Generalization of a restraint-induced discriminative stimulus to cocaine in rats. Psychopharmacology (Berl) 1998 Feb;135(4):423-6
Date
04/16/1998Pubmed ID
9539268DOI
10.1007/s002130050531Scopus ID
2-s2.0-0031781198 (requires institutional sign-in at Scopus site) 34 CitationsAbstract
The ability of the interoceptive cues produced following exposure to restraint stress to generalize to the discriminative stimulus effects of cocaine was investigated. Rats were trained to discriminate cocaine (10 mg/kg, IP, n=10; or 20 mg/kg, IP, n=6) from saline using a two-choice, food-reinforced, drug discrimination design. Substitution for the 10 mg/kg training dose of cocaine was observed subsequent to exposure to 15 min of restraint when administered immediately following an injection of saline. Restraint-induced generalization in the 20 mg/kg training group was substantial, but not statistically significant. These data suggest that a component of the subjective effects of cocaine may be associated with "anxiety".
Author List
Mantsch JR, Goeders NEAuthor
John Mantsch PhD Chair, Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCocaine
Cues
Food
Generalization, Stimulus
Male
Narcotics
Rats
Rats, Wistar
Restraint, Physical
Stress, Psychological
