Medical College of Wisconsin
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Astrid G. Stucke MD

Professor

Institution: Medical College of Wisconsin
Department: Anesthesiology
Division: Pediatric Anesthesiology
Program: Pediatrics

Member of the Neuroscience Research Center

View Curriculum Vitae

Publications (54)

  • Editorial: Opioid-induced respiratory depression: neural circuits and cellular pathways. (Stucke AG, Levitt ES, Montandon G) Front Physiol 2023;14:1348910 PMID: 38179143 PMCID: PMC10766328 SCOPUS ID: 2-s2.0-85181232400 01/05/2024    
  • Mu-opioid receptor selective superagonists produce prolonged respiratory depression. (Malcolm NJ, Palkovic B, Sprague DJ, Calkins MM, Lanham JK, Halberstadt AL, Stucke AG, McCorvy JD) iScience 2023 Jul 21;26(7):107121 PMID: 37416459 PMCID: PMC10320493 SCOPUS ID: 2-s2.0-85163518147 07/07/2023       6 Citations
  • Changes in pontine and preBötzinger/Bötzinger complex neuronal activity during remifentanil-induced respiratory depression in decerebrate dogs. (Palkovic B, Mustapic S, Saric I, Stuth EAE, Stucke AG, Zuperku EJ) Front Physiol 2023;14:1156076 PMID: 37362432 PMCID: PMC10285059 SCOPUS ID: 2-s2.0-85162654247 06/26/2023    
  • Nitazenes are potent mu-opioid receptor agonists with profound respiratory depression. (Palkovic B, Malcom NJ, McCorvy JD, Langer TM, Callison JJ, Stuth EA, Zuperku EJ, Stucke AG) FASEB J 2022 May;36 Suppl 1 PMID: 35553696 SCOPUS ID: 2-s2.0-85130030561 05/14/2022    
  • Contribution of the caudal medullary raphe to opioid induced respiratory depression. (Palkovic B, Cook-Snyder D, Callison JJ, Langer TM 3rd, Nugent R, Stuth EAE, Zuperku EJ, Stucke AG) Respir Physiol Neurobiol 2022 May;299:103855 PMID: 35124284 PMCID: PMC8897277 SCOPUS ID: 2-s2.0-85124754852 02/07/2022       11 Citations
  • Hepatic artery flow, inspired oxygen, and hemoglobin determine liver tissue saturation measured with visible diffuse reflectance spectroscopy (vis-DRS) in an in vivo swine model. (Voulgarelis S, Fathi F, Yu B, Palkovic B, Chatzizacharias NA, Allen KP, Stucke AG) Pediatr Transplant 2022 Jun;26(4):e14230 PMID: 35064720 SCOPUS ID: 2-s2.0-85123506404 01/23/2022       1 Citation
  • Dose-dependent Respiratory Depression by Remifentanil in the Rabbit Parabrachial Nucleus/Kölliker-Fuse Complex and Pre-Bötzinger Complex. (Palkovic B, Callison JJ, Marchenko V, Stuth EAE, Zuperku EJ, Stucke AG) Anesthesiology 2021 Oct 01;135(4):649-672 PMID: 34352068 PMCID: PMC8489159 SCOPUS ID: 2-s2.0-85115636053 08/06/2021       17 Citations
  • Interaction between the pulmonary stretch receptor and pontine control of expiratory duration. (Zuperku EJ, Hopp FA, Stuth EAE, Stucke AG) Respir Physiol Neurobiol 2021 Nov;293:103715 PMID: 34126261 PMCID: PMC8418273 SCOPUS ID: 2-s2.0-85108097773 06/15/2021       5 Citations
  • Evaluation of visible diffuse reflectance spectroscopy in liver tissue: validation of tissue saturations using extracorporeal circulation. (Voulgarelis S, Fathi F, Stucke AG, Daley KD, Kim J, Zimmerman MA, Hong JC, Starkey N, Allen KP, Yu B) J Biomed Opt 2021 May;26(5) PMID: 34021537 PMCID: PMC8145982 SCOPUS ID: 2-s2.0-85106702253 05/23/2021       4 Citations
  • Anesthesia for children with complete trisomy 18 (Edwards syndrome): A cohort review of 84 anesthesia encounters in nine patients. (Birmingham EE, Stucke AG, Diaz CD) Paediatr Anaesth 2021 Apr;31(4):419-428 PMID: 33644930 SCOPUS ID: 2-s2.0-85101807396 03/02/2021       4 Citations
