Faculty Collaboration Database

Undetectable inferior petrosal sinus levels of PTH-related peptide (PTHrP) in patients with ACTH-dependent Cushing's disease. J Endocrinol Invest 2005 Oct;28(9):819-21

Date

12/24/2005

Pubmed ID

16370562

DOI

10.1007/BF03347573

Scopus ID

2-s2.0-31544468688 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

PTH-related peptide (PTHrP), a member of the PTH family, is widely expressed in foetal and adult tissues, and it has been found in benign and malignant tumors, including GH and PRL-secreting adenomas. Conflicting data are reported in literature on serum PTHrP concentrations in patients with Cushing's disease. The aim of the present study was to further evaluate peripheral and inferior petrosal sinus (IPS) serum PTHrP concentrations before and after CRH, in a group of consecutive patients with ACTH-dependent Cushing's disease. Nine patients with active ACTH-dependent Cushing's disease (8 women and 1 man, age +/- SD 41 +/- 13 yr) were submitted to peripheral and IPS sampling under fluoroscopic control before and after iv administration of CRH. All patients were subsequently submitted to transsphenoidal surgery and an ACTH-secreting microadenoma was found in all cases. In all patients, serum IPS and peripheral ACTH measurement were in keeping with the diagnosis of ACTH-dependent Cushing's disease. Serum PTHrP concentrations before and after CRH stimulation were below the sensitivity limit of the assay in all samples, and no gradient between IPS and peripheral sampling was observed. Our data, combined with others reported in literature, indicate that PTHrP release by ACTH-secreting tumors is not a common occurrence. Therefore, we conclude that IPS and peripheral PTHrP are of little clinical usefulness.

Author List

Manetti L, Grasso L, Vignali C, Petruzzi P, Lupi I, Genovesi M, Morselli LL, Cetani F, Acerbi G, Martino E

Author

Lisa Morselli MD, PhD Assistant Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adrenocorticotropic Hormone
Adult
Aged
Calcium
Corticotropin-Releasing Hormone
Female
Humans
Male
Middle Aged
Parathyroid Hormone-Related Protein
Petrosal Sinus Sampling
Pituitary ACTH Hypersecretion