Faculty Collaboration Database

Medical College of Wisconsin

CTSI Cores Search Research Informatics REDCap

Fred Helmstetter PhD

Professor

Institution: University of Wisconsin - Milwaukee
Department: Psychology / Neuroscience

Member of the Neuroscience Research Center

Send Message

Request Meeting

Publications (113)

Sex differences in training-induced activity of the ubiquitin proteasome system in the dorsal hippocampus and medial prefrontal cortex of male and female mice. (Beamish SB, Gross KS, Anderson MM, Helmstetter FJ, Frick KM) Learn Mem 2022 Sep;29(9):302-311 PMID: 36206392 PMCID: PMC9488027 SCOPUS ID: 2-s2.0-85139571787 10/08/2022 4 Citations

Isolation driven changes in Iba1-positive microglial morphology are associated with social recognition memory in adults and adolescents. (Ferrara NC, Trask S, Yan L, Padival M, Helmstetter FJ, Rosenkranz JA) Neurobiol Learn Mem 2022 Jul;192:107626 PMID: 35545212 PMCID: PMC9669926 SCOPUS ID: 2-s2.0-85130138649 05/12/2022 6 Citations

Introduction to the Special Issue to Commemorate the Scientific Legacy of David J. Bucci. (Todd TP, Leaton RN, Helmstetter FJ) Neurobiol Learn Mem 2022 Apr;190:107612 PMID: 35358678 SCOPUS ID: 2-s2.0-85127346922 04/01/2022

Contextual control of conditioned pain tolerance and endogenous analgesic systems. (Trask S, Mogil JS, Helmstetter FJ, Stucky CL, Sadler KE) Elife 2022 Mar 11;11 PMID: 35275062 PMCID: PMC8937231 SCOPUS ID: 2-s2.0-85127306322 03/12/2022 4 Citations

Unique roles for the anterior and posterior retrosplenial cortices in encoding and retrieval of memory for context. (Trask S, Helmstetter FJ) Cereb Cortex 2022 Aug 22;32(17):3602-3610 PMID: 35029643 PMCID: PMC9433420 SCOPUS ID: 2-s2.0-85137138664 01/15/2022 7 Citations

Optogenetic inhibition of either the anterior or posterior retrosplenial cortex disrupts retrieval of a trace, but not delay, fear memory. (Trask S, Ferrara NC, Grisales K, Helmstetter FJ) Neurobiol Learn Mem 2021 Nov;185:107530 PMID: 34592468 PMCID: PMC8595712 SCOPUS ID: 2-s2.0-85118748947 10/01/2021 9 Citations

Regulation of learned fear expression through the MgN-amygdala pathway. (Ferrara NC, Trask S, Pullins SE, Helmstetter FJ) Neurobiol Learn Mem 2021 Nov;185:107526 PMID: 34562619 SCOPUS ID: 2-s2.0-85115785081 09/26/2021 4 Citations

Age-Related Memory Impairment and Sex-Specific Alterations in Phosphorylation of the Rpt6 Proteasome Subunit and Polyubiquitination in the Basolateral Amygdala and Medial Prefrontal Cortex. (Dulka BN, Trask S, Helmstetter FJ) Front Aging Neurosci 2021;13:656944 PMID: 33897408 PMCID: PMC8062735 SCOPUS ID: 2-s2.0-85104671720 04/27/2021 17 Citations

The anterior retrosplenial cortex encodes event-related information and the posterior retrosplenial cortex encodes context-related information during memory formation. (Trask S, Pullins SE, Ferrara NC, Helmstetter FJ) Neuropsychopharmacology 2021 Jun;46(7):1386-1392 PMID: 33580135 PMCID: PMC8134488 SCOPUS ID: 2-s2.0-85101004560 02/14/2021 21 Citations

Age-Related Memory Impairment Is Associated with Increased zif268 Protein Accumulation and Decreased Rpt6 Phosphorylation. (Trask S, Dulka BN, Helmstetter FJ) Int J Mol Sci 2020 Jul 28;21(15) PMID: 32731408 PMCID: PMC7432048 SCOPUS ID: 2-s2.0-85088885330 08/01/2020 8 Citations

SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in App^{NL-G-F/NL-G-F} Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling. (Izumi H, Kawahata I, Shinoda Y, Helmstetter FJ, Fukunaga K) Int J Mol Sci 2020 May 28;21(11) PMID: 32481611 PMCID: PMC7312612 SCOPUS ID: 2-s2.0-85085677889 06/03/2020 7 Citations

Decreased cued fear discrimination learning in female rats as a function of estrous phase. (Trask S, Reis DS, Ferrara NC, Helmstetter FJ) Learn Mem 2020 Jun;27(6):254-257 PMID: 32414943 PMCID: PMC7233151 SCOPUS ID: 2-s2.0-85084786762 05/18/2020 16 Citations

