Medical College of Wisconsin
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Michael Kron MD

Michael Kron MD profile photo picture

Director, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Infectious Disease
Program: Administration

View Curriculum Vitae

Clinical Expertise

  • Parasitology
  • Tropical Medicine

    • MCW Program / Core Facilities

  • Program in International Health
    Biotechnology and Bioengineering Center

    • Publications (66)

  • Whole Genome Sequence of a Treponema pallidum Strain From a Formalin-Fixed, Paraffin-Embedded Fine Needle Aspirate of a Cervical Lymph Node. (Aldrete S, Kroft SH, Romeis E, Lieberman NAP, Greninger AL, Giacani L, Kron MA) Sex Transm Dis 2023 Aug 01;50(8):550-552 PMID: 37165832 SCOPUS ID: 2-s2.0-85164282926 05/11/2023    
  • Evaluation of the angiogenic properties of Brugia malayi asparaginyl-tRNA synthetase and its mutants: A study on the molecular target for antifilarial drug development. (Chandrasekar R, Sivanesan S, Natarajan M, Naveena K, Preetha N, Karthika S, Vimalraj S, Kron M, Dhanasekaran A) Mol Biochem Parasitol 2021 Nov;246:111426 PMID: 34666104 SCOPUS ID: 2-s2.0-85117382334 10/20/2021       2 Citations
  • Postgraduate programs in biochemistry and molecular biology: A parallel session at the IUBMB/PSBMB 2019 "Harnessing Interdisciplinary Education in Biochemistry and Molecular Biology" conference. (Estacio RC, Kron MA, Janlav M, Yu GFB, Macaulay JO) Biochem Mol Biol Educ 2020 Nov;48(6):625-630 PMID: 33068300 SCOPUS ID: 2-s2.0-85092674858 10/18/2020    
  • Academic Medicine and Science Diplomacy: Medical Education in Iraq. (Kron M, Roenius M, Alqortasi MAM, Alhaidari T, Hussein M, Hameed EK, Salih IK) Acad Med 2019 Dec;94(12):1884-1890 PMID: 31365401 SCOPUS ID: 2-s2.0-85075959386 08/01/2019       1 Citation
  • Persistence of Schistosoma japonicum DNA in a Kidney-Liver Transplant Recipient. (Kron M, Gordon C, Bauers T, Lu Z, Mahatme S, Shah J, Saeian K, McManus DP) Am J Trop Med Hyg 2019 Mar;100(3):584-587 PMID: 30628570 PMCID: PMC6402933 SCOPUS ID: 2-s2.0-85062624381 01/11/2019       4 Citations
  • Mental health indicators in APEC. (Kron M, Grewal R, Idso J, Prough M, Sundaram C, Klein S, Nida J, Jumbam D, Garringer K) Int J Soc Psychiatry 2019 Mar;65(2):92-97 PMID: 30595067 SCOPUS ID: 2-s2.0-85059554778 01/01/2019       2 Citations
  • Immune Response to Brugia malayi Asparaginyl-tRNA Synthetase in Balb/c Mice and Human Clinical Samples of Lymphatic Filariasis. (Hameed A, Natarajan M, Jabbar S, Dhanasekaran JJ, Kumar K, Sivanesan S, Kron M, Dhanasekaran A) Lymphat Res Biol 2019 Aug;17(4):447-456 PMID: 30570354 SCOPUS ID: 2-s2.0-85070831158 12/21/2018       2 Citations
  • Field-Effect Transistor Biosensor for Rapid Detection of Ebola Antigen. (Chen Y, Ren R, Pu H, Guo X, Chang J, Zhou G, Mao S, Kron M, Chen J) Sci Rep 2017 Sep 08;7(1):10974 PMID: 28887479 PMCID: PMC5591202 SCOPUS ID: 2-s2.0-85028993914 09/10/2017       114 Citations
