Medical College of Wisconsin
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John Mantsch PhD

John Mantsch PhD profile photo picture

Chair, Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Neuroscience Research Center


Publications (55)

  • Examining Opioid Overdose Deaths across Communities Defined by Racial Composition: a Multiscale Geographically Weighted Regression Approach. (Forati AM, Ghose R, Mantsch JR) J Urban Health 2021 08;98(4):551-562 PMID: 34231120 PMCID: PMC8260014 SCOPUS ID: 2-s2.0-85109316625 07/08/2021    
  • Estradiol Regulation of the Prelimbic Cortex and the Reinstatement of Cocaine Seeking in Female Rats. (Doncheck EM, Anderson EM, Konrath CD, Liddiard GT, DeBaker MC, Urbanik LA, Hearing MC, Mantsch JR) J Neurosci 2021 Jun 16;41(24):5303-5314 PMID: 33879537 PMCID: PMC8211550 SCOPUS ID: 2-s2.0-85108385872 04/22/2021    
  • Neurochemical mechanisms and neurocircuitry underlying the contribution of stress to cocaine seeking. (Caccamise A, Van Newenhizen E, Mantsch JR) J Neurochem 2021 06;157(5):1697-1713 PMID: 33660857 SCOPUS ID: 2-s2.0-85102848350 03/05/2021       1 Citation
  • Chronic Stress Prevents Cortico-Accumbens Cue Encoding and Alters Conditioned Approach. (Spring MG, Caccamise A, Panther EA, Windsor BM, Soni KR, McReynolds JR, Wheeler DS, Mantsch JR, Wheeler RA) J Neurosci 2021 03 17;41(11):2428-2436 PMID: 33622777 PMCID: PMC7984602 SCOPUS ID: 2-s2.0-85103113272 02/25/2021    
  • Sex, stress, and prefrontal cortex: influence of biological sex on stress-promoted cocaine seeking. (Doncheck EM, Liddiard GT, Konrath CD, Liu X, Yu L, Urbanik LA, Herbst MR, DeBaker MC, Raddatz N, Van Newenhizen EC, Mathy J, Gilmartin MR, Liu QS, Hillard CJ, Mantsch JR) Neuropsychopharmacology 2020 11;45(12):1974-1985 PMID: 32303052 PMCID: PMC7547655 SCOPUS ID: 2-s2.0-85084141235 04/18/2020       9 Citations
  • What does the Fos say? Using Fos-based approaches to understand the contribution of stress to substance use disorders. (McReynolds JR, Christianson JP, Blacktop JM, Mantsch JR) Neurobiol Stress 2018 Nov;9:271-285 PMID: 30450391 PMCID: PMC6234265 SCOPUS ID: 2-s2.0-85048550841 11/20/2018       16 Citations
  • Enhanced CRFR1-Dependent Regulation of a Ventral Tegmental Area to Prelimbic Cortex Projection Establishes Susceptibility to Stress-Induced Cocaine Seeking. (Vranjkovic O, Van Newenhizen EC, Nordness ME, Blacktop JM, Urbanik LA, Mathy JC, McReynolds JR, Miller AM, Doncheck EM, Kloehn TM, Stinnett GS, Gerndt CH, Ketchesin KD, Baker DA, Seasholtz AF, Mantsch JR) J Neurosci 2018 12 12;38(50):10657-10671 PMID: 30355627 PMCID: PMC6290294 SCOPUS ID: 2-s2.0-85058598503 10/26/2018       6 Citations
  • Kappa counterconditioning of cocaine cues. (Mantsch JR, Twining RC) Neuropsychopharmacology 2018 06;43(7):1469-1470 PMID: 29559727 PMCID: PMC5983536 SCOPUS ID: 2-s2.0-85044212497 03/22/2018    
  • Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex. (McReynolds JR, Doncheck EM, Li Y, Vranjkovic O, Graf EN, Ogasawara D, Cravatt BF, Baker DA, Liu QS, Hillard CJ, Mantsch JR) Biol Psychiatry 2018 07 15;84(2):85-94 PMID: 29100630 PMCID: PMC5889367 SCOPUS ID: 2-s2.0-85033680278 11/05/2017       17 Citations
  • Corticosterone regulates both naturally occurring and cocaine-induced dopamine signaling by selectively decreasing dopamine uptake. (Wheeler DS, Ebben AL, Kurtoglu B, Lovell ME, Bohn AT, Jasek IA, Baker DA, Mantsch JR, Gasser PJ, Wheeler RA) Eur J Neurosci 2017 Nov;46(10):2638-2646 PMID: 28965353 PMCID: PMC5704943 SCOPUS ID: 2-s2.0-85032881401 10/02/2017       20 Citations
  • 17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors. (Doncheck EM, Urbanik LA, DeBaker MC, Barron LM, Liddiard GT, Tuscher JJ, Frick KM, Hillard CJ, Mantsch JR) Neuropsychopharmacology 2018 03;43(4):781-790 PMID: 28825421 PMCID: PMC5809785 SCOPUS ID: 2-s2.0-85041731033 08/22/2017       16 Citations
  • Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3. (McReynolds JR, Taylor A, Vranjkovic O, Ambrosius T, Derricks O, Nino B, Kurtoglu B, Wheeler RA, Baker DA, Gasser PJ, Mantsch JR) Neuropsychopharmacology 2017 02;42(3):757-765 PMID: 27604564 PMCID: PMC5240184 SCOPUS ID: 2-s2.0-84990940925 09/09/2016       13 Citations
  • Pituitary Adenylate cyclase-activating polypeptide orchestrates neuronal regulation of the astrocytic glutamate-releasing mechanism system xc (.). (Kong L, Albano R, Madayag A, Raddatz N, Mantsch JR, Choi S, Lobner D, Baker DA) J Neurochem 2016 May;137(3):384-93 PMID: 26851652 PMCID: PMC4878137 SCOPUS ID: 2-s2.0-84963626414 02/07/2016       8 Citations
  • Antagonism of GABA-B but not GABA-A receptors in the VTA prevents stress- and intra-VTA CRF-induced reinstatement of extinguished cocaine seeking in rats. (Blacktop JM, Vranjkovic O, Mayer M, Van Hoof M, Baker DA, Mantsch JR) Neuropharmacology 2016 Mar;102:197-206 PMID: 26596556 PMCID: PMC4717150 SCOPUS ID: 2-s2.0-84948467099 11/26/2015       10 Citations
  • CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats. (McReynolds JR, Doncheck EM, Vranjkovic O, Ganzman GS, Baker DA, Hillard CJ, Mantsch JR) Psychopharmacology (Berl) 2016 Jan;233(1):99-109 PMID: 26455361 PMCID: PMC4703460 SCOPUS ID: 2-s2.0-84953275278 10/13/2015       25 Citations
  • Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress. (Mantsch JR, Baker DA, Funk D, Lê AD, Shaham Y) Neuropsychopharmacology 2016 Jan;41(1):335-56 PMID: 25976297 PMCID: PMC4677117 SCOPUS ID: 2-s2.0-84949546435 05/16/2015       225 Citations
  • Aversive stimuli drive drug seeking in a state of low dopamine tone. (Twining RC, Wheeler DS, Ebben AL, Jacobsen AJ, Robble MA, Mantsch JR, Wheeler RA) Biol Psychiatry 2015 May 15;77(10):895-902 PMID: 25442790 PMCID: PMC4369463 SCOPUS ID: 2-s2.0-84928727111 12/03/2014       30 Citations
  • Stress-induced cocaine seeking requires a beta-2 adrenergic receptor-regulated pathway from the ventral bed nucleus of the stria terminalis that regulates CRF actions in the ventral tegmental area. (Vranjkovic O, Gasser PJ, Gerndt CH, Baker DA, Mantsch JR) J Neurosci 2014 Sep 10;34(37):12504-14 PMID: 25209288 PMCID: PMC4160780 SCOPUS ID: 2-s2.0-84907008503 09/12/2014       50 Citations
