Faculty Collaboration Database

Nanostructured oxygen sensor--using micelles to incorporate a hydrophobic platinum porphyrin. PLoS One 2012;7(3):e33390

Date

03/30/2012

Pubmed ID

22457758

Pubmed Central ID

PMC3310867

DOI

10.1371/journal.pone.0033390

Scopus ID

2-s2.0-84863353677 (requires institutional sign-in at Scopus site)   47 Citations

Abstract

Hydrophobic platinum(II)-5,10,15,20-tetrakis-(2,3,4,5,6-pentafluorophenyl)-porphyrin (PtTFPP) was physically incorporated into micelles formed from poly(ε-caprolactone)-block-poly(ethylene glycol) to enable the application of PtTFPP in aqueous solution. Micelles were characterized using dynamic light scattering (DLS) and atomic force microscopy (AFM) to show an average diameter of about 140 nm. PtTFPP showed higher quantum efficiency in micellar solution than in tetrahydrofuran (THF) and dichloromethane (CH₂Cl₂). PtTFPP in micelles also exhibited higher photostability than that of PtTFPP suspended in water. PtTFPP in micelles exhibited good oxygen sensitivity and response time. This study provided an efficient approach to enable the application of hydrophobic oxygen sensors in a biological environment.

Author List

Su F, Alam R, Mei Q, Tian Y, Youngbull C, Johnson RH, Meldrum DR

Author

Roger H. Johnson PhD Associate Professor in the Biophysics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Micelles
Microscopy, Atomic Force
Nanostructures
Oxygen
Photochemical Processes
Platinum
Porphyrins
Spectrophotometry, Ultraviolet