Medical College of Wisconsin
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Jong-In Park PhD

Jong-In Park PhD profile photo picture

Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

Member of the Cancer Center
Member of the Mellowes Center for Genomic Sciences and Precision Medicine

View Curriculum Vitae

Research Experience

  • Cell Cycle
  • Cell Death
  • Drug Resistance, Neoplasm
  • Gene Expression Regulation, Neoplastic
  • MAP Kinase Signaling System
  • Melanoma
  • Metabolism
  • Mitochondria
  • Molecular Chaperones
  • Pancreatic Neoplasms
  • Precision Medicine
  • Thyroid Neoplasms

    • Publications (52)

  • eIF5A-Independent Role of DHPS in p21CIP1 and Cell Fate Regulation. (Becker AE, Wu PK, Park JI) Int J Mol Sci 2021 Dec 07;22(24) PMID: 34947982 PMCID: PMC8707118 SCOPUS ID: 2-s2.0-85120635476 12/25/2021       1 Citation
  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. (Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC Jr, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR Jr, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cantí C, Cao B, Caraglia M, Caramés B, Carchman EH, Cardenal-Muñoz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmo) Autophagy 2021 Jan;17(1):1-382 PMID: 33634751 PMCID: PMC7996087 SCOPUS ID: 2-s2.0-85102619204 02/27/2021       1306 Citations
  • Mortalin depletion induces MEK/ERK-dependent and ANT/CypD-mediated death in vemurafenib-resistant B-RafV600E melanoma cells. (Wu PK, Hong SK, Park JI) Cancer Lett 2021 Apr 01;502:25-33 PMID: 33440231 PMCID: PMC7897271 SCOPUS ID: 2-s2.0-85099283545 01/14/2021       11 Citations
  • Anticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats. (Kim J, Hagen CE, Kumar SN, Park JI, Zimmerman MA, Hong JC) Transplant Direct 2020 Aug;6(8):e584 PMID: 32766432 PMCID: PMC7371100 SCOPUS ID: 2-s2.0-85094858644 08/09/2020       5 Citations
  • Dabrafenib and Trametinib in Patients With Tumors With BRAFV600E Mutations: Results of the NCI-MATCH Trial Subprotocol H. (Salama AKS, Li S, Macrae ER, Park JI, Mitchell EP, Zwiebel JA, Chen HX, Gray RJ, McShane LM, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Armstrong DK, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT) J Clin Oncol 2020 Nov 20;38(33):3895-3904 PMID: 32758030 PMCID: PMC7676884 SCOPUS ID: 2-s2.0-85093919047 08/08/2020       139 Citations
  • Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway. (Wu PK, Becker A, Park JI) Int J Mol Sci 2020 Jul 30;21(15) PMID: 32751750 PMCID: PMC7432891 SCOPUS ID: 2-s2.0-85089131301 08/06/2020       42 Citations
  • Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability. (Wu PK, Hong SK, Starenki D, Oshima K, Shao H, Gestwicki JE, Tsai S, Park JI) Oncogene 2020 May;39(21):4257-4270 PMID: 32291414 PMCID: PMC7244387 SCOPUS ID: 2-s2.0-85083767959 04/16/2020       18 Citations
  • Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability. (Wu PK, Hong SK, Chen W, Becker AE, Gundry RL, Lin CW, Shao H, Gestwicki JE, Park JI) Sci Signal 2020 Mar 10;13(622) PMID: 32156782 PMCID: PMC7099430 SCOPUS ID: 2-s2.0-85081677231 03/12/2020       21 Citations
  • Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells. (Starenki D, Sosonkina N, Hong SK, Lloyd RV, Park JI) Int J Mol Sci 2019 Apr 26;20(9) PMID: 31027376 PMCID: PMC6540051 SCOPUS ID: 2-s2.0-85065295769 04/28/2019       38 Citations
  • Treatment of Cells and Tissues with Chromate Maximizes Mitochondrial 2Fe2S EPR Signals. (Antholine WE, Vasquez-Vivar J, Quirk BJ, Whelan HT, Wu PK, Park JI, Myers CR) Int J Mol Sci 2019 Mar 06;20(5) PMID: 30845710 PMCID: PMC6429069 SCOPUS ID: 2-s2.0-85062628835 03/09/2019       5 Citations
