2.0-0035828979 11/14/2001 7 Citations

Myc requires distinct E2F activities to induce S phase and apoptosis. (Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, Smith C, Nevins JR) Mol Cell 2001 Jul;8(1):105-13 PMID: 11511364 SCOPUS ID: 2-s2.0-17944375816 08/21/2001 209 Citations

Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein. (Zhao YG, Gilmore R, Leone G, Coffey MC, Weber B, Lee PW) J Biol Chem 2001 Aug 31;276(35):32822-7 PMID: 11438552 SCOPUS ID: 2-s2.0-0035980061 07/05/2001 92 Citations

Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. (Ishida S, Huang E, Zuzan H, Spang R, Leone G, West M, Nevins JR) Mol Cell Biol 2001 Jul;21(14):4684-99 PMID: 11416145 PMCID: PMC87143 SCOPUS ID: 2-s2.0-0034949169 06/21/2001 506 Citations

Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death. (Weng LP, Gimm O, Kum JB, Smith WM, Zhou XP, Wynford-Thomas D, Leone G, Eng C) Hum Mol Genet 2001 Feb 01;10(3):251-8 PMID: 11159944 SCOPUS ID: 2-s2.0-0035253503 02/13/2001 82 Citations

Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway. (Smith DS, Leone G, DeGregori J, Ahmed MN, Qumsiyeh MB, Nevins JR) Cell Growth Differ 2000 Dec;11(12):625-33 PMID: 11149597 SCOPUS ID: 2-s2.0-0034524238 01/10/2001 40 Citations

Complex transcriptional regulatory mechanisms control expression of the E2F3 locus. (Adams MR, Sears R, Nuckolls F, Leone G, Nevins JR) Mol Cell Biol 2000 May;20(10):3633-9 PMID: 10779353 PMCID: PMC85656 SCOPUS ID: 2-s2.0-0034014308 04/25/2000 116 Citations

Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. (Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, Miron A, Nevins JR) Mol Cell Biol 2000 May;20(10):3626-32 PMID: 10779352 PMCID: PMC85655 SCOPUS ID: 2-s2.0-0034011378 04/25/2000 155 Citations

Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase. (Leone G, DeGregori J, Jakoi L, Cook JG, Nevins JR) Proc Natl Acad Sci U S A 1999 Jun 08;96(12):6626-31 PMID: 10359762 PMCID: PMC21965 SCOPUS ID: 2-s2.0-0033536059 06/09/1999 77 Citations

Ras enhances Myc protein stability. (Sears R, Leone G, DeGregori J, Nevins JR) Mol Cell 1999 Feb;3(2):169-79 PMID: 10078200 SCOPUS ID: 2-s2.0-0033082892 03/17/1999 389 Citations

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. (Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams RS, Nevins JR) Genes Dev 1998 Jul 15;12(14):2120-30 PMID: 9679057 PMCID: PMC317011 SCOPUS ID: 2-s2.0-0032528027 07/25/1998 322 Citations

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. (Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS) Proc Natl Acad Sci U S A 1998 Mar 31;95(7):3603-8 PMID: 9520412 PMCID: PMC19882 SCOPUS ID: 2-s2.0-0032584220 05/09/1998 217 Citations

Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth. (Smith EJ, Leone G, Nevins JR) Cell Growth Differ 1998 Apr;9(4):297-303 PMID: 9563849 SCOPUS ID: 2-s2.0-0031815206 05/01/1998 85 Citations

E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. (Kowalik TF, DeGregori J, Leone G, Jakoi L, Nevins JR) Cell Growth Differ 1998 Feb;9(2):113-8 PMID: 9486847 SCOPUS ID: 2-s2.0-0031992159 03/05/1998 190 Citations

Role of the Rb/E2F pathway in cell growth control. (Nevins JR, Leone G, DeGregori J, Jakoi L) J Cell Physiol 1997 Nov;173(2):233-6 PMID: 9365528 SCOPUS ID: 2-s2.0-1842404728 11/20/1997 177 Citations

Distinct roles for E2F proteins in cell growth control and apoptosis. (DeGregori J, Leone G, Miron A, Jakoi L, Nevins JR) Proc Natl Acad Sci U S A 1997 Jul 08;94(14):7245-50 PMID: 9207076 PMCID: PMC23805 SCOPUS ID: 2-s2.0-0030738479 07/08/1997 616 Citations

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. (Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR) Nature 1997 May 22;387(6631):422-6 PMID: 9163430 SCOPUS ID: 2-s2.0-0030995824 05/22/1997 407 Citations

Functional analysis of E2F transcription factor. (Nevins JR, DeGregori J, Jakoi L, Leone G) Methods Enzymol 1997;283:205-19 PMID: 9251021 SCOPUS ID: 2-s2.0-0030755431 01/01/1997 71 Citations

Erratum: Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F (Nature (1997) 387 (422-425)) (Leone G, DeGregori J, Sears R, Jakol L, Nevins JR) Nature 1997;387(6636):932 SCOPUS ID: 2-s2.0-0030757431 01/01/1997 3 Citations

Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. (Ohtani K, DeGregori J, Leone G, Herendeen DR, Kelly TJ, Nevins JR) Mol Cell Biol 1996 Dec;16(12):6977-84 PMID: 8943353 PMCID: PMC231701 SCOPUS ID: 2-s2.0-0029860820 12/01/1996 135 Citations

The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state. (Smith EJ, Leone G, DeGregori J, Jakoi L, Nevins JR) Mol Cell Biol 1996 Dec;16(12):6965-76 PMID: 8943352 PMCID: PMC231700 SCOPUS ID: 2-s2.0-0029909272 12/01/1996 209 Citations

Co-translational trimerization of the reovirus cell attachment protein. (Gilmore R, Coffey MC, Leone G, McLure K, Lee PW) EMBO J 1996 Jun 03;15(11):2651-8 PMID: 8654362 PMCID: PMC450200 SCOPUS ID: 2-s2.0-0029885416 06/03/1996 43 Citations

C-terminal trimerization, but not N-terminal trimerization, of the reovirus cell attachment protein Is a posttranslational and Hsp70/ATP-dependent process. (Leone G, Coffey MC, Gilmore R, Duncan R, Maybaum L, Lee PW) J Biol Chem 1996 Apr 05;271(14):8466-71 PMID: 8626547 SCOPUS ID: 2-s2.0-0029922120 04/05/1996 26 Citations

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. (DeGregori J, Leone G, Ohtani K, Miron A, Nevins JR) Genes Dev 1995 Dec 01;9(23):2873-87 PMID: 7498785 SCOPUS ID: 2-s2.0-0028826881 12/01/1995 202 Citations

Binding of reovirus to receptor leads to conformational changes in viral capsid proteins that are reversible upon virus detachment. (Fernandes J, Tang D, Leone G, Lee PW) J Biol Chem 1994 Jun 24;269(25):17043-7 PMID: 8006009 SCOPUS ID: 2-s2.0-0028298885 06/24/1994 25 Citations

Reovirus protein sigma 1: from cell attachment to protein oligomerization and folding mechanisms. (Lee PW, Leone G) Bioessays 1994 Mar;16(3):199-206 PMID: 8166674 SCOPUS ID: 2-s2.0-0028173791 03/01/1994 9 Citations

The reovirus cell attachment protein possesses two independently active trimerization domains: basis of dominant negative effects. (Leone G, Maybaum L, Lee PW) Cell 1992 Oct 30;71(3):479-88 PMID: 1423608 SCOPUS ID: 2-s2.0-0026466142 10/30/1992 39 Citations

Trimerization of the reovirus cell attachment protein (sigma 1) induces conformational changes in sigma 1 necessary for its cell-binding function. (Leone G, Duncan R, Lee PW) Virology 1991 Oct;184(2):758-61 PMID: 1887593 SCOPUS ID: 2-s2.0-0025955495 10/01/1991 19 Citations

Biochemical and biophysical characterization of the reovirus cell attachment protein sigma 1: evidence that it is a homotrimer. (Strong JE, Leone G, Duncan R, Sharma RK, Lee PW) Virology 1991 Sep;184(1):23-32 PMID: 1871968 PMCID: PMC7130766 SCOPUS ID: 2-s2.0-0025866624 09/01/1991 64 Citations

Conformational and functional analysis of the C-terminal globular head of the reovirus cell attachment protein. (Duncan R, Horne D, Strong JE, Leone G, Pon RT, Yeung MC, Lee PW) Virology 1991 Jun;182(2):810-9 PMID: 2024499 SCOPUS ID: 2-s2.0-0025727528 06/01/1991 38 Citations

The N-terminal heptad repeat region of reovirus cell attachment protein sigma 1 is responsible for sigma 1 oligomer stability and possesses intrinsic oligomerization function. (Leone G, Duncan R, Mah DC, Price A, Cashdollar LW, Lee PW) Virology 1991 May;182(1):336-45 PMID: 2024469 PMCID: PMC7130816 SCOPUS ID: 2-s2.0-0025810915 05/01/1991 36 Citations

The incorporation of reovirus cell attachment protein sigma 1 into virions requires the N-terminal hydrophobic tail and the adjacent heptad repeat region. (Leone G, Mah DC, Lee PW) Virology 1991 May;182(1):346-50 PMID: 2024470 SCOPUS ID: 2-s2.0-0025811406 05/01/1991 33 Citations

The N-terminal quarter of reovirus cell attachment protein sigma 1 possesses intrinsic virion-anchoring function. (Mah DC, Leone G, Jankowski JM, Lee PW) Virology 1990 Nov;179(1):95-103 PMID: 2219743 SCOPUS ID: 2-s2.0-0025051279 11/01/1990 36 Citations

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Gustavo Leone PhD

Sr Associate Dean, Director, Professor

Publications (180)