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Risk of Venous Thromboembolism in Acute Necrotizing Pancreatitis: A Large Database Study. Pancreas 2021 Jan 01;50(1):71-76

Date

12/29/2020

Pubmed ID

33370025

DOI

10.1097/MPA.0000000000001714

Scopus ID

2-s2.0-85098148082   1 Citation

Abstract

OBJECTIVES: Studies on the incidence of venous thromboembolism (VTE) in acute pancreatitis (AP) are scarce. We conducted a large database study to evaluate this relationship.

METHODS: Data were extracted from a large electronic health record (Explorys; IBM Watson Health, Armonk, NY). We identified patients with AP in 2018 and 2019, analyzing VTE incidence at 30 days after diagnosis of AP. Univariate and multivariate analyses were performed to identify risk factors associated with VTE.

RESULTS: A total of 25,620 cases of acute necrotizing pancreatitis (ANP) and 155,800 cases of acute nonnecrotizing pancreatitis (ANNP) were identified. The incidence of VTE was 7.1% for ANP, compared with 2.8% in ANNP (P < 0.001). On multivariate analysis, ANP conferred significantly greater odds of VTE (adjusted odds ratio, 2.78; 95% confidence interval, 2.73-2.84; P < 0.001), independent of other variables. In those with ANP, the presence of VTE was associated with a significantly higher mortality (23.5% vs 15.9%, P < 0.001).

CONCLUSIONS: Acute necrotizing pancreatitis carries near 2.5-fold risk of VTE, and a 3-fold risk of PE, compared with those with ANNP. Venous thromboembolism development in ANP is associated with higher mortality.

Author List

Ahmad DS, Mansoor E, Alikhan MM, Rana MN, Panhwar MS, Wong RCK, Smith ZL

Author

Zachary Smith DO Associate Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Comorbidity
Cross-Sectional Studies
Databases, Factual
Electronic Health Records
Female
Humans
Incidence
Male
Middle Aged
Pancreatitis, Acute Necrotizing
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
United States
Venous Thromboembolism
Young Adult