  • Porous carbon and Prussian blue composite: A highly sensitive electrochemical platform for glucose biosensing (Thakur B, Guo X, Chang J, Kron M, Chen J) Sensing and Bio-Sensing Research June 2017;14:47-53 SCOPUS ID: 2-s2.0-85020134694 06/01/2017       10 Citations
  • Correction: Brugia malayi Asparaginyl-tRNA Synthetase Stimulates Endothelial Cell Proliferation, Vasodilation and Angiogenesis. (D JJ, Dhanraj M, Solaiappan S, Sivanesan S, Kron M, Dhanasekaran A) PLoS One 2017;12(2):e0171402 PMID: 28152101 PMCID: PMC5289596 SCOPUS ID: 2-s2.0-85011552406 02/06/2017    
  • Brugia malayi Asparaginyl-tRNA Synthetase Stimulates Endothelial Cell Proliferation, Vasodilation and Angiogenesis. (D JJ, Dhanraj M, Solaiappan S, Sivanesan S, Kron M, Dhanasekaran A) PLoS One 2016;11(1):e0146132 PMID: 26751209 PMCID: PMC4709172 SCOPUS ID: 2-s2.0-84954562439 01/12/2016       11 Citations
  • Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites. (Rateb ME, Yang D, Vodanovic-Jankovic S, Yu Z, Kron MA, Shen B) J Antibiot (Tokyo) 2015 Aug;68(8):540-2 PMID: 25735843 SCOPUS ID: 2-s2.0-84940484072 03/05/2015       10 Citations
  • Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J. (Rateb ME, Yu Z, Yan Y, Yang D, Huang T, Vodanovic-Jankovic S, Kron MA, Shen B) J Antibiot (Tokyo) 2014 Jan;67(1):127-32 PMID: 23715040 PMCID: PMC3773001 SCOPUS ID: 2-s2.0-84893112499 05/30/2013       26 Citations
  • Nematode asparaginyl-tRNA synthetase resolves intestinal inflammation in mice with T-cell transfer colitis. (Kron MA, Metwali A, Vodanovic-Jankovic S, Elliott D) Clin Vaccine Immunol 2013 Feb;20(2):276-81 PMID: 23254300 PMCID: PMC3571265 SCOPUS ID: 2-s2.0-84874880292 12/21/2012       34 Citations
  • New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase. (Yu Z, Vodanovic-Jankovic S, Kron M, Shen B) Org Lett 2012 Sep 21;14(18):4946-9 PMID: 22967068 PMCID: PMC3460372 SCOPUS ID: 2-s2.0-84868245096 09/13/2012       45 Citations
  • Interleukin-8-like activity in a filarial asparaginyl-tRNA synthetase. (Kron MA, Wang C, Vodanovic-Jankovic S, Howard OM, Kuhn LA) Mol Biochem Parasitol 2012 Sep;185(1):66-9 PMID: 22710390 SCOPUS ID: 2-s2.0-84864277999 06/20/2012       19 Citations
  • Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase. (Yu Z, Vodanovic-Jankovic S, Ledeboer N, Huang SX, Rajski SR, Kron M, Shen B) Org Lett 2011 Apr 15;13(8):2034-7 PMID: 21405052 PMCID: PMC3074013 SCOPUS ID: 2-s2.0-79955388062 03/17/2011       55 Citations
  • In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi. (Wenkert D, Ramirez B, Shen Y, Kron MA) J Parasitol Res 2010;2010:716498 PMID: 21253549 PMCID: PMC3021863 SCOPUS ID: 2-s2.0-79955413031 01/22/2011       11 Citations
  • A hybrid structural model of the complete Brugia malayi cytoplasmic asparaginyl-tRNA synthetase. (Crepin T, Peterson F, Haertlein M, Jensen D, Wang C, Cusack S, Kron M) J Mol Biol 2011 Jan 28;405(4):1056-69 PMID: 21134380 SCOPUS ID: 2-s2.0-79251595309 12/08/2010       32 Citations