Age-related memory deficits are associated with changes in protein degradation in brain regions critical for trace fear conditioning. (Dulka BN, Pullins SE, Cullen PK, Moyer JR Jr, Helmstetter FJ) Neurobiol Aging 2020 Jul;91:160-166 PMID: 32280031 PMCID: PMC7232789 SCOPUS ID: 2-s2.0-85083015866 04/14/2020 12 Citations

The dorsal hippocampus mediates synaptic destabilization and memory lability in the amygdala in the absence of contextual novelty. (Ferrara NC, Trask S, Pullins SE, Helmstetter FJ) Neurobiol Learn Mem 2019 Dec;166:107089 PMID: 31563610 PMCID: PMC6890228 SCOPUS ID: 2-s2.0-85073921038 09/30/2019 10 Citations

GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating. (Ferrara NC, Jarome TJ, Cullen PK, Orsi SA, Kwapis JL, Trask S, Pullins SE, Helmstetter FJ) Sci Rep 2019 Mar 26;9(1):5180 PMID: 30914678 PMCID: PMC6435726 SCOPUS ID: 2-s2.0-85063564102 03/28/2019 33 Citations

Cortico-limbic connectivity changes following fear extinction and relationships with trait anxiety. (Belleau EL, Pedersen WS, Miskovich TA, Helmstetter FJ, Larson CL) Soc Cogn Affect Neurosci 2018 Oct 25;13(10):1037-1046 PMID: 30137604 PMCID: PMC6204483 SCOPUS ID: 2-s2.0-85055616728 08/24/2018 10 Citations

Context memory formation requires activity-dependent protein degradation in the hippocampus. (Cullen PK, Ferrara NC, Pullins SE, Helmstetter FJ) Learn Mem 2017 Nov;24(11):589-596 PMID: 29038220 PMCID: PMC5647928 SCOPUS ID: 2-s2.0-85034736591 10/19/2017 32 Citations

Corrigendum: Psychopaths Show Enhanced Amygdala Activation during Fear Conditioning. (Schultz DH, Balderston NL, Baskin-Sommers AR, Larson CL, Helmstetter FJ) Front Psychol 2017;8:1457 PMID: 28845153 PMCID: PMC5572079 SCOPUS ID: 2-s2.0-85028091449 08/29/2017 1 Citation

Input from the medial geniculate nucleus modulates amygdala encoding of fear memory discrimination. (Ferrara NC, Cullen PK, Pullins SP, Rotondo EK, Helmstetter FJ) Learn Mem 2017 Sep;24(9):414-421 PMID: 28814467 PMCID: PMC5580525 SCOPUS ID: 2-s2.0-85027542844 08/18/2017 26 Citations

Updating Procedures Can Reorganize the Neural Circuit Supporting a Fear Memory. (Kwapis JL, Jarome TJ, Ferrara NC, Helmstetter FJ) Neuropsychopharmacology 2017 Jul;42(8):1688-1697 PMID: 28139682 PMCID: PMC5518901 SCOPUS ID: 2-s2.0-85013440905 02/01/2017 19 Citations

Fluorescence laminar optical tomography for brain imaging: system implementation and performance evaluation. (Azimipour M, Sheikhzadeh M, Baumgartner R, Cullen PK, Helmstetter FJ, Chang WJ, Pashaie R) J Biomed Opt 2017 Jan 01;22(1):16003 PMID: 28056143 PMCID: PMC5997009 SCOPUS ID: 2-s2.0-85009187910 01/06/2017 7 Citations

The effects of stimulus novelty and negativity on BOLD activity in the amygdala, hippocampus, and bed nucleus of the stria terminalis. (Pedersen WS, Balderston NL, Miskovich TA, Belleau EL, Helmstetter FJ, Larson CL) Soc Cogn Affect Neurosci 2017 May 01;12(5):748-757 PMID: 28008079 PMCID: PMC5460050 SCOPUS ID: 2-s2.0-85021380425 12/23/2016 17 Citations

Hippocampal interactions with brain networks that influence learning & memory. (Hannula DE, Helmstetter FJ) Neurobiol Learn Mem 2016 Oct;134 Pt A:1-4 PMID: 27565289 SCOPUS ID: 2-s2.0-84989923424 08/28/2016 3 Citations

Eye movements are captured by a perceptually simple conditioned stimulus in the absence of explicit contingency knowledge. (Hopkins LS, Helmstetter FJ, Hannula DE) Emotion 2016 Dec;16(8):1157-1171 PMID: 27348496 SCOPUS ID: 2-s2.0-84975700584 06/28/2016 16 Citations

Psychopaths Show Enhanced Amygdala Activation during Fear Conditioning. (Schultz DH, Balderston NL, Baskin-Sommers AR, Larson CL, Helmstetter FJ) Front Psychol 2016;7:348 PMID: 27014154 PMCID: PMC4785144 SCOPUS ID: 2-s2.0-84963640839 03/26/2016 26 Citations

CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval. (Jarome TJ, Ferrara NC, Kwapis JL, Helmstetter FJ) Neurobiol Learn Mem 2016 Feb;128:103-9 PMID: 26779588 PMCID: PMC4754128 SCOPUS ID: 2-s2.0-84954515218 01/19/2016 91 Citations

