Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway. Int J Mol Sci 2020 Jul 30;21(15)
Date
08/06/2020Pubmed ID
32751750Pubmed Central ID
PMC7432891DOI
10.3390/ijms21155436Scopus ID
2-s2.0-85089131301 (requires institutional sign-in at Scopus site) 43 CitationsAbstract
In response to extracellular stimuli, the Raf/MEK/extracellular signal-regulated kinase (ERK) pathway regulates diverse cellular processes. While mainly known as a mitogenic signaling pathway, the Raf/MEK/ERK pathway can mediate not only cell proliferation and survival but also cell cycle arrest and death in different cell types. Growing evidence suggests that the cell fate toward these paradoxical physiological outputs may be determined not only at downstream effector levels but also at the pathway level, which involves the magnitude of pathway activity, spatial-temporal regulation, and non-canonical functions of the molecular switches in this pathway. This review discusses recent updates on the molecular mechanisms underlying the pathway-mediated growth inhibitory signaling, with a major focus on the regulation mediated at the pathway level.
Author List
Wu PK, Becker A, Park JIAuthor
Jong-In Park PhD Professor in the Biochemistry department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Cell Cycle CheckpointsCell Proliferation
Extracellular Signal-Regulated MAP Kinases
Humans
MAP Kinase Kinase Kinases
MAP Kinase Signaling System
Phosphorylation
raf Kinases
