Auditory brainstem responses in aging dark agouti rats. Biosci Rep 2021 Feb 26;41(2)
Date
01/29/2021Pubmed ID
33506259Pubmed Central ID
PMC7897922DOI
10.1042/BSR20202724Scopus ID
2-s2.0-85102217469 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
The present study examined auditory function across age in the dark agouti (DA) rat strain. Auditory brainstem responses (ABRs) were measured for frequencies 8, 16, and 32 kHz in male and female DA rats from 3 to 18 months of age. Hearing thresholds and absolute and interpeak latencies (IPLs) were analyzed. Male hearing thresholds remained stable for the first year of life and then significantly increased at 18 months across all frequencies; female hearing remained stable at all tested ages out to 18 months. At 12 months, male DA rats showed significantly longer absolute latencies by age (i.e., compared with 3-month-old males) and sex (compared with 12-month-old females), with no differences in IPLs. At 18 months, female DA rats showed significantly longer absolute latencies with age (compared with 3-month-old females) and sex (compared with 18-month-old males), particularly for the later waves. Female IPLs were also significantly longer with age and by sex for the later waves. This report supports the feasibility of using male DA rats in studies to investigate age-related hearing loss (ARHL; presbycusis).
Author List
Beltrame AK, Dahms NM, Runge CLAuthors
Nancy M. Dahms PhD Professor in the Biochemistry department at Medical College of WisconsinChristina Runge PhD Associate Provost, Chief, Professor in the Otolaryngology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsAuditory Threshold
Brain Stem
Cochlea
Cross-Sectional Studies
Disease Models, Animal
Evoked Potentials, Auditory, Brain Stem
Female
Male
Presbycusis
Rats
Reaction Time
