Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Innate immunity and alpha/gammaherpesviruses: first impressions last a lifetime. Curr Opin Virol 2020 Oct;44:81-89

Date

08/11/2020

Pubmed ID

32777757

Pubmed Central ID

PMC7755754

DOI

10.1016/j.coviro.2020.07.002

Scopus ID

2-s2.0-85089150436 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

Innate immune system is considered the first line of defense during viral invasion, with the wealth of the literature demonstrating innate immune control of diverse viruses during acute infection. What is far less clear is the role of innate immune system during chronic virus infections. This short review focuses on alphaherpesviruses and gammaherpesviruses, two highly prevalent herpesvirus subfamilies that, following a brief, once in a lifetime period of acute lytic infection, establish life-long latent infection that is characterized by sporadic reactivation in an immunocompetent host. In spite of many similarities, these two viral families are characterized by distinct cellular tropism and pathogenesis. Here we focus on the published in vivo studies to review known interactions of these two viral subfamilies with the innate immunity of the intact host, both during acute and, particularly, chronic virus infection.

Author List

Jondle CN, Tarakanova VL

Author

Vera Tarakanova PhD Professor in the Microbiology and Immunology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Alphaherpesvirinae
Animals
Chronic Disease
Gammaherpesvirinae
Host-Pathogen Interactions
Humans
Immunity, Innate
Mice
Virus Latency
Virus Replication