Medical College of Wisconsin
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An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase. FEBS Lett 1995 Oct 23;374(1):122-4



Pubmed ID





Lymphatic filariasis is caused by infection with the filarial nematodes Brugia malayi, Brugia timori, Wuchereria bancrofti and Onchocerca volvulus which collectively infect about 200 million persons throughout the world. Protein sequence homology analysis of a major nematode antigen suggested that it was a class II aminoacyl-tRNA synthetase. The overproduction, purification and verification that the major B. malayi antigen is an asparaginyl-tRNA synthetase is described.

Author List

Kron M, Marquard K, Härtlein M, Price S, Leberman R


Michael Kron MD Director, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Amino Acid Sequence
Amino Acyl-tRNA Synthetases
Antigens, Helminth
Aspartate-tRNA Ligase
Base Sequence
Brugia malayi
DNA Primers
Immunodominant Epitopes
Molecular Sequence Data
RNA, Transfer, Amino Acyl
RNA, Transfer, Asn
Recombinant Fusion Proteins
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a