  • Retrieving multiple magnetic foreign bodies from the glottic entrance and stomach: A case report (Voulgarelis S, Stucke A) Saudi Journal of Anaesthesia January-March 2021;15(1):56-58 SCOPUS ID: 2-s2.0-85099588930 01/01/2021       5 Citations
  • Multi-Level Regulation of Opioid-Induced Respiratory Depression. (Palkovic B, Marchenko V, Zuperku EJ, Stuth EAE, Stucke AG) Physiology (Bethesda) 2020 Nov 01;35(6):391-404 PMID: 33052772 PMCID: PMC7864237 SCOPUS ID: 2-s2.0-85092886511 10/15/2020       26 Citations
  • Endogenous glutamatergic inputs to the Parabrachial Nucleus/Kölliker-Fuse Complex determine respiratory rate. (Navarrete-Opazo AA, Cook-Snyder DR, Miller JR, Callison JJ, McCarthy N, Palkovic B, Stuth EAE, Zuperku EJ, Stucke AG) Respir Physiol Neurobiol 2020 Jun;277:103401 PMID: 32036030 PMCID: PMC7309965 SCOPUS ID: 2-s2.0-85083237275 02/10/2020       22 Citations
  • The contribution of endogenous glutamatergic input in the ventral respiratory column to respiratory rhythm. (Cook-Snyder DR, Miller JR, Navarrete-Opazo AA, Callison JJ, Peterson RC, Hopp FA, Stuth EAE, Zuperku EJ, Stucke AG) Respir Physiol Neurobiol 2019 Feb;260:37-52 PMID: 30502519 PMCID: PMC6397772 SCOPUS ID: 2-s2.0-85058568248 12/07/2018       15 Citations
  • Inputs to medullary respiratory neurons from a pontine subregion that controls breathing frequency. (Zuperku EJ, Stucke AG, Krolikowski JG, Tomlinson J, Hopp FA, Stuth EA) Respir Physiol Neurobiol 2019 Jul;265:127-140 PMID: 29964165 PMCID: PMC6310670 SCOPUS ID: 2-s2.0-85049327239 07/03/2018       21 Citations
  • A Subregion of the Parabrachial Nucleus Partially Mediates Respiratory Rate Depression from Intravenous Remifentanil in Young and Adult Rabbits. (Miller JR, Zuperku EJ, Stuth EAE, Banerjee A, Hopp FA, Stucke AG) Anesthesiology 2017 Sep;127(3):502-514 PMID: 28590302 PMCID: PMC5561451 SCOPUS ID: 2-s2.0-85020254103 06/08/2017       35 Citations
  • Characteristics of breathing rate control mediated by a subregion within the pontine parabrachial complex. (Zuperku EJ, Stucke AG, Hopp FA, Stuth EA) J Neurophysiol 2017 Mar 01;117(3):1030-1042 PMID: 27974449 PMCID: PMC5338614 SCOPUS ID: 2-s2.0-85014611292 12/16/2016       27 Citations
  • Should Deidentified Case Data Be Treated as Independent Data Points? (Stucke AG, Stuth EA, Berens RJ) Anesthesiology 2016 Jun;124(6):1418-9 PMID: 27187131 SCOPUS ID: 2-s2.0-84968877252 05/18/2016    
  • Activation of 5-HT1A receptors in the preBötzinger region has little impact on the respiratory pattern. (Radocaj T, Mustapic S, Prkic I, Stucke AG, Hopp FA, Stuth EA, Zuperku EJ) Respir Physiol Neurobiol 2015 Jul;212-214:9-19 PMID: 25850079 SCOPUS ID: 2-s2.0-84928340110 04/08/2015       11 Citations
  • Opioid-induced Respiratory Depression Is Only Partially Mediated by the preBötzinger Complex in Young and Adult Rabbits In Vivo. (Stucke AG, Miller JR, Prkic I, Zuperku EJ, Hopp FA, Stuth EA) Anesthesiology 2015 Jun;122(6):1288-98 PMID: 25751234 PMCID: PMC4639929 SCOPUS ID: 2-s2.0-84937512318 03/10/2015       38 Citations
  • Automatic classification of canine PRG neuronal discharge patterns using K-means clustering. (Zuperku EJ, Prkic I, Stucke AG, Miller JR, Hopp FA, Stuth EA) Respir Physiol Neurobiol 2015 Feb 01;207:28-39 PMID: 25511381 PMCID: PMC4638195 SCOPUS ID: 2-s2.0-84920141232 12/17/2014       10 Citations
