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Numerical evaluation of spray position for improved nasal drug delivery. Sci Rep 2020 06 29;10(1):10568

Date

07/01/2020

Pubmed ID

32601278

Pubmed Central ID

PMC7324389

DOI

10.1038/s41598-020-66716-0

Scopus ID

2-s2.0-85087009445

Abstract

Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options for sinonasal diseases in humans. However, inconsistency and ambiguity in instructions show a lack of definitive knowledge on best spray use techniques. In this study, we have identified a new usage strategy for nasal sprays available over-the-counter, that registers an average 8-fold improvement in topical delivery of drugs at diseased sites, when compared to prevalent spray techniques. The protocol involves re-orienting the spray axis to harness inertial motion of particulates and has been developed using computational fluid dynamics simulations of respiratory airflow and droplet transport in medical imaging-based digital models. Simulated dose in representative models is validated through in vitro spray measurements in 3D-printed anatomic replicas using the gamma scintigraphy technique. This work breaks new ground in proposing an alternative user-friendly strategy that can significantly enhance topical delivery inside human nose. While these findings can eventually translate into personalized spray usage instructions and hence merit a change in nasal standard-of-care, this study also demonstrates how relatively simple engineering analysis tools can revolutionize everyday healthcare. Finally, with respiratory mucosa as the initial coronavirus infection site, our findings are relevant to intra-nasal vaccines that are in-development, to mitigate the COVID-19 pandemic.

Author List

Basu S, Holbrook LT, Kudlaty K, Fasanmade O, Wu J, Burke A, Langworthy BW, Farzal Z, Mamdani M, Bennett WD, Fine JP, Senior BA, Zanation AM, Ebert CS Jr, Kimple AJ, Thorp BD, Frank-Ito DO, Garcia GJM, Kimbell JS

Author

Guilherme Garcia PhD Assistant Professor in the Biomedical Engineering department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Administration, Inhalation
Administration, Intranasal
Betacoronavirus
Computer Simulation
Coronavirus Infections
Drug Delivery Systems
Humans
Hydrodynamics
Nasal Cavity
Nasal Mucosa
Nasal Sprays
Nebulizers and Vaporizers
Pandemics
Paranasal Sinuses
Pneumonia, Viral
Viral Vaccines
jenkins-FCD Prod-480 9a4deaf152b0b06dd18151814fff2e18f6c05280