  • Asparaginyl-tRNA synthetase pre-transfer editing assay. (Danel F, Caspers P, Nuoffer C, Härtlein M, Kron MA, Page MG) Curr Drug Discov Technol 2011 Mar;8(1):66-75 PMID: 21091430 SCOPUS ID: 2-s2.0-79951699053 11/26/2010       17 Citations
  • Crystallization and preliminary X-ray diffraction analysis of human cytosolic seryl-tRNA synthetase. (Artero JB, Teixeira SC, Mitchell EP, Kron MA, Forsyth VT, Haertlein M) Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Nov 01;66(Pt 11):1521-4 PMID: 21045311 PMCID: PMC3001664 SCOPUS ID: 2-s2.0-78149354812 11/04/2010       1 Citation
  • Using structural analysis to generate parasite-selective monoclonal antibodies. (Kron MA, Cichanowicz S, Hendrick A, Liu A, Leykam J, Kuhn LA) Protein Sci 2008 Jun;17(6):983-9 PMID: 18411421 PMCID: PMC2386738 SCOPUS ID: 2-s2.0-44349164577 04/16/2008       4 Citations
  • Interconversion between two unrelated protein folds in the lymphotactin native state. (Tuinstra RL, Peterson FC, Kutlesa S, Elgin ES, Kron MA, Volkman BF) Proc Natl Acad Sci U S A 2008 Apr 01;105(13):5057-62 PMID: 18364395 PMCID: PMC2278211 SCOPUS ID: 2-s2.0-42449084477 03/28/2008       224 Citations
  • Interconversion between two unrelated protein folds in the lymphotactin native state (Tuinstra R, Peterson F, Kutlesa S, Elgin ES, Kron M, Volkman B) Chemtracts March 2008;21(3):94-95 SCOPUS ID: 2-s2.0-58449127027 03/01/2008       2 Citations
  • Capacity building in anthelmintic drug discovery. (Kron M, Yousif F, Ramirez B) Expert Opin Drug Discov 2007 Oct;2(s1):S75-82 PMID: 23489035 SCOPUS ID: 2-s2.0-35348986947 10/01/2007       6 Citations
  • Identification of diadenosine triphosphate in Brugia malayi by reverse phase high performance liquid chromatography and MALDI mass spectrometry. (Kron M, Leykam J, Kopaczewski J, Matus I) J Chromatogr B Analyt Technol Biomed Life Sci 2007 Sep 01;856(1-2):234-8 PMID: 17631429 PMCID: PMC2044565 SCOPUS ID: 2-s2.0-34548126437 07/17/2007       9 Citations
  • Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change. (Sukuru SC, Crepin T, Milev Y, Marsh LC, Hill JB, Anderson RJ, Morris JC, Rohatgi A, O'Mahony G, Grøtli M, Danel F, Page MG, Härtlein M, Cusack S, Kron MA, Kuhn LA) J Comput Aided Mol Des 2006 Mar;20(3):159-78 PMID: 16645791 SCOPUS ID: 2-s2.0-33744488325 04/29/2006       45 Citations
  • Brugia malayi asparaginyl-transfer RNA synthetase induces chemotaxis of human leukocytes and activates G-protein-coupled receptors CXCR1 and CXCR2. (Ramirez BL, Howard OM, Dong HF, Edamatsu T, Gao P, Hartlein M, Kron M) J Infect Dis 2006 Apr 15;193(8):1164-71 PMID: 16544258 SCOPUS ID: 2-s2.0-33645783942 03/18/2006       28 Citations
  • Do tissue levels of autoantigenic aminoacyl-tRNA synthetase predict clinical disease? (Kron MA, Petridis M, Haertlein M, Libranda-Ramirez B, Scaffidi LE) Med Hypotheses 2005;65(6):1124-7 PMID: 16085368 SCOPUS ID: 2-s2.0-26444447921 08/09/2005       9 Citations
  • Synthesis and activity of substituted anthraquinones against a human filarial parasite, Brugia malayi. (Dhananjeyan MR, Milev YP, Kron MA, Nair MG) J Med Chem 2005 Apr 21;48(8):2822-30 PMID: 15828820 SCOPUS ID: 2-s2.0-17444392875 04/15/2005       65 Citations