  • Can we tell emergence agitation from pain? Comment on Bortone et al.: the effect of fentanyl and clonidine on early postoperative negative behavior in children. (Stucke AG, Weisman SJ) Paediatr Anaesth 2014 Oct;24(10):1114 PMID: 25196292 SCOPUS ID: 2-s2.0-84907982019 09/10/2014       2 Citations
  • Droperidol transiently prolongs the QT interval in children undergoing single ventricle palliation. (Scott JP, Stuth EA, Stucke AG, Cava JR, Berens RJ) Pediatr Cardiol 2015 Jan;36(1):196-204 PMID: 25087057 SCOPUS ID: 2-s2.0-84937210854 08/05/2014       4 Citations
  • Effects of anesthetics, sedatives, and opioids on ventilatory control. (Stuth EA, Stucke AG, Zuperku EJ) Compr Physiol 2012 Oct;2(4):2281-367 PMID: 23720250 SCOPUS ID: 2-s2.0-84891708026 05/31/2013       16 Citations
  • Pontine μ-opioid receptors mediate bradypnea caused by intravenous remifentanil infusions at clinically relevant concentrations in dogs. (Prkic I, Mustapic S, Radocaj T, Stucke AG, Stuth EA, Hopp FA, Dean C, Zuperku EJ) J Neurophysiol 2012 Nov;108(9):2430-41 PMID: 22875901 PMCID: PMC3545180 SCOPUS ID: 2-s2.0-84868322892 08/10/2012       64 Citations
  • Perioperative opiate requirements in children with previous opiate infusion. (Fanning JJ, Stucke AG, Christensen MA, Cassidy LD, Berens RJ) Paediatr Anaesth 2012 Mar;22(3):203-8 PMID: 22070472 SCOPUS ID: 2-s2.0-84856267303 11/11/2011       5 Citations
  • The effect of caudal vs intravenous morphine on early extubation and postoperative analgesic requirements for stage 2 and 3 single-ventricle palliation: a double blind randomized trial. (Stuth EA, Berens RJ, Staudt SR, Robertson FA, Scott JP, Stucke AG, Hoffman GM, Troshynski TJ, Tweddell JS, Zuperku EJ) Paediatr Anaesth 2011 Apr;21(4):441-53 PMID: 21306473 SCOPUS ID: 2-s2.0-79952471592 02/11/2011       20 Citations
  • Clinically relevant infusion rates of mu-opioid agonist remifentanil cause bradypnea in decerebrate dogs but not via direct effects in the pre-Bötzinger complex region. (Mustapic S, Radocaj T, Sanchez A, Dogas Z, Stucke AG, Hopp FA, Stuth EA, Zuperku EJ) J Neurophysiol 2010 Jan;103(1):409-18 PMID: 19906886 PMCID: PMC2807229 SCOPUS ID: 2-s2.0-74049097521 11/13/2009       52 Citations
  • Role of inhibitory neurotransmission in the control of canine hypoglossal motoneuron activity in vivo. (Sanchez A, Mustapic S, Zuperku EJ, Stucke AG, Hopp FA, Stuth EA) J Neurophysiol 2009 Mar;101(3):1211-21 PMID: 19091929 PMCID: PMC2666418 SCOPUS ID: 2-s2.0-64749116760 12/19/2008       5 Citations
  • Opioid receptors on bulbospinal respiratory neurons are not activated during neuronal depression by clinically relevant opioid concentrations. (Stucke AG, Zuperku EJ, Sanchez A, Tonkovic-Capin M, Tonkovic-Capin V, Mustapic S, Stuth EA) J Neurophysiol 2008 Nov;100(5):2878-88 PMID: 18815346 PMCID: PMC2585400 SCOPUS ID: 2-s2.0-57049139355 09/26/2008       23 Citations
  • Anesthetic effects on synaptic transmission and gain control in respiratory control. (Stuth EA, Stucke AG, Brandes IF, Zuperku EJ) Respir Physiol Neurobiol 2008 Dec 10;164(1-2):151-9 PMID: 18583201 SCOPUS ID: 2-s2.0-53849141477 06/28/2008       11 Citations