  • Behavioral assessment of acute inhibition of system xc (-) in rats. (Lutgen V, Resch J, Qualmann K, Raddatz NJ, Panhans C, Olander EM, Kong L, Choi S, Mantsch JR, Baker DA) Psychopharmacology (Berl) 2014 Dec;231(24):4637-47 PMID: 24828877 PMCID: PMC4474164 SCOPUS ID: 2-s2.0-84922065729 05/16/2014       12 Citations
  • Beta-2 adrenergic receptors mediate stress-evoked reinstatement of cocaine-induced conditioned place preference and increases in CRF mRNA in the bed nucleus of the stria terminalis in mice. (McReynolds JR, Vranjkovic O, Thao M, Baker DA, Makky K, Lim Y, Mantsch JR) Psychopharmacology (Berl) 2014 Oct;231(20):3953-63 PMID: 24696080 SCOPUS ID: 2-s2.0-84897264774 04/04/2014       27 Citations
  • Neurobiological mechanisms underlying relapse to cocaine use: contributions of CRF and noradrenergic systems and regulation by glucocorticoids. (McReynolds JR, Peña DF, Blacktop JM, Mantsch JR) Stress 2014 Jan;17(1):22-38 PMID: 24328808 SCOPUS ID: 2-s2.0-84890909066 12/18/2013       26 Citations
  • Neurobiological mechanisms that contribute to stress-related cocaine use. (Mantsch JR, Vranjkovic O, Twining RC, Gasser PJ, McReynolds JR, Blacktop JM) Neuropharmacology 2014 Jan;76 Pt B:383-94 PMID: 23916481 PMCID: PMC3859518 SCOPUS ID: 2-s2.0-84887070236 08/07/2013       40 Citations
  • Corticosterone acts in the nucleus accumbens to enhance dopamine signaling and potentiate reinstatement of cocaine seeking. (Graf EN, Wheeler RA, Baker DA, Ebben AL, Hill JE, McReynolds JR, Robble MA, Vranjkovic O, Wheeler DS, Mantsch JR, Gasser PJ) J Neurosci 2013 Jul 17;33(29):11800-10 PMID: 23864669 PMCID: PMC3713722 SCOPUS ID: 2-s2.0-84880429231 07/19/2013       92 Citations
  • Time course of cocaine-induced behavioral and neurochemical plasticity. (Lutgen V, Kong L, Kau KS, Madayag A, Mantsch JR, Baker DA) Addict Biol 2014 Jul;19(4):529-38 PMID: 22970924 PMCID: PMC3525779 SCOPUS ID: 2-s2.0-84904267961 09/14/2012       11 Citations
  • β-adrenergic receptor mediation of stress-induced reinstatement of extinguished cocaine-induced conditioned place preference in mice: roles for β1 and β2 adrenergic receptors. (Vranjkovic O, Hang S, Baker DA, Mantsch JR) J Pharmacol Exp Ther 2012 Aug;342(2):541-51 PMID: 22593095 PMCID: PMC3400797 SCOPUS ID: 2-s2.0-84864121632 05/18/2012       41 Citations
  • l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction. (Wang JB, Mantsch JR) Future Med Chem 2012 Feb;4(2):177-86 PMID: 22300097 PMCID: PMC3878639 SCOPUS ID: 2-s2.0-84863011788 02/04/2012       69 Citations
  • Cannabinoid receptor involvement in stress-induced cocaine reinstatement: potential interaction with noradrenergic pathways. (Vaughn LK, Mantsch JR, Vranjkovic O, Stroh G, Lacourt M, Kreutter M, Hillard CJ) Neuroscience 2012 Mar 01;204:117-24 PMID: 21871539 PMCID: PMC3422566 SCOPUS ID: 2-s2.0-84857125721 08/30/2011       31 Citations
