Multi-Level Regulation of Opioid-Induced Respiratory Depression. Physiology (Bethesda) 2020 Nov 01;35(6):391-404
Date
10/15/2020Pubmed ID
33052772Pubmed Central ID
PMC7864237DOI
10.1152/physiol.00015.2020Scopus ID
2-s2.0-85092886511 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
Opioids depress minute ventilation primarily by reducing respiratory rate. This results from direct effects on the preBötzinger Complex as well as from depression of the Parabrachial/Kölliker-Fuse Complex, which provides excitatory drive to preBötzinger Complex neurons mediating respiratory phase-switch. Opioids also depress awake drive from the forebrain and chemodrive.
Author List
Palkovic B, Marchenko V, Zuperku EJ, Stuth EAE, Stucke AGAuthors
Astrid G. Stucke MD Professor in the Anesthesiology department at Medical College of WisconsinEckehard A. Stuth MD Professor in the Anesthesiology department at Medical College of Wisconsin
Edward J. Zuperku PhD Professor in the Anesthesiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Analgesics, OpioidAnimals
Humans
Neurons
Respiratory Center
Respiratory Insufficiency