Eye Movements Index Implicit Memory Expression in Fear Conditioning. (Hopkins LS, Schultz DH, Hannula DE, Helmstetter FJ) PLoS One 2015;10(11):e0141949 PMID: 26562298 PMCID: PMC4642991 SCOPUS ID: 2-s2.0-84955493996 11/13/2015 12 Citations

The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning. (Kwapis JL, Jarome TJ, Lee JL, Helmstetter FJ) Neurobiol Learn Mem 2015 Sep;123:110-6 PMID: 26079095 PMCID: PMC4754129 SCOPUS ID: 2-s2.0-84934926723 06/17/2015 74 Citations

Contextual Information Drives the Reconsolidation-Dependent Updating of Retrieved Fear Memories. (Jarome TJ, Ferrara NC, Kwapis JL, Helmstetter FJ) Neuropsychopharmacology 2015 Dec;40(13):3044-52 PMID: 26062788 PMCID: PMC4864640 SCOPUS ID: 2-s2.0-84947021042 06/13/2015 37 Citations

Functionally distinct amygdala subregions identified using DTI and high-resolution fMRI. (Balderston NL, Schultz DH, Hopkins L, Helmstetter FJ) Soc Cogn Affect Neurosci 2015 Dec;10(12):1615-22 PMID: 25969533 PMCID: PMC4666105 SCOPUS ID: 2-s2.0-84952922456 05/15/2015 27 Citations

The role of the medial prefrontal cortex in trace fear extinction. (Kwapis JL, Jarome TJ, Helmstetter FJ) Learn Mem 2014 Jan;22(1):39-46 PMID: 25512576 PMCID: PMC4274329 SCOPUS ID: 2-s2.0-84919344002 12/17/2014 14 Citations

Protein degradation and protein synthesis in long-term memory formation. (Jarome TJ, Helmstetter FJ) Front Mol Neurosci 2014;7:61 PMID: 25018696 PMCID: PMC4072070 SCOPUS ID: 2-s2.0-84903381840 07/16/2014 88 Citations

Prefrontal cortical regulation of fear learning. (Gilmartin MR, Balderston NL, Helmstetter FJ) Trends Neurosci 2014 Aug;37(8):455-64 PMID: 24929864 PMCID: PMC4119830 SCOPUS ID: 2-s2.0-84905119090 06/16/2014 123 Citations

Rapid amygdala responses during trace fear conditioning without awareness. (Balderston NL, Schultz DH, Baillet S, Helmstetter FJ) PLoS One 2014;9(5):e96803 PMID: 24823365 PMCID: PMC4019542 SCOPUS ID: 2-s2.0-84901269641 05/16/2014 23 Citations

The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation. (Jarome TJ, Kwapis JL, Hallengren JJ, Wilson SM, Helmstetter FJ) Learn Mem 2013 Dec 16;21(1):9-13 PMID: 24344179 PMCID: PMC3867711 SCOPUS ID: 2-s2.0-84892611707 12/18/2013 36 Citations

Memory formation for trace fear conditioning requires ubiquitin-proteasome mediated protein degradation in the prefrontal cortex. (Reis DS, Jarome TJ, Helmstetter FJ) Front Behav Neurosci 2013;7:150 PMID: 24167477 PMCID: PMC3805936 SCOPUS ID: 2-s2.0-84886266153 10/30/2013 52 Citations

Does PKM(zeta) maintain memory? (Kwapis JL, Helmstetter FJ) Brain Res Bull 2014 Jun;105:36-45 PMID: 24076105 PMCID: PMC3966985 SCOPUS ID: 2-s2.0-84901495318 10/01/2013 43 Citations

Extinguishing trace fear engages the retrosplenial cortex rather than the amygdala. (Kwapis JL, Jarome TJ, Lee JL, Gilmartin MR, Helmstetter FJ) Neurobiol Learn Mem 2014 Sep;113:41-54 PMID: 24055593 PMCID: PMC3959632 SCOPUS ID: 2-s2.0-84902120286 09/24/2013 44 Citations

CaMKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories. (Jarome TJ, Kwapis JL, Ruenzel WL, Helmstetter FJ) Front Behav Neurosci 2013;7:115 PMID: 24009566 PMCID: PMC3757295 SCOPUS ID: 2-s2.0-84883311821 09/07/2013 84 Citations

Prefrontal activity links nonoverlapping events in memory. (Gilmartin MR, Miyawaki H, Helmstetter FJ, Diba K) J Neurosci 2013 Jun 26;33(26):10910-4 PMID: 23804110 PMCID: PMC3693060 SCOPUS ID: 2-s2.0-84879288858 06/28/2013 76 Citations

How to detect amygdala activity with magnetoencephalography using source imaging. (Balderston NL, Schultz DH, Baillet S, Helmstetter FJ) J Vis Exp 2013 Jun 03(76) PMID: 23770774 PMCID: PMC3726041 SCOPUS ID: 2-s2.0-85003405875 06/19/2013 25 Citations