  • Glutamatergic plasticity in medial prefrontal cortex and ventral tegmental area following extended-access cocaine self-administration. (Ghasemzadeh MB, Vasudevan P, Giles C, Purgianto A, Seubert C, Mantsch JR) Brain Res 2011 Sep 21;1413:60-71 PMID: 21855055 PMCID: PMC4000163 SCOPUS ID: 2-s2.0-80052443440 08/23/2011       38 Citations
  • Augmented cocaine seeking in response to stress or CRF delivered into the ventral tegmental area following long-access self-administration is mediated by CRF receptor type 1 but not CRF receptor type 2. (Blacktop JM, Seubert C, Baker DA, Ferda N, Lee G, Graf EN, Mantsch JR) J Neurosci 2011 Aug 03;31(31):11396-403 PMID: 21813699 PMCID: PMC3449095 SCOPUS ID: 2-s2.0-79961236775 08/05/2011       76 Citations
  • Adrenal activity during repeated long-access cocaine self-administration is required for later CRF-Induced and CRF-dependent stressor-induced reinstatement in rats. (Graf EN, Hoks MA, Baumgardner J, Sierra J, Vranjkovic O, Bohr C, Baker DA, Mantsch JR) Neuropsychopharmacology 2011 Jun;36(7):1444-54 PMID: 21412222 PMCID: PMC3096813 SCOPUS ID: 2-s2.0-79956020911 03/18/2011       22 Citations
  • Oral administration of levo-tetrahydropalmatine attenuates reinstatement of extinguished cocaine seeking by cocaine, stress or drug-associated cues in rats. (Figueroa-Guzman Y, Mueller C, Vranjkovic O, Wisniewski S, Yang Z, Li SJ, Bohr C, Graf EN, Baker DA, Mantsch JR) Drug Alcohol Depend 2011 Jul 01;116(1-3):72-9 PMID: 21196089 PMCID: PMC3466100 SCOPUS ID: 2-s2.0-79957593608 01/05/2011       37 Citations
  • Repeated N-acetyl cysteine reduces cocaine seeking in rodents and craving in cocaine-dependent humans. (Amen SL, Piacentine LB, Ahmad ME, Li SJ, Mantsch JR, Risinger RC, Baker DA) Neuropsychopharmacology 2011 Mar;36(4):871-8 PMID: 21160464 PMCID: PMC3052624 SCOPUS ID: 2-s2.0-79951508231 12/17/2010       107 Citations
  • Levo-tetrahydropalmatine attenuates cocaine self-administration under a progressive-ratio schedule and cocaine discrimination in rats. (Mantsch JR, Wisniewski S, Vranjkovic O, Peters C, Becker A, Valentine A, Li SJ, Baker DA, Yang Z) Pharmacol Biochem Behav 2010 Dec;97(2):310-6 PMID: 20816889 PMCID: PMC2956862 SCOPUS ID: 2-s2.0-77957811262 09/08/2010       35 Citations
  • Involvement of noradrenergic neurotransmission in the stress- but not cocaine-induced reinstatement of extinguished cocaine-induced conditioned place preference in mice: role for β-2 adrenergic receptors. (Mantsch JR, Weyer A, Vranjkovic O, Beyer CE, Baker DA, Caretta H) Neuropsychopharmacology 2010 Oct;35(11):2165-78 PMID: 20613718 PMCID: PMC2939933 SCOPUS ID: 2-s2.0-78651301305 07/09/2010       91 Citations
  • Drug-induced plasticity contributing to heightened relapse susceptibility: neurochemical changes and augmented reinstatement in high-intake rats. (Madayag A, Kau KS, Lobner D, Mantsch JR, Wisniewski S, Baker DA) J Neurosci 2010 Jan 06;30(1):210-7 PMID: 20053903 PMCID: PMC2823262 SCOPUS ID: 2-s2.0-74849106113 01/08/2010       24 Citations
