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Multi-Level Regulation of Opioid-Induced Respiratory Depression. Physiology (Bethesda) 2020 Nov 01;35(6):391-404

Date

10/15/2020

Pubmed ID

33052772

Pubmed Central ID

PMC7864237

DOI

10.1152/physiol.00015.2020

Scopus ID

2-s2.0-85092886511 (requires institutional sign-in at Scopus site)   26 Citations

Abstract

Opioids depress minute ventilation primarily by reducing respiratory rate. This results from direct effects on the preBötzinger Complex as well as from depression of the Parabrachial/Kölliker-Fuse Complex, which provides excitatory drive to preBötzinger Complex neurons mediating respiratory phase-switch. Opioids also depress awake drive from the forebrain and chemodrive.

Author List

Palkovic B, Marchenko V, Zuperku EJ, Stuth EAE, Stucke AG

Authors

Astrid G. Stucke MD Professor in the Anesthesiology department at Medical College of Wisconsin
Eckehard A. Stuth MD Professor in the Anesthesiology department at Medical College of Wisconsin
Edward J. Zuperku PhD Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Analgesics, Opioid
Animals
Humans
Neurons
Respiratory Center
Respiratory Insufficiency