  • Contrasting Wuchereria bancrofti microfilaria rates in two Mangyan-populated Philippine villages. (Ramirez BL, Hernandez L, Alberto FF, Collins M, Nfonsam V, Punsalan T, Kron MA) Am J Trop Med Hyg 2004 Jul;71(1):17-23 PMID: 15238683 SCOPUS ID: 2-s2.0-3142543140 07/09/2004       2 Citations
  • Genotypic characterization of Kaposi's sarcoma-associated herpesvirus in asymptomatic infected subjects from isolated populations. (Whitby D, Marshall VA, Bagni RK, Wang CD, Gamache CJ, Guzman JR, Kron M, Ebbesen P, Biggar RJ) J Gen Virol 2004 Jan;85(Pt 1):155-163 PMID: 14718630 SCOPUS ID: 2-s2.0-1642462856 01/14/2004       80 Citations
  • Expression, localization and alternative function of cytoplasmic asparaginyl-tRNA synthetase in Brugia malayi. (Kron M, Petridis M, Milev Y, Leykam J, Härtlein M) Mol Biochem Parasitol 2003 Jun;129(1):33-9 PMID: 12798504 SCOPUS ID: 2-s2.0-0038173767 06/12/2003       23 Citations
  • Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells. (Howard OM, Dong HF, Yang D, Raben N, Nagaraju K, Rosen A, Casciola-Rosen L, Härtlein M, Kron M, Yang D, Yiadom K, Dwivedi S, Plotz PH, Oppenheim JJ) J Exp Med 2002 Sep 16;196(6):781-91 PMID: 12235211 PMCID: PMC2194054 SCOPUS ID: 2-s2.0-0037120002 09/18/2002       237 Citations
  • Erratum: Human anti-asparaginyl-tRNA synthetase autoantibodies (anti-KS) increase the affinity of the enzyme for its tRNA substrate (FEBS Letters (2001) 494 (170-174) PII: S0014579301023407) (Beaulande M, Kron M, Hirakata M, Härtlein M) FEBS Letters 23 November 2001;508(3):493 SCOPUS ID: 2-s2.0-0035940999 11/23/2001       1 Citation
  • Human anti-asparaginyl-tRNA synthetase autoantibodies (anti-KS) increase the affinity of the enzyme for its tRNA substrate. (Beaulande M, Kron M, Hirakata M, Härtlein M) FEBS Lett 2001 Apr 13;494(3):170-4 PMID: 11311235 SCOPUS ID: 2-s2.0-0035853449 04/20/2001       12 Citations
  • Hyperimmunoglobulinemia E in the absence of atopy and filarial infection: the Huaorani of Ecuador. (Kron MA, Ammunariz M, Pandey J, Guzman JR) Allergy Asthma Proc 2000;21(6):335-41 PMID: 11191097 SCOPUS ID: 2-s2.0-0034330274 02/24/2001       11 Citations
  • Lymphatic filariasis in the Philippines. (Kron M, Walker E, Hernandez L, Torres E, Libranda-Ramirez B) Parasitol Today 2000 Aug;16(8):329-33 PMID: 10900480 SCOPUS ID: 2-s2.0-0034255790 07/20/2000       19 Citations
  • New molecular targets for filariasis drug discovery. (Lazdins J, Kron M) Parasitol Today 1999 Aug;15(8):305-6 PMID: 10407372 SCOPUS ID: 2-s2.0-0032806658 07/17/1999       21 Citations
  • Immunoglobulin allotypes among the Bicolanos of Sorsogon province, Luzon, Philippines: implications of phenotypes for filariasis. (Kron MA, Ramirez B, Belizario V Jr, Pandey JP) Exp Clin Immunogenet 1999;16(2):65-71 PMID: 10343157 SCOPUS ID: 2-s2.0-0032940169 05/27/1999       4 Citations