  • Region-specific alterations in glutamate receptor expression and subcellular distribution following extinction of cocaine self-administration. (Ghasemzadeh MB, Vasudevan P, Mueller CR, Seubert C, Mantsch JR) Brain Res 2009 Apr 24;1267:89-102 PMID: 19368820 SCOPUS ID: 2-s2.0-63449104933 04/17/2009       49 Citations
  • Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self-administration. (Ghasemzadeh MB, Vasudevan P, Mueller C, Seubert C, Mantsch JR) Neurosci Lett 2009 Mar 13;452(2):167-71 PMID: 19118598 PMCID: PMC3824377 SCOPUS ID: 2-s2.0-60249091229 01/03/2009       47 Citations
  • Blunted cystine-glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seeking. (Kau KS, Madayag A, Mantsch JR, Grier MD, Abdulhameed O, Baker DA) Neuroscience 2008 Aug 13;155(2):530-7 PMID: 18601982 PMCID: PMC2614296 SCOPUS ID: 2-s2.0-49349104661 07/08/2008       86 Citations
  • Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine. (Madayag A, Lobner D, Kau KS, Mantsch JR, Abdulhameed O, Hearing M, Grier MD, Baker DA) J Neurosci 2007 Dec 19;27(51):13968-76 PMID: 18094234 PMCID: PMC2996827 SCOPUS ID: 2-s2.0-38449086396 12/21/2007       177 Citations
  • Stressor- and corticotropin releasing factor-induced reinstatement and active stress-related behavioral responses are augmented following long-access cocaine self-administration by rats. (Mantsch JR, Baker DA, Francis DM, Katz ES, Hoks MA, Serge JP) Psychopharmacology (Berl) 2008 Jan;195(4):591-603 PMID: 17899015 PMCID: PMC3888801 SCOPUS ID: 2-s2.0-36348984553 09/28/2007       78 Citations
  • Daily cocaine self-administration under long-access conditions augments restraint-induced increases in plasma corticosterone and impairs glucocorticoid receptor-mediated negative feedback in rats. (Mantsch JR, Cullinan WE, Tang LC, Baker DA, Katz ES, Hoks MA, Ziegler DR) Brain Res 2007 Sep 05;1167:101-11 PMID: 17689506 PMCID: PMC2121305 SCOPUS ID: 2-s2.0-34548133391 08/11/2007       44 Citations
  • Surgical adrenalectomy with diurnal corticosterone replacement slows escalation and prevents the augmentation of cocaine-induced reinstatement in rats self-administering cocaine under long-access conditions. (Mantsch JR, Baker DA, Serge JP, Hoks MA, Francis DM, Katz ES) Neuropsychopharmacology 2008 Mar;33(4):814-26 PMID: 17534378 SCOPUS ID: 2-s2.0-39149108447 05/31/2007       28 Citations
  • Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats. (Mantsch JR, Li SJ, Risinger R, Awad S, Katz E, Baker DA, Yang Z) Psychopharmacology (Berl) 2007 Jul;192(4):581-91 PMID: 17361394 SCOPUS ID: 2-s2.0-34249869292 03/16/2007       80 Citations
  • Restraint-induced corticosterone secretion and hypothalamic CRH mRNA expression are augmented during acute withdrawal from chronic cocaine administration. (Mantsch JR, Taves S, Khan T, Katz ES, Sajan T, Tang LC, Cullinan WE, Ziegler DR) Neurosci Lett 2007 Mar 30;415(3):269-73 PMID: 17293045 PMCID: PMC1978484 SCOPUS ID: 2-s2.0-33947162167 02/13/2007       26 Citations