Dissociation between implicit and explicit responses in postconditioning UCS revaluation after fear conditioning in humans. (Schultz DH, Balderston NL, Geiger JA, Helmstetter FJ) Behav Neurosci 2013 Jun;127(3):357-68 PMID: 23731073 PMCID: PMC3959889 SCOPUS ID: 2-s2.0-84878785514 06/05/2013 26 Citations

NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning. (Gilmartin MR, Kwapis JL, Helmstetter FJ) Learn Mem 2013 May 15;20(6):290-4 PMID: 23676200 PMCID: PMC3677083 SCOPUS ID: 2-s2.0-84879290942 05/17/2013 56 Citations

The effect of threat on novelty evoked amygdala responses. (Balderston NL, Schultz DH, Helmstetter FJ) PLoS One 2013;8(5):e63220 PMID: 23658813 PMCID: PMC3643910 SCOPUS ID: 2-s2.0-84877031808 05/10/2013 22 Citations

Memory accuracy predicts hippocampal mTOR pathway activation following retrieval of contextual fear memory. (Gafford GM, Parsons RG, Helmstetter FJ) Hippocampus 2013 Sep;23(9):842-7 PMID: 23640842 PMCID: PMC3775923 SCOPUS ID: 2-s2.0-84882887548 05/04/2013 25 Citations

The ubiquitin-proteasome system as a critical regulator of synaptic plasticity and long-term memory formation. (Jarome TJ, Helmstetter FJ) Neurobiol Learn Mem 2013 Oct;105:107-16 PMID: 23623827 PMCID: PMC3786694 SCOPUS ID: 2-s2.0-84884203142 04/30/2013 112 Citations

Resting-state connectivity of the amygdala is altered following Pavlovian fear conditioning. (Schultz DH, Balderston NL, Helmstetter FJ) Front Hum Neurosci 2012;6:242 PMID: 22936906 PMCID: PMC3426015 SCOPUS ID: 2-s2.0-84933677561 09/01/2012 47 Citations

The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation. (Jarome TJ, Kwapis JL, Werner CT, Parsons RG, Gafford GM, Helmstetter FJ) Learn Mem 2012 Jun 20;19(7):300-6 PMID: 22723052 PMCID: PMC3381327 SCOPUS ID: 2-s2.0-84864011536 06/23/2012 40 Citations

Intra-amygdala infusion of the protein kinase Mzeta inhibitor ZIP disrupts foreground context fear memory. (Kwapis JL, Jarome TJ, Gilmartin MR, Helmstetter FJ) Neurobiol Learn Mem 2012 Sep;98(2):148-53 PMID: 22659643 PMCID: PMC3424353 SCOPUS ID: 2-s2.0-84865282197 06/05/2012 34 Citations

Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the ventral hippocampus or amygdala, but not the medial prefrontal cortex. (Gilmartin MR, Kwapis JL, Helmstetter FJ) Neurobiol Learn Mem 2012 May;97(4):452-64 PMID: 22469748 PMCID: PMC3358523 SCOPUS ID: 2-s2.0-84861189045 04/04/2012 86 Citations

Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin. (Kwapis JL, Jarome TJ, Schiff JC, Helmstetter FJ) Learn Mem 2011 Nov;18(11):728-32 PMID: 22028394 PMCID: PMC3207254 SCOPUS ID: 2-s2.0-84857081906 10/27/2011 57 Citations

Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala. (Jarome TJ, Werner CT, Kwapis JL, Helmstetter FJ) PLoS One 2011;6(9):e24349 PMID: 21961035 PMCID: PMC3178530 SCOPUS ID: 2-s2.0-80053089627 10/01/2011 153 Citations

Consolidation and reconsolidation of contextual fear memory requires mammalian target of rapamycin-dependent translation in the dorsal hippocampus. (Gafford GM, Parsons RG, Helmstetter FJ) Neuroscience 2011 May 19;182:98-104 PMID: 21439355 PMCID: PMC3087706 SCOPUS ID: 2-s2.0-79955479386 03/29/2011 92 Citations

The human amygdala plays a stimulus specific role in the detection of novelty. (Balderston NL, Schultz DH, Helmstetter FJ) Neuroimage 2011 Apr 15;55(4):1889-98 PMID: 21256226 PMCID: PMC3062695 SCOPUS ID: 2-s2.0-79952694460 01/25/2011 63 Citations

Classical conditioning of autonomic fear responses is independent of contingency awareness. (Schultz DH, Helmstetter FJ) J Exp Psychol Anim Behav Process 2010 Oct;36(4):495-500 PMID: 20973611 PMCID: PMC6510249 SCOPUS ID: 2-s2.0-78049489079 10/27/2010 69 Citations

Regulation of extinction-related plasticity by opioid receptors in the ventrolateral periaqueductal gray matter. (Parsons RG, Gafford GM, Helmstetter FJ) Front Behav Neurosci 2010;4 PMID: 20740074 PMCID: PMC2927240 SCOPUS ID: 2-s2.0-79957553176 08/27/2010 40 Citations

