Innate immunity and alpha/gammaherpesviruses: first impressions last a lifetime. Curr Opin Virol 2020 Oct;44:81-89
Date
08/11/2020Pubmed ID
32777757Pubmed Central ID
PMC7755754DOI
10.1016/j.coviro.2020.07.002Scopus ID
2-s2.0-85089150436 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Innate immune system is considered the first line of defense during viral invasion, with the wealth of the literature demonstrating innate immune control of diverse viruses during acute infection. What is far less clear is the role of innate immune system during chronic virus infections. This short review focuses on alphaherpesviruses and gammaherpesviruses, two highly prevalent herpesvirus subfamilies that, following a brief, once in a lifetime period of acute lytic infection, establish life-long latent infection that is characterized by sporadic reactivation in an immunocompetent host. In spite of many similarities, these two viral families are characterized by distinct cellular tropism and pathogenesis. Here we focus on the published in vivo studies to review known interactions of these two viral subfamilies with the innate immunity of the intact host, both during acute and, particularly, chronic virus infection.
Author List
Jondle CN, Tarakanova VLAuthor
Vera Tarakanova PhD Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AlphaherpesvirinaeAnimals
Chronic Disease
Gammaherpesvirinae
Host-Pathogen Interactions
Humans
Immunity, Innate
Mice
Virus Latency
Virus Replication