  • Major components of endogenous neurotransmission underlying the discharge activity of hypoglossal motoneurons in vivo. (Zuperku EJ, Brandes IF, Stucke AG, Sanchez A, Hopp FA, Stuth EA) Adv Exp Med Biol 2008;605:279-84 PMID: 18085286 SCOPUS ID: 2-s2.0-38449120437 12/19/2007       7 Citations
  • Isoflurane depresses the response of inspiratory hypoglossal motoneurons to serotonin in vivo. (Brandes IF, Zuperku EJ, Stucke AG, Hopp FA, Jakovcevic D, Stuth EA) Anesthesiology 2007 Apr;106(4):736-45 PMID: 17413911 SCOPUS ID: 2-s2.0-34147182706 04/07/2007       11 Citations
  • Hemoglobin M (Milwaukee) affects arterial oxygen saturation and makes pulse oximetry unreliable. (Stucke AG, Riess ML, Connolly LA) Anesthesiology 2006 Apr;104(4):887-8 PMID: 16571987 SCOPUS ID: 2-s2.0-33645634217 03/31/2006       12 Citations
  • Serotonergic modulation of inspiratory hypoglossal motoneurons in decerebrate dogs. (Brandes IF, Zuperku EJ, Stucke AG, Jakovcevic D, Hopp FA, Stuth EA) J Neurophysiol 2006 Jun;95(6):3449-59 PMID: 16495364 PMCID: PMC2582383 SCOPUS ID: 2-s2.0-33744938895 02/24/2006       29 Citations
  • Sevoflurane depresses glutamatergic neurotransmission to brainstem inspiratory premotor neurons but not postsynaptic receptor function in a decerebrate dog model. (Stucke AG, Zuperku EJ, Tonkovic-Capin V, Krolo M, Hopp FA, Kampine JP, Stuth EA) Anesthesiology 2005 Jul;103(1):50-6 PMID: 15983456 SCOPUS ID: 2-s2.0-21744446111 06/29/2005       17 Citations
  • Sevoflurane enhances gamma-aminobutyric acid type A receptor function and overall inhibition of inspiratory premotor neurons in a decerebrate dog model. (Stucke AG, Zuperku EJ, Krolo M, Brandes IF, Hopp FA, Kampine JP, Stuth EA) Anesthesiology 2005 Jul;103(1):57-64 PMID: 15983457 SCOPUS ID: 2-s2.0-21744436491 06/29/2005       21 Citations
  • Central effects of general anesthesia (Stuth EAE, Zuperku EJ, Stucke AG) Pharmacology and Pathophysiology of the Control of Breathing 1 January 2005:571-652 SCOPUS ID: 2-s2.0-53849110694 01/01/2005       6 Citations
  • Subtype composition and responses of respiratory neurons in the pre-botzinger region to pulmonary afferent inputs in dogs. (Krolo M, Tonkovic-Capin V, Stucke AG, Stuth EA, Hopp FA, Dean C, Zuperku EJ) J Neurophysiol 2005 May;93(5):2674-87 PMID: 15601729 SCOPUS ID: 2-s2.0-17644375473 12/17/2004       27 Citations
  • Droperidol for perioperative sedation causes a transient prolongation of the QTc time in children under volatile anesthesia. (Stuth EA, Stucke AG, Cava JR, Hoffman GM, Berens RJ) Paediatr Anaesth 2004 Oct;14(10):831-7 PMID: 15385011 SCOPUS ID: 2-s2.0-4944220495 09/24/2004       16 Citations
  • Halothane enhances gamma-aminobutyric acid receptor type A function but does not change overall inhibition in inspiratory premotor neurons in a decerebrate dog model. (Stucke AG, Zuperku EJ, Tonkovic-Capin V, Krolo M, Hopp FA, Kampine JP, Stuth EA) Anesthesiology 2003 Dec;99(6):1303-12 PMID: 14639142 SCOPUS ID: 2-s2.0-0344420350 11/26/2003       6 Citations
  • Complete staged palliation of hypoplastic left heart syndrome in a child with cystic fibrosis. (Stuth EA, Stucke AG, Fedderly RT, Tweddell JS) Paediatr Anaesth 2003 May;13(4):345-8 PMID: 12753450 SCOPUS ID: 2-s2.0-0038053185 05/20/2003       1 Citation