  • Anti-KS: identification of autoantibodies to asparaginyl-transfer RNA synthetase associated with interstitial lung disease. (Hirakata M, Suwa A, Nagai S, Kron MA, Trieu EP, Mimori T, Akizuki M, Targoff IN) J Immunol 1999 Feb 15;162(4):2315-20 PMID: 9973509 SCOPUS ID: 2-s2.0-0033558132 02/11/1999       164 Citations
  • Bartonellosis in Ecuador: serosurvey and current status of cutaneous verrucous disease. (Amano Y, Rumbea J, Knobloch J, Olson J, Kron M) Am J Trop Med Hyg 1997 Aug;57(2):174-9 PMID: 9288812 SCOPUS ID: 2-s2.0-0030852682 08/01/1997       42 Citations
  • The 75-kilodalton antigen of Bartonella bacilliformis is a structural homolog of the cell division protein FtsZ. (Padmalayam I, Anderson B, Kron M, Kelly T, Baumstark B) J Bacteriol 1997 Jul;179(14):4545-52 PMID: 9226264 PMCID: PMC179290 SCOPUS ID: 2-s2.0-0030811663 07/01/1997       20 Citations
  • Threat of dengue haemorrhagic fever after yellow fever vaccination. (Guzman JR, Kron MA) Lancet 1997 Jun 21;349(9068):1841 PMID: 9269239 SCOPUS ID: 2-s2.0-0030921371 06/21/1997       9 Citations
  • Substandard primaquine phosphate for US Peace Corps personnel. (Kron MA) Lancet 1996 Nov 23;348(9039):1453-4 PMID: 8937304 SCOPUS ID: 2-s2.0-0029854231 11/23/1996       16 Citations
  • Asparaginyl-trna synthetase of brugia malayi (Krön M, McMillan J) Journal of Investigative Medicine 1996;44(3) SCOPUS ID: 2-s2.0-33749428879 01/01/1996    
  • An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase. (Kron M, Marquard K, Härtlein M, Price S, Leberman R) FEBS Lett 1995 Oct 23;374(1):122-4 PMID: 7589498 SCOPUS ID: 2-s2.0-0028793421 10/23/1995       32 Citations
  • Infectious Disease in Ecuador. (Guzman JR, Jurado HM, Kron MA) J Travel Med 1995 Jun 01;2(2):89-95 PMID: 9815368 SCOPUS ID: 2-s2.0-84994912225 06/01/1995       4 Citations
  • Immunoglobulin allotypes in Ecuadorian Cayapa Indians. (Kron MA, Gately L, Pandey JP, Jurado MH, Rumbea Guzman J) Hum Genet 1994 May;93(5):517-9 PMID: 8168827 SCOPUS ID: 2-s2.0-0028177822 05/01/1994       2 Citations
  • Antibody responses to Onchocerca volvulus in Ecuadorian Indians and blacks. (Kron MA, Sisley B, Guderian RH, Mackenzie CD, Chico M, Jurado H, Rumbea Guzman J) Trop Med Parasitol 1993 Sep;44(3):152-4 PMID: 8256087 SCOPUS ID: 2-s2.0-0027364265 09/01/1993       7 Citations
  • Characterization of a variant tandem repeat from Sudanese Onchocerca volvulus. (Kron MA, Ali MH) Trop Med Parasitol 1993 Jun;44(2):113-5 PMID: 8367658 SCOPUS ID: 2-s2.0-0027196295 06/01/1993       4 Citations
  • Human infestation with Cochliomyia hominivorax, the New World screwworm. (Kron MA) J Am Acad Dermatol 1992 Aug;27(2 Pt 1):264-5 PMID: 1430370 SCOPUS ID: 2-s2.0-0026724541 08/01/1992       12 Citations
  • Characterization of a possible tRNA synthetase gene from Onchocerca volvulus. (Kron MA, Erttmann K, Greene BM, Unnasch T) Mol Biochem Parasitol 1992 Jun;52(2):289-92 PMID: 1620168 SCOPUS ID: 2-s2.0-0026554535 06/01/1992       4 Citations