Conditioning with masked stimuli affects the timecourse of skin conductance responses. (Balderston NL, Helmstetter FJ) Behav Neurosci 2010 Aug;124(4):478-89 PMID: 20695647 PMCID: PMC5275764 SCOPUS ID: 2-s2.0-77955813107 08/11/2010 28 Citations

Time-dependent expression of Arc and zif268 after acquisition of fear conditioning. (Lonergan ME, Gafford GM, Jarome TJ, Helmstetter FJ) Neural Plast 2010;2010:139891 PMID: 20592749 PMCID: PMC2877205 SCOPUS ID: 2-s2.0-77953531037 07/02/2010 85 Citations

Trace and contextual fear conditioning require neural activity and NMDA receptor-dependent transmission in the medial prefrontal cortex. (Gilmartin MR, Helmstetter FJ) Learn Mem 2010 Jun;17(6):289-96 PMID: 20504949 PMCID: PMC2884289 SCOPUS ID: 2-s2.0-77953047945 05/28/2010 142 Citations

Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study. (Lee T, Jarome T, Li SJ, Kim JJ, Helmstetter FJ) Neuroreport 2009 Nov 25;20(17):1554-8 PMID: 19858767 PMCID: PMC2783199 SCOPUS ID: 2-s2.0-75149158523 10/28/2009 127 Citations

Introgression of Brown Norway chromosome 1 onto the fawn hooded hypertensive background rescues long-term fear memory deficits. (Jarome TJ, Kwapis JL, Nye SH, Helmstetter FJ) Behav Genet 2010 Jan;40(1):85-92 PMID: 19757016 PMCID: PMC5275762 SCOPUS ID: 2-s2.0-77949310361 09/17/2009 6 Citations

Protein kinase Mzeta maintains fear memory in the amygdala but not in the hippocampus. (Kwapis JL, Jarome TJ, Lonergan ME, Helmstetter FJ) Behav Neurosci 2009 Aug;123(4):844-50 PMID: 19634944 PMCID: PMC2782955 SCOPUS ID: 2-s2.0-67949117136 07/29/2009 72 Citations

An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models. (Clayton T, Chen JL, Ernst M, Richter L, Cromer BA, Morton CJ, Ng H, Kaczorowski CC, Helmstetter FJ, Furtmüller R, Ecker G, Parker MW, Sieghart W, Cook JM) Curr Med Chem 2007;14(26):2755-75 PMID: 18045122 SCOPUS ID: 2-s2.0-36248995374 11/30/2007 60 Citations

Macromolecular synthesis, distributed synaptic plasticity, and fear conditioning. (Helmstetter FJ, Parsons RG, Gafford GM) Neurobiol Learn Mem 2008 Mar;89(3):324-37 PMID: 17977027 PMCID: PMC2297466 SCOPUS ID: 2-s2.0-39849091200 11/03/2007 69 Citations

Activity in the human amygdala corresponds to early, rather than late period autonomic responses to a signal for shock. (Cheng DT, Richards J, Helmstetter FJ) Learn Mem 2007 Jul;14(7):485-90 PMID: 17626906 PMCID: PMC1934343 SCOPUS ID: 2-s2.0-34547618814 07/14/2007 59 Citations

Human amygdala activity during the expression of fear responses. (Cheng DT, Knight DC, Smith CN, Helmstetter FJ) Behav Neurosci 2006 Dec;120(6):1187-95 PMID: 17201461 SCOPUS ID: 2-s2.0-33846099225 01/05/2007 101 Citations

Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons. (Parsons RG, Gafford GM, Helmstetter FJ) J Neurosci 2006 Dec 13;26(50):12977-83 PMID: 17167087 PMCID: PMC6674972 SCOPUS ID: 2-s2.0-33845606405 12/15/2006 219 Citations

The formation of auditory fear memory requires the synthesis of protein and mRNA in the auditory thalamus. (Parsons RG, Riedner BA, Gafford GM, Helmstetter FJ) Neuroscience 2006 Sep 01;141(3):1163-70 PMID: 16766126 PMCID: PMC1698266 SCOPUS ID: 2-s2.0-33746418867 06/13/2006 39 Citations

Long-term stability of fear memory depends on the synthesis of protein but not mRNA in the amygdala. (Parsons RG, Gafford GM, Baruch DE, Riedner BA, Helmstetter FJ) Eur J Neurosci 2006 Apr;23(7):1853-9 PMID: 16623842 PMCID: PMC1698267 SCOPUS ID: 2-s2.0-33645451289 04/21/2006 78 Citations

Effects of post-training hippocampal injections of midazolam on fear conditioning. (Gafford GM, Parsons RG, Helmstetter FJ) Learn Mem 2005;12(6):573-8 PMID: 16322359 PMCID: PMC1356174 SCOPUS ID: 2-s2.0-28844448660 12/03/2005 20 Citations

