Case report: renal phosphate wasting, syndrome of inappropriate antidiuretic hormone, and ectopic corticotropin production in small cell carcinoma. Am J Med Sci 1995 Jul;310(1):38-41
Date
07/01/1995Pubmed ID
7604839DOI
10.1097/00000441-199507000-00011Scopus ID
2-s2.0-0029020676 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
Renal phosphate wasting related to a tumor (oncogenous osteomalacia) is a rare disorder usually associated with benign mesenchymal tumors. In this article, the authors describe a man with renal phosphate wasting and the syndrome of inappropriate antidiuretic hormone associated with small cell carcinoma. Chemotherapy markedly reduced tumor burden and was associated with normalization of renal phosphate handling and serum sodium. With recurrence, renal phosphate wasting and the syndrome of inappropriate antidiuretic hormone developed again, with the additional complication of hypercortisolism secondary to ectopic corticotropin production. The authors report the rare occurrence of renal phosphate wasting with small cell carcinoma (5 previously reported cases) and the unique co-existence of this paraneoplastic syndrome with the syndrome of inappropriate antidiuretic hormone and ectopic corticotropin production.
Author List
Shaker JL, Brickner RC, Divgi AB, Raff H, Findling JWAuthors
James W. Findling MD Professor in the Medicine department at Medical College of WisconsinHershel Raff PhD Professor in the Academic Affairs department at Medical College of Wisconsin
Joseph L. Shaker MD Professor in the Medicine department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Adrenocorticotropic HormoneCarcinoma, Small Cell
Female
Humans
Inappropriate ADH Syndrome
Lung Neoplasms
Male
Middle Aged
Osteomalacia