  • Identification of related DNA sequences in Borrelia burgdorferi and two strains of Leptospira interrogans by using polymerase chain reaction. (Kron MA, Gupta A, Mackenzie CD) J Clin Microbiol 1991 Oct;29(10):2338-40 PMID: 1939594 PMCID: PMC270326 SCOPUS ID: 2-s2.0-0025949485 10/01/1991       2 Citations
  • Surface area calculation for Onchocerca volvulus microfilariae. (Kron MA, Mackenzie CD) Trop Med Parasitol 1991 Jun;42(2):151-2 PMID: 1896774 SCOPUS ID: 2-s2.0-0025875875 06/01/1991       1 Citation
  • Abdominal sparganosis in Ecuador: a case report. (Kron MA, Guderian R, Guevara A, Hidalgo A) Am J Trop Med Hyg 1991 Feb;44(2):146-50 PMID: 1826415 SCOPUS ID: 2-s2.0-0025847541 02/01/1991       15 Citations
  • OHIO-1 beta-lactamase is part of the SHV-1 family. (Shlaes DM, Currie-McCumber C, Hull A, Behlau I, Kron M) Antimicrob Agents Chemother 1990 Aug;34(8):1570-6 PMID: 2121093 PMCID: PMC171875 SCOPUS ID: 2-s2.0-0025030319 08/01/1990       22 Citations
  • Onchocerca volvulus recombinant antigen: physical characterization and clinical correlates with serum reactivity. (Gallin MY, Tan M, Kron MA, Rechnitzer D, Greene BM, Newland HS, White AT, Taylor HR, Unnasch TR) J Infect Dis 1989 Sep;160(3):521-9 PMID: 2760503 SCOPUS ID: 2-s2.0-0024410195 09/01/1989       26 Citations
  • Buffer's belly. (Kron MA, Ellner JJ) N Engl J Med 1988 Mar 03;318(9):584 PMID: 3340142 SCOPUS ID: 2-s2.0-0023845950 03/03/1988       4 Citations
  • Molecular epidemiology of OHIO-1 beta-lactamase. (Kron MA, Shlaes DM, Currie-McCumber C, Medeiros AA) Antimicrob Agents Chemother 1987 Dec;31(12):2007-9 PMID: 2830844 PMCID: PMC175845 SCOPUS ID: 2-s2.0-0023514404 12/01/1987       7 Citations
  • Severe onchocercal dermatitis in the Ethiopian border region of Sudan. (Ghalib HW, MacKenzie CD, Kron MA, Williams JF, el Khalifa M, el Sheikh H) Ann Trop Med Parasitol 1987 Aug;81(4):405-19 PMID: 3446029 SCOPUS ID: 2-s2.0-0023265180 08/01/1987       28 Citations
  • Cell adherence to microfilariae of Onchocerca volvulus: a comparative study. (Williams JF, Ghalib HW, Mackenzie CD, Elkhalifa MY, Ayuya JM, Kron MA) Ciba Found Symp 1987;127:146-63 PMID: 3595320 SCOPUS ID: 2-s2.0-0023065895 01/01/1987       16 Citations
  • Novel plasmid-mediated beta-lactamase in members of the family Enterobacteriaceae from Ohio. (Shlaes DM, Medeiros AA, Kron MA, Currie-McCumber C, Papa E, Vartian CV) Antimicrob Agents Chemother 1986 Aug;30(2):220-4 PMID: 3490215 PMCID: PMC180522 SCOPUS ID: 2-s2.0-0022459853 08/01/1986       19 Citations
  • Pentamidine: a review. (Sands M, Kron MA, Brown RB) Rev Infect Dis 1985;7(5):625-34 PMID: 3903942 SCOPUS ID: 2-s2.0-0022121314 09/01/1985       304 Citations
  • Clonorchiasis and praziquantel. (Hsu CC, Kron MA) Arch Intern Med 1985 Jun;145(6):1002-3 PMID: 4004423 SCOPUS ID: 2-s2.0-0021811417 06/01/1985    
  • Hepatitis A-induced remission of minimal change nephropathy. (Kron MA, Hedger R) Arch Intern Med 1984 Nov;144(11):2279-80 PMID: 6497535 SCOPUS ID: 2-s2.0-0021684286 11/01/1984       5 Citations
    • Last update: 06/11/2023