Antinociception following application of DAMGO to the basolateral amygdala results from a direct interaction of DAMGO with Mu opioid receptors in the amygdala. (Shin MS, Helmstetter FJ) Brain Res 2005 Dec 07;1064(1-2):56-65 PMID: 16289487 SCOPUS ID: 2-s2.0-28844506690 11/18/2005 18 Citations

Amygdala and hippocampal activity during acquisition and extinction of human fear conditioning. (Knight DC, Smith CN, Cheng DT, Stein EA, Helmstetter FJ) Cogn Affect Behav Neurosci 2004 Sep;4(3):317-25 PMID: 15535167 SCOPUS ID: 2-s2.0-5344273995 11/13/2004 204 Citations

Effects of exercise on Pavlovian fear conditioning. (Baruch DE, Swain RA, Helmstetter FJ) Behav Neurosci 2004 Oct;118(5):1123-7 PMID: 15506895 SCOPUS ID: 2-s2.0-5144227245 10/28/2004 67 Citations

Neural substrates mediating human delay and trace fear conditioning. (Knight DC, Cheng DT, Smith CN, Stein EA, Helmstetter FJ) J Neurosci 2004 Jan 07;24(1):218-28 PMID: 14715954 PMCID: PMC6729570 SCOPUS ID: 2-s2.0-0842301331 01/13/2004 204 Citations

Functional MRI of human amygdala activity during Pavlovian fear conditioning: stimulus processing versus response expression. (Cheng DT, Knight DC, Smith CN, Stein EA, Helmstetter FJ) Behav Neurosci 2003 Feb;117(1):3-10 PMID: 12619902 SCOPUS ID: 2-s2.0-0037310406 03/07/2003 132 Citations

Effects of hippocampal injections of a novel ligand selective for the alpha 5 beta 2 gamma 2 subunits of the GABA/benzodiazepine receptor on Pavlovian conditioning. (Bailey DJ, Tetzlaff JE, Cook JM, He X, Helmstetter FJ) Neurobiol Learn Mem 2002 Jul;78(1):1-10 PMID: 12071663 SCOPUS ID: 2-s2.0-0036292157 06/20/2002 39 Citations

Calcitonin gene-related peptide released within the amygdala is involved in Pavlovian auditory fear conditioning. (Kocorowski LH, Helmstetter FJ) Neurobiol Learn Mem 2001 Mar;75(2):149-63 PMID: 11222057 SCOPUS ID: 2-s2.0-0035706090 02/27/2001 30 Citations

Activation of kappa opioid receptors in the rostral ventromedial medulla blocks stress-induced antinociception. (Foo H, Helmstetter FJ) Neuroreport 2000 Oct 20;11(15):3349-52 PMID: 11059900 SCOPUS ID: 2-s2.0-0033784227 11/04/2000 12 Citations

Antinociception produced by mu opioid receptor activation in the amygdala is partly dependent on activation of mu opioid and neurotensin receptors in the ventral periaqueductal gray. (Tershner SA, Helmstetter FJ) Brain Res 2000 May 19;865(1):17-26 PMID: 10814729 SCOPUS ID: 2-s2.0-0034685954 05/18/2000 79 Citations

Expression of antinociception in response to a signal for shock is blocked after selective downregulation of mu-opioid receptors in the rostral ventromedial medulla. (Foo H, Helmstetter FJ) Brain Res Mol Brain Res 2000 Mar 29;76(2):282-8 PMID: 10762703 SCOPUS ID: 2-s2.0-0034728681 04/14/2000 12 Citations

Functional MRI of human Pavlovian fear conditioning: patterns of activation as a function of learning. (Knight DC, Smith CN, Stein EA, Helmstetter FJ) Neuroreport 1999 Nov 26;10(17):3665-70 PMID: 10619663 SCOPUS ID: 2-s2.0-0033607606 01/05/2000 73 Citations

Hypoalgesia elicited by a conditioned stimulus is blocked by a mu, but not a delta or a kappa, opioid antagonist injected into the rostral ventromedial medulla. (Foo H, Helmstetter FJ) Pain 1999 Dec;83(3):427-431 PMID: 10568850 SCOPUS ID: 2-s2.0-0032751455 11/24/1999 26 Citations

Acquisition of fear conditioning in rats requires the synthesis of mRNA in the amygdala. (Bailey DJ, Kim JJ, Sun W, Thompson RF, Helmstetter FJ) Behav Neurosci 1999 Apr;113(2):276-82 PMID: 10357452 SCOPUS ID: 2-s2.0-0032921393 06/05/1999 142 Citations

The role of mu and kappa opioid receptors within the periaqueductal gray in the expression of conditional hypoalgesia. (Bellgowan PS, Helmstetter FJ) Brain Res 1998 Apr 27;791(1-2):83-9 PMID: 9593835 SCOPUS ID: 2-s2.0-0032571778 06/19/1998 49 Citations