  • Elevation of glucocorticoids is necessary but not sufficient for the escalation of cocaine self-administration by chronic electric footshock stress in rats. (Mantsch JR, Katz ES) Neuropsychopharmacology 2007 Feb;32(2):367-76 PMID: 16641943 SCOPUS ID: 2-s2.0-33846234293 04/28/2006       44 Citations
  • Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. (Mantsch JR, Yuferov V, Mathieu-Kia AM, Ho A, Kreek MJ) Psychopharmacology (Berl) 2004 Aug;175(1):26-36 PMID: 15042275 SCOPUS ID: 2-s2.0-4544255012 03/26/2004       161 Citations
  • Neuroendocrine alterations in a high-dose, extended-access rat self-administration model of escalating cocaine use. (Mantsch JR, Yuferov V, Mathieu-Kia AM, Ho A, Kreek MJ) Psychoneuroendocrinology 2003 Oct;28(7):836-62 PMID: 12892653 SCOPUS ID: 2-s2.0-0042700149 08/02/2003       48 Citations
  • Conditioned place preference after single doses or "binge" cocaine in C57BL/6J and 129/J mice. (Zhang Y, Mantsch JR, Schlussman SD, Ho A, Kreek MJ) Pharmacol Biochem Behav 2002 Oct;73(3):655-62 PMID: 12151041 08/02/2002    
  • Predictable individual differences in the initiation of cocaine self-administration by rats under extended-access conditions are dose-dependent. (Mantsch JR, Ho A, Schlussman SD, Kreek MJ) Psychopharmacology (Berl) 2001 Aug;157(1):31-9 PMID: 11512040 SCOPUS ID: 2-s2.0-0034879420 08/21/2001       136 Citations
  • Effects of cocaine self-administration on plasma corticosterone in rats: relationship to hippocampal type II glucocorticoid receptors. (Mantsch JR, Goeders NE) Prog Neuropsychopharmacol Biol Psychiatry 2000 May;24(4):633-46 PMID: 10958156 SCOPUS ID: 2-s2.0-0034190491 08/25/2000       21 Citations
  • Effects of cocaine self-administration on plasma corticosterone and prolactin in rats. (Mantsch JR, Schlussman SD, Ho A, Kreek MJ) J Pharmacol Exp Ther 2000 Jul;294(1):239-47 PMID: 10871318 SCOPUS ID: 2-s2.0-0033917937 06/28/2000       51 Citations
  • Ketoconazole does not block cocaine discrimination or the cocaine-induced reinstatement of cocaine-seeking behavior. (Mantsch JR, Goeders NE) Pharmacol Biochem Behav 1999 Sep;64(1):65-73 PMID: 10494999 SCOPUS ID: 2-s2.0-0032835215 09/24/1999       40 Citations
  • Ketoconazole blocks the stress-induced reinstatement of cocaine-seeking behavior in rats: relationship to the discriminative stimulus effects of cocaine. (Mantsch JR, Goeders NE) Psychopharmacology (Berl) 1999 Mar;142(4):399-407 PMID: 10229065 SCOPUS ID: 2-s2.0-0032893173 05/06/1999       93 Citations
  • Corticosterone facilitates the acquisition of cocaine self-administration in rats: opposite effects of the type II glucocorticoid receptor agonist dexamethasone. (Mantsch JR, Saphier D, Goeders NE) J Pharmacol Exp Ther 1998 Oct;287(1):72-80 PMID: 9765324 SCOPUS ID: 2-s2.0-0032463958 10/09/1998       98 Citations
  • Generalization of a restraint-induced discriminative stimulus to cocaine in rats. (Mantsch JR, Goeders NE) Psychopharmacology (Berl) 1998 Feb;135(4):423-6 PMID: 9539268 SCOPUS ID: 2-s2.0-0031781198 04/16/1998       33 Citations
  • Last update: 07/09/2021