Dual ALK and MYC rearrangements leading to an aggressive variant of anaplastic large cell lymphoma. J Pediatr Hematol Oncol 2013 Jul;35(5):e209-13
Date
04/27/2013Pubmed ID
23619105DOI
10.1097/MPH.0b013e3182815046Scopus ID
2-s2.0-84880315586 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
Anaplastic lymphoma kinase (ALK) and MYC are oncogenes often dysregulated in pediatric lymphomas. NPM-ALK/t(2;5)(p23;q35) is a genetic hallmark of ALK anaplastic large cell lymphoma (ALCL). MYC gene translocations are frequently detected in high-grade B-cell lymphomas. ALKALCL cases with concurrent MYC translocation are exceedingly rare and are more aggressive and chemoresistent compared with other ALKALCL. We report a patient who presented with ALKALCL possessing coexistent MYC rearrangement, massive tumor dissemination, and early widespread relapse. This case underscores the importance of recognition of close correlation between dual ALK and MYC rearrangements and the characteristic clinical features in this unusual ALCL variant.
Author List
Liang X, Branchford B, Greffe B, McGavran L, Carstens B, Meltesen L, Albano EA, Quinones R, Cook B, Graham DKAuthor
Brian Branchford MD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ChildGene Rearrangement
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lymphoma, Large-Cell, Anaplastic
Male
Oncogene Proteins, Fusion
Proto-Oncogene Proteins c-myc
Receptor Protein-Tyrosine Kinases
Translocation, Genetic
