Nanostructured oxygen sensor--using micelles to incorporate a hydrophobic platinum porphyrin. PLoS One 2012;7(3):e33390
Date
03/30/2012Pubmed ID
22457758Pubmed Central ID
PMC3310867DOI
10.1371/journal.pone.0033390Scopus ID
2-s2.0-84863353677 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
Hydrophobic platinum(II)-5,10,15,20-tetrakis-(2,3,4,5,6-pentafluorophenyl)-porphyrin (PtTFPP) was physically incorporated into micelles formed from poly(ε-caprolactone)-block-poly(ethylene glycol) to enable the application of PtTFPP in aqueous solution. Micelles were characterized using dynamic light scattering (DLS) and atomic force microscopy (AFM) to show an average diameter of about 140 nm. PtTFPP showed higher quantum efficiency in micellar solution than in tetrahydrofuran (THF) and dichloromethane (CH₂Cl₂). PtTFPP in micelles also exhibited higher photostability than that of PtTFPP suspended in water. PtTFPP in micelles exhibited good oxygen sensitivity and response time. This study provided an efficient approach to enable the application of hydrophobic oxygen sensors in a biological environment.
Author List
Su F, Alam R, Mei Q, Tian Y, Youngbull C, Johnson RH, Meldrum DRAuthor
Roger H. Johnson PhD Associate Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
MicellesMicroscopy, Atomic Force
Nanostructures
Oxygen
Photochemical Processes
Platinum
Porphyrins
Spectrophotometry, Ultraviolet