Faculty Collaboration Database

Acute Post-Concussive Assessments of Brain Tissue Magnetism Using Magnetic Resonance Imaging. J Neurotrauma 2021 Apr 01;38(7):848-857

Date

10/18/2020

Pubmed ID

33066712

Pubmed Central ID

PMC8432603

DOI

10.1089/neu.2020.7322

Scopus ID

2-s2.0-85103782270 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

Recent studies have demonstrated the promising capabilities of magnetic resonance imaging (MRI)-based quantitative susceptibility maps (QSM) in producing biomarkers of brain injury. The present study aims to further explore acute QSM changes in athletes after sports concussion and investigate prognostication capabilities of QSM-derived imaging metrics. The QSM were derived from neurological MRI data acquired on a cohort (n = 78) of concussed male American football athletes within 48 h of injury. The MRI-derived QSM values in subcortical gray and white matter compartments after concussion showed differences relative to a matched uninjured control group (white matter: z = 3.04, p = 0.002, subcortical gray matter: z = -2.07, p = 0.04). Subcortical gray matter QSM MRI measurements also correlated strongly with duration of symptoms (ρ = -0.46, p = 0.002) within a subcohort of subjects who had symptom durations for at least one week (n = 39). The acute QSM MRI metrics showed promising prognostication capabilities, with subcortical gray matter compartment QSM values yielding a mean classification area under the curve performance of 0.78 when predicting symptoms of more than two weeks in duration. The results of the study reproduce previous acute post-concussion group QSM findings and provide promising initial prognostication capabilities of acute QSM measurements in a post-concussion setting.

Author List

Koch KM, Nencka AS, Swearingen B, Bauer A, Meier TB, McCrea M

Authors

Kevin M. Koch PhD Center Director, Professor in the Radiology department at Medical College of Wisconsin
Michael McCrea PhD Professor in the Neurosurgery department at Medical College of Wisconsin
Timothy B. Meier PhD Associate Professor in the Neurosurgery department at Medical College of Wisconsin
Andrew S. Nencka PhD Director, Associate Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Brain
Brain Concussion
Cohort Studies
Football
Gray Matter
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Male
Prospective Studies
Schools
Universities
White Matter