Age-Related Memory Impairment Is Associated with Increased zif268 Protein Accumulation and Decreased Rpt6 Phosphorylation. Int J Mol Sci 2020 Jul 28;21(15)
Date
08/01/2020Pubmed ID
32731408Pubmed Central ID
PMC7432048DOI
10.3390/ijms21155352Scopus ID
2-s2.0-85088885330 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Aging is associated with cognitive decline, including impairments in the ability to accurately form and recall memories. Some behavioral and brain changes associated with aging are evident as early as middle age, making the understanding of associated neurobiological mechanisms essential to aid in efforts aimed at slowing cognitive decline throughout the lifespan. Here, we found that both 15-month-old and 22-month-old rats showed impaired memory recall following trace fear conditioning. This behavioral deficit was accompanied by increased zif268 protein accumulation relative to 3-month-old animals in the medial prefrontal cortex, the dorsal and ventral hippocampi, the anterior and posterior retrosplenial cortices, the lateral amygdala, and the ventrolateral periaqueductal gray. Elevated zif268 protein levels corresponded with decreases in phosphorylation of the Rpt6 proteasome regulatory subunit, which is indicative of decreased engagement of activity-driven protein degradation. Together, these results identify several brain regions differentially impacted by aging and suggest that the accumulation of proteins associated with memory retrieval, through reduced proteolytic activity, is associated with age-related impairments in memory retention.
Author List
Trask S, Dulka BN, Helmstetter FJAuthor
Fred Helmstetter PhD Professor in the Psychology / Neuroscience department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
ATPases Associated with Diverse Cellular ActivitiesAging
Animals
Brain
Cognitive Dysfunction
Early Growth Response Protein 1
Male
Memory Disorders
Phosphorylation
Proteasome Endopeptidase Complex
Proteolysis
Rats
Rats, Inbred F344