  • A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses. (Hong SK, Wu PK, Park JI) Cell Signal 2018 Jan;42:11-20 PMID: 28986121 PMCID: PMC5732048 SCOPUS ID: 2-s2.0-85031106212 10/08/2017       21 Citations
  • Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells. (Wu PK, Hong SK, Park JI) Mol Cell Biol 2017 Sep 15;37(18) PMID: 28674184 PMCID: PMC5574043 SCOPUS ID: 2-s2.0-85028363255 07/05/2017       18 Citations
  • Vandetanib and cabozantinib potentiate mitochondria-targeted agents to suppress medullary thyroid carcinoma cells. (Starenki D, Hong SK, Wu PK, Park JI) Cancer Biol Ther 2017 Jul 03;18(7):473-483 PMID: 28475408 PMCID: PMC5639831 SCOPUS ID: 2-s2.0-85020693671 05/06/2017       18 Citations
  • Suppression of B-RafV600E melanoma cell survival by targeting mitochondria using triphenyl-phosphonium-conjugated nitroxide or ubiquinone. (Hong SK, Starenki D, Wu PK, Park JI) Cancer Biol Ther 2017 Feb;18(2):106-114 PMID: 27786591 PMCID: PMC5362989 SCOPUS ID: 2-s2.0-85013783900 10/28/2016       20 Citations
  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). (Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfane) Autophagy 2016;12(1):1-222 PMID: 26799652 PMCID: PMC4835977 SCOPUS ID: 2-s2.0-85013763791 01/23/2016       4274 Citations
  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Azad N, Awale S, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A) Autophagy 1 January 2016;12(2):443 SCOPUS ID: 2-s2.0-85054826264 01/01/2016       23 Citations
  • MEK1/2 Inhibitors: Molecular Activity and Resistance Mechanisms. (Wu PK, Park JI) Semin Oncol 2015 Dec;42(6):849-62 PMID: 26615130 PMCID: PMC4663016 SCOPUS ID: 2-s2.0-84962305085 11/29/2015       84 Citations
  • Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo. (Starenki D, Park JI) Endocrinol Metab (Seoul) 2015 Dec;30(4):593-603 PMID: 26485469 PMCID: PMC4722416 SCOPUS ID: 2-s2.0-84955141252 10/21/2015       16 Citations
  • ERK1/2 can feedback-regulate cellular MEK1/2 levels. (Hong SK, Wu PK, Karkhanis M, Park JI) Cell Signal 2015 Oct;27(10):1939-48 PMID: 26163823 PMCID: PMC4540659 SCOPUS ID: 2-s2.0-84936994796 07/15/2015       21 Citations
  • Phosphoinositide and Erk signaling pathways mediate activity-driven rodent olfactory sensory neuronal survival and stress mitigation. (Kim SY, Mammen A, Yoo SJ, Cho B, Kim EK, Park JI, Moon C, Ronnett GV) J Neurochem 2015 Aug;134(3):486-98 PMID: 25903517 PMCID: PMC4496289 SCOPUS ID: 2-s2.0-84935485906 04/24/2015       13 Citations
  • Active ERK2 is sufficient to mediate growth arrest and differentiation signaling. (Wu PK, Hong SK, Yoon SH, Park JI) FEBS J 2015 Mar;282(6):1017-30 PMID: 25639353 PMCID: PMC4368470 SCOPUS ID: 2-s2.0-84925621653 02/03/2015       18 Citations
  • Sp1 regulates Raf/MEK/ERK-induced p21(CIP1) transcription in TP53-mutated cancer cells. (Karkhanis M, Park JI) Cell Signal 2015 Mar;27(3):479-86 PMID: 25595558 PMCID: PMC4333010 SCOPUS ID: 2-s2.0-84922621429 01/18/2015       26 Citations
  • Pediatric Medullary Thyroid Carcinoma. (Starenki D, Park JI) J Pediatr Oncol 2015;3(2):29-37 PMID: 27014708 PMCID: PMC4803041 01/01/2015    
  • Kinome sequencing reveals RET G691S polymorphism in human neuroendocrine lung cancer cell lines. (Sosonkina N, Hong SK, Starenki D, Park JI) Genes Genomics 2014 Dec;36(6):829-841 PMID: 25530832 PMCID: PMC4270057 SCOPUS ID: 2-s2.0-85027943746 12/23/2014       10 Citations
  • Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells. (Starenki D, Hong SK, Lloyd RV, Park JI) Oncogene 2015 Aug 27;34(35):4624-34 PMID: 25435367 PMCID: PMC4451452 SCOPUS ID: 2-s2.0-84940580797 12/02/2014       63 Citations
  • Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels. (Kim JH, Hong SK, Wu PK, Richards AL, Jackson WT, Park JI) Exp Cell Res 2014 Oct 01;327(2):340-52 PMID: 25128814 PMCID: PMC4164593 SCOPUS ID: 2-s2.0-84907665306 08/17/2014       90 Citations
  • Growth arrest signaling of the Raf/MEK/ERK pathway in cancer. (Park JI) Front Biol (Beijing) 2014 Feb;9(2):95-103 PMID: 24999356 PMCID: PMC4079089 SCOPUS ID: 2-s2.0-84897555396 07/08/2014       41 Citations
  • The Role of STAT3 in Thyroid Cancer. (Sosonkina N, Starenki D, Park JI) Cancers (Basel) 2014 Mar 06;6(1):526-44 PMID: 24662939 PMCID: PMC3980610 SCOPUS ID: 2-s2.0-84896992673 03/26/2014       27 Citations
  • Autophagy sensitivity of neuroendocrine lung tumor cells. (Hong SK, Kim JH, Starenki D, Park JI) Int J Oncol 2013 Dec;43(6):2031-8 PMID: 24126619 PMCID: PMC3834067 SCOPUS ID: 2-s2.0-84891910915 10/16/2013       11 Citations
  • A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase. (Wu PK, Hong SK, Veeranki S, Karkhanis M, Starenki D, Plaza JA, Park JI) Mol Cell Biol 2013 Oct;33(20):4051-67 PMID: 23959801 PMCID: PMC3811686 SCOPUS ID: 2-s2.0-84886885205 08/21/2013       58 Citations
  • Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice. (Starenki D, Singh NK, Jensen DR, Peterson FC, Park JI) Cancer Lett 2013 Oct 01;339(1):144-51 PMID: 23856028 PMCID: PMC3771534 SCOPUS ID: 2-s2.0-84883464713 07/17/2013       13 Citations
  • AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion. (Hong SK, Jeong JH, Chan AM, Park JI) Exp Cell Res 2013 Jul 15;319(12):1732-1743 PMID: 23701950 PMCID: PMC3699957 SCOPUS ID: 2-s2.0-84879604025 05/25/2013       19 Citations
  • Mitochondria-targeted nitroxide, Mito-CP, suppresses medullary thyroid carcinoma cell survival in vitro and in vivo. (Starenki D, Park JI) J Clin Endocrinol Metab 2013 Apr;98(4):1529-40 PMID: 23509102 PMCID: PMC3615196 SCOPUS ID: 2-s2.0-84876220468 03/20/2013       40 Citations
  • Cooperative Cross-Talk between Neuroblastoma Subtypes Confers Resistance to Anaplastic Lymphoma Kinase Inhibition. (Yan X, Kennedy CR, Tilkens SB, Wiedemeier O, Guan H, Park JI, Chan AM) Genes Cancer 2011 May;2(5):538-49 PMID: 21901167 PMCID: PMC3161418 SCOPUS ID: 2-s2.0-80053014894 09/09/2011       9 Citations
  • The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells. (Hong SK, Kim JH, Lin MF, Park JI) Exp Cell Res 2011 Nov 01;317(18):2671-82 PMID: 21871886 PMCID: PMC3189339 SCOPUS ID: 2-s2.0-80053574588 08/30/2011       36 Citations
  • Leukemia inhibitory factor can mediate Ras/Raf/MEK/ERK-induced growth inhibitory signaling in medullary thyroid cancer cells. (Arthan D, Hong SK, Park JI) Cancer Lett 2010 Nov 01;297(1):31-41 PMID: 20570039 SCOPUS ID: 2-s2.0-77956229707 06/24/2010       44 Citations
  • Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling. (Hong SK, Yoon S, Moelling C, Arthan D, Park JI) J Biol Chem 2009 Nov 27;284(48):33006-18 PMID: 19805545 PMCID: PMC2785141 SCOPUS ID: 2-s2.0-70450230440 10/07/2009       69 Citations
  • Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. (Yin W, Park JI, Loeser RF) J Biol Chem 2009 Nov 13;284(46):31972-81 PMID: 19762915 PMCID: PMC2797269 SCOPUS ID: 2-s2.0-70450274965 09/19/2009       151 Citations
  • Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells. (Strock CJ, Park JI, Nakakura EK, Bova GS, Isaacs JT, Ball DW, Nelkin BD) Cancer Res 2006 Aug 01;66(15):7509-15 PMID: 16885348 SCOPUS ID: 2-s2.0-33747875152 08/04/2006       135 Citations
  • Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer. (Strock CJ, Park JI, Rosen DM, Ruggeri B, Denmeade SR, Ball DW, Nelkin BD) J Clin Endocrinol Metab 2006 Jan;91(1):79-84 PMID: 16263812 SCOPUS ID: 2-s2.0-30344439815 11/03/2005       42 Citations
  • The high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae is the major determinant of cAMP levels in stationary phase: involvement of different branches of the Ras-cyclic AMP pathway in stress responses. (Park JI, Grant CM, Dawes IW) Biochem Biophys Res Commun 2005 Feb 04;327(1):311-9 PMID: 15629464 SCOPUS ID: 2-s2.0-11144231398 01/05/2005       60 Citations
  • Interleukin-1beta can mediate growth arrest and differentiation via the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. (Park JI, Strock CJ, Ball DW, Nelkin BD) Cytokine 2005 Feb 07;29(3):125-34 PMID: 15613280 SCOPUS ID: 2-s2.0-11144277904 12/23/2004       28 Citations
  • Regulation and function of trefoil factor family 3 expression in the biliary tree. (Nozaki I, Lunz JG 3rd, Specht S, Park JI, Giraud AS, Murase N, Demetris AJ) Am J Pathol 2004 Dec;165(6):1907-20 PMID: 15579435 PMCID: PMC1618723 SCOPUS ID: 2-s2.0-9644257445 12/08/2004       45 Citations
  • GDNF-induced leukemia inhibitory factor can mediate differentiation via the MEK/ERK pathway in pheochromocytoma cells derived from nf1-heterozygous knockout mice. (Park JI, Powers JF, Tischler AS, Strock CJ, Ball DW, Nelkin BD) Exp Cell Res 2005 Feb 01;303(1):79-88 PMID: 15572029 SCOPUS ID: 2-s2.0-9644295588 12/02/2004       16 Citations
  • IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. (Kim EJ, Park JI, Nelkin BD) J Biol Chem 2005 Feb 11;280(6):4913-20 PMID: 15572361 SCOPUS ID: 2-s2.0-14244267810 12/02/2004       46 Citations
  • Rom2p, the Rho1 GTP/GDP exchange factor of Saccharomyces cerevisiae, can mediate stress responses via the Ras-cAMP pathway. (Park JI, Collinson EJ, Grant CM, Dawes IW) J Biol Chem 2005 Jan 28;280(4):2529-35 PMID: 15545276 SCOPUS ID: 2-s2.0-13244275216 11/17/2004       39 Citations
  • CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth. (Strock CJ, Park JI, Rosen M, Dionne C, Ruggeri B, Jones-Bolin S, Denmeade SR, Ball DW, Nelkin BD) Cancer Res 2003 Sep 01;63(17):5559-63 PMID: 14500395 SCOPUS ID: 2-s2.0-0141592764 09/23/2003       91 Citations
  • Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. (Sriuranpong V, Park JI, Amornphimoltham P, Patel V, Nelkin BD, Gutkind JS) Cancer Res 2003 Jun 01;63(11):2948-56 PMID: 12782602 SCOPUS ID: 2-s2.0-0038581774 06/05/2003       246 Citations
  • The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway. (Park JI, Strock CJ, Ball DW, Nelkin BD) Mol Cell Biol 2003 Jan;23(2):543-54 PMID: 12509453 PMCID: PMC151536 SCOPUS ID: 2-s2.0-0037221065 01/02/2003       112 Citations
  • The cytoplasmic Cu,Zn superoxide dismutase of saccharomyces cerevisiae is required for resistance to freeze-thaw stress. Generation of free radicals during freezing and thawing. (Park JI, Grant CM, Davies MJ, Dawes IW) J Biol Chem 1998 Sep 04;273(36):22921-8 PMID: 9722512 SCOPUS ID: 2-s2.0-0032483373 08/29/1998       124 Citations
  • The freeze-thaw stress response of the yeast Saccharomyces cerevisiae is growth phase specific and is controlled by nutritional state via the RAS-cyclic AMP signal transduction pathway. (Park JI, Grant CM, Attfield PV, Dawes IW) Appl Environ Microbiol 1997 Oct;63(10):3818-24 PMID: 9327544 PMCID: PMC168690 SCOPUS ID: 2-s2.0-0030793730 11/05/1997       112 Citations
  • Cell biological study of the effect of 5-hydroxytryptamine (serotonin) on chick embryogenesis (Joo CN, Park JI, Lee SY, Hwang WI) BMB Reports 23 (1): 142-150 12/29/1990    
    • Last update: 06/13/2022