Antinociception following opioid stimulation of the basolateral amygdala is expressed through the periaqueductal gray and rostral ventromedial medulla. (Helmstetter FJ, Tershner SA, Poore LH, Bellgowan PS) Brain Res 1998 Jan 01;779(1-2):104-18 PMID: 9473612 SCOPUS ID: 2-s2.0-0031975934 02/25/1998 130 Citations

The effects of central injections of calcitonin gene-related peptide on fear-related behavior. (Poore LH, Helmstetter FJ) Neurobiol Learn Mem 1996 Sep;66(2):241-5 PMID: 8946417 SCOPUS ID: 2-s2.0-0030239113 09/01/1996 31 Citations

Neural systems for the expression of hypoalgesia during nonassociative fear. (Bellgowan PS, Helmstetter FJ) Behav Neurosci 1996 Aug;110(4):727-36 PMID: 8864264 SCOPUS ID: 2-s2.0-0029786448 08/01/1996 68 Citations

Microinfusion of mu but not delta or kappa opioid agonists into the basolateral amygdala results in inhibition of the tail flick reflex in pentobarbital-anesthetized rats. (Helmstetter FJ, Bellgowan PS, Poore LH) J Pharmacol Exp Ther 1995 Oct;275(1):381-8 PMID: 7562575 SCOPUS ID: 2-s2.0-0028786390 10/01/1995 58 Citations

Lesions of the periaqueductal gray and rostral ventromedial medulla disrupt antinociceptive but not cardiovascular aversive conditional responses. (Helmstetter FJ, Tershner SA) J Neurosci 1994 Nov;14(11 Pt 2):7099-108 PMID: 7965101 PMCID: PMC6577286 SCOPUS ID: 2-s2.0-0028072774 11/01/1994 85 Citations

Effects of muscimol applied to the basolateral amygdala on acquisition and expression of contextual fear conditioning in rats. (Helmstetter FJ, Bellgowan PS) Behav Neurosci 1994 Oct;108(5):1005-9 PMID: 7826507 SCOPUS ID: 2-s2.0-0028102957 10/01/1994 214 Citations

Hypoalgesia in response to sensitization during acute noise stress. (Helmstetter FJ, Bellgowan PS) Behav Neurosci 1994 Feb;108(1):177-85 PMID: 8192843 SCOPUS ID: 2-s2.0-0028351483 02/01/1994 32 Citations

Functional mapping of the rat brain during drinking behavior: a fluorodeoxyglucose study. (Gonzalez-Lima F, Helmstetter FJ, Agudo J) Physiol Behav 1993 Sep;54(3):605-12 PMID: 8415957 SCOPUS ID: 2-s2.0-0027182129 09/01/1993 52 Citations

Lesions of the amygdala block conditional hypoalgesia on the tail flick test. (Helmstetter FJ, Bellgowan PS) Brain Res 1993 May 28;612(1-2):253-7 PMID: 8330203 SCOPUS ID: 2-s2.0-0027222896 05/28/1993 118 Citations

Inhibition of the tail flick reflex following microinjection of morphine into the amygdala. (Helmstetter FJ, Bellgowan PS, Tershner SA) Neuroreport 1993 May;4(5):471-4 PMID: 8513121 SCOPUS ID: 2-s2.0-0027294726 05/01/1993 65 Citations

Stress-induced hypoalgesia and defensive freezing are attenuated by application of diazepam to the amygdala. (Helmstetter FJ) Pharmacol Biochem Behav 1993 Feb;44(2):433-8 PMID: 8446677 SCOPUS ID: 2-s2.0-0027446397 02/01/1993 88 Citations

Contribution of the amygdala to learning and performance of conditional fear. (Helmstetter FJ) Physiol Behav 1992 Jun;51(6):1271-6 PMID: 1641430 SCOPUS ID: 2-s2.0-0026770466 06/01/1992 94 Citations

The amygdala is essential for the expression of conditional hypoalgesia. (Helmstetter FJ) Behav Neurosci 1992 Jun;106(3):518-28 PMID: 1319714 SCOPUS ID: 2-s2.0-0026747754 06/01/1992 188 Citations

Differential effects of selective opioid peptide antagonists on the acquisition of pavlovian fear conditioning. (Fanselow MS, Kim JJ, Young SL, Calcagnetti DJ, DeCola JP, Helmstetter FJ, Landeira-Fernandez J) Peptides 1991;12(5):1033-7 PMID: 1686930 SCOPUS ID: 2-s2.0-0026093964 09/01/1991 48 Citations

Effects of systemic and intra-amygdaloid diazepam on long-term habituation of acoustic startle in rats. (Young BJ, Helmstetter FJ, Rabchenuk SA, Leaton RN) Pharmacol Biochem Behav 1991 Aug;39(4):903-9 PMID: 1763110 SCOPUS ID: 2-s2.0-0025999795 08/01/1991 23 Citations

Conditional hypoalgesia is attenuated by naltrexone applied to the periaqueductal gray. (Helmstetter FJ, Landeira-Fernandez J) Brain Res 1990 Dec 24;537(1-2):88-92 PMID: 1964843 SCOPUS ID: 2-s2.0-0025695879 12/24/1990 75 Citations