  • Halothane depresses glutamatergic neurotransmission to brain stem inspiratory premotor neurons in a decerebrate dog model. (Stucke AG, Zuperku EJ, Tonkovic-Capin V, Tonkovic-Capin M, Hopp FA, Kampine JP, Stuth EA) Anesthesiology 2003 Apr;98(4):897-905 PMID: 12657851 SCOPUS ID: 2-s2.0-0037381082 03/27/2003       12 Citations
  • Differential processing of excitation by GABAergic gain modulation in canine caudal ventral respiratory group neurons. (Tonkovic-Capin V, Stucke AG, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ) J Neurophysiol 2003 Feb;89(2):862-70 PMID: 12574464 SCOPUS ID: 2-s2.0-0037319226 02/08/2003       19 Citations
  • Another possible mechanism for bronchospasm after rapacuronium. (Stuth EA, Stucke AG, Setlock MA) Anesthesiology 2002 Jun;96(6):1528-9 PMID: 12170075 SCOPUS ID: 2-s2.0-0036264045 08/10/2002       2 Citations
  • Effects of halothane and sevoflurane on inhibitory neurotransmission to medullary expiratory neurons in a decerebrate dog model. (Stucke AG, Stuth EA, Tonkovic-Capin V, Tonkovic-Capin M, Hopp FA, Kampine JP, Zuperku EJ) Anesthesiology 2002 Apr;96(4):955-62 PMID: 11964605 SCOPUS ID: 2-s2.0-0036201402 04/20/2002       21 Citations
  • Differential modulation of respiratory neuronal discharge patterns by GABA(A) receptor and apamin-sensitive K(+) channel antagonism. (Tonkovic-Capin V, Stucke AG, Stuth EA, Tonkovic-Capin M, Krolo M, Hopp FA, McCrimmon DR, Zuperku EJ) J Neurophysiol 2001 Nov;86(5):2363-73 PMID: 11698526 SCOPUS ID: 2-s2.0-0035652623 11/08/2001       18 Citations
  • Use of rapacuronium in a child with spinal muscular atrophy. (Stucke AG, Stuth EA) Paediatr Anaesth 2001 Nov;11(6):725-8 PMID: 11696151 SCOPUS ID: 2-s2.0-0034756344 11/07/2001       13 Citations
  • Successful resuscitation of a child after exsanguination due to aortoesophageal fistula from undiagnosed foreign body. (Stuth EA, Stucke AG, Cohen RD, Jaquiss RD, Kugathasan S, Litwin SB) Anesthesiology 2001 Oct;95(4):1025-6 PMID: 11605901 SCOPUS ID: 2-s2.0-0034786076 10/19/2001       17 Citations
  • Effects of sevoflurane on excitatory neurotransmission to medullary expiratory neurons and on phrenic nerve activity in a decerebrate dog model. (Stucke AG, Stuth EA, Tonkovic-Capin V, Tonkovic-Capin M, Hopp FA, Kampine JP, Zuperku EJ) Anesthesiology 2001 Aug;95(2):485-91 PMID: 11506124 SCOPUS ID: 2-s2.0-0034894854 08/17/2001       29 Citations
  • Negative-pressure pulmonary edema in a child with hiccups during induction. (Mandal NG) Anesthesiology 2001 Feb;94(2):378-9 PMID: 11176114 SCOPUS ID: 2-s2.0-0035141396 02/15/2001       1 Citation
  • Effects of halothane on excitatory neurotransmission to medullary expiratory neurons in a decerebrate dog model. (Stuth EA, Krolo M, Stucke AG, Tonkovic-Capin M, Tonkovic-Capin V, Hopp FA, Kampine JP, Zuperku EJ) Anesthesiology 2000 Dec;93(6):1474-81 PMID: 11149443 SCOPUS ID: 2-s2.0-0033637316 01/10/2001       25 Citations
  • Desflurane induces only minor Ca2+ release from the sarcoplasmic reticulum of mammalian skeletal muscle. (Kunst G, Stucke AG, Graf BM, Martin E, Fink RH) Anesthesiology 2000 Sep;93(3):832-6 PMID: 10969318 SCOPUS ID: 2-s2.0-0033811966 09/02/2000       19 Citations
  • Negative-pressure pulmonary edema in a child with hiccups during induction. (Stuth EA, Stucke AG, Berens RJ) Anesthesiology 2000 Jul;93(1):282-4 PMID: 10861177 SCOPUS ID: 2-s2.0-0033917134 06/22/2000       25 Citations
    • Last update: 03/06/2024