Role of mu and kappa opioid receptors in conditional fear-induced analgesia: the antagonistic actions of nor-binaltorphimine and the cyclic somatostatin octapeptide, Cys2Tyr3Orn5Pen7-amide. (Fanselow MS, Calcagnetti DJ, Helmstetter FJ) J Pharmacol Exp Ther 1989 Sep;250(3):825-30 PMID: 2570868 SCOPUS ID: 2-s2.0-0024435672 09/01/1989 59 Citations

Modulation of appetitively and aversively motivated behavior by the kappa opioid antagonist MR2266. (Fanselow MS, Calcagnetti DJ, Helmstetter FJ) Behav Neurosci 1989 Jun;103(3):663-72 PMID: 2544207 SCOPUS ID: 2-s2.0-0024390883 06/01/1989 18 Citations

[D-Ala2,Leu5,Cys6]enkephalin: short-term agonist effects and long-term antagonism at delta opioid receptors. (Calcagnetti DJ, Fanselow MS, Helmstetter FJ, Bowen WD) Peptides 1989;10(2):319-26 PMID: 2547203 SCOPUS ID: 2-s2.0-0024473746 03/01/1989 27 Citations

Delta opioid antagonist, 16-Me cyprenorphine, selectively attenuates conditional fear- and DPDPE-induced analgesia on the formalin test. (Fanselow MS, Calcagnetti DJ, Helmstetter FJ) Pharmacol Biochem Behav 1989 Feb;32(2):469-73 PMID: 2542994 SCOPUS ID: 2-s2.0-0024345534 02/01/1989 25 Citations

Changes in feeding and foraging patterns as an antipredator defensive strategy: a laboratory simulation using aversive stimulation in a closed economy. (Fanselow MS, Lester LS, Helmstetter FJ) J Exp Anal Behav 1988 Nov;50(3):361-74 PMID: 3209954 PMCID: PMC1338904 SCOPUS ID: 2-s2.0-0024120387 11/01/1988 69 Citations

Analgesia produced by centrally administered DAGO, DPDPE and U50488H in the formalin test. (Calcagnetti DJ, Helmstetter FJ, Fanselow MS) Eur J Pharmacol 1988 Aug 09;153(1):117-22 PMID: 3215276 SCOPUS ID: 2-s2.0-0023694073 08/09/1988 43 Citations

Ethylketocyclazocine and bremazocine analgesia in neonatal rats. (Helmstetter FJ, Calcagnetti DJ, Cramer CP, Fanselow MS) Pharmacol Biochem Behav 1988 Aug;30(4):817-21 PMID: 3067243 SCOPUS ID: 2-s2.0-0024157702 08/01/1988 12 Citations

Conditional analgesia, defensive freezing, and benzodiazepines. (Fanselow MS, Helmstetter FJ) Behav Neurosci 1988 Apr;102(2):233-43 PMID: 3365319 SCOPUS ID: 2-s2.0-0023747271 04/01/1988 191 Citations

Peripheral versus intracerebroventricular administration of quaternary naltrexone and the enhancement of Pavlovian conditioning. (Fanselow MS, Calcagnetti DJ, Helmstetter FJ) Brain Res 1988 Mar 15;444(1):147-52 PMID: 3359284 SCOPUS ID: 2-s2.0-0023837448 03/15/1988 27 Citations

Strain differences in reversal of conditional analgesia by opioid antagonists. (Helmstetter FJ, Fanselow MS) Behav Neurosci 1987 Oct;101(5):735-7 PMID: 3675853 SCOPUS ID: 2-s2.0-0023555392 10/01/1987 25 Citations

Quaternary naltrexone reveals the central mediation of conditional opioid analgesia. (Calcagnetti DJ, Helmstetter FJ, Fanselow MS) Pharmacol Biochem Behav 1987 Jul;27(3):529-31 PMID: 2821555 SCOPUS ID: 2-s2.0-0023261872 07/01/1987 36 Citations

Central and peripheral injection of quaternary antagonist, SR58002C, reduces drinking. (Calcagnetti DJ, Helmstetter FJ, Fanselow MS) Physiol Behav 1987;40(5):573-5 PMID: 3671520 SCOPUS ID: 2-s2.0-0023636533 01/01/1987 5 Citations

Effects of naltrexone on learning and performance of conditional fear-induced freezing and opioid analgesia. (Helmstetter FJ, Fanselow MS) Physiol Behav 1987;39(4):501-5 PMID: 3575497 SCOPUS ID: 2-s2.0-0023105874 01/01/1987 76 Citations

Last update: 10/08/2022

© 2024 Clinical & Translational Science Institute
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53223

Publication and ontology data from NCBI | Disclaimer and Copyright

This site is a collaborative effort of the Medical College of Wisconsin and the Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number 2UL1TR001436) at the National Institutes of Health (NIH).

Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Fred Helmstetter PhD

Professor

Publications (113)