Apoptosis in the initiation, modulation and termination of the corneal wound healing response. Exp Eye Res 2007 Sep;85(3):305-11
Date
07/28/2007Pubmed ID
17655845Pubmed Central ID
PMC2039895DOI
10.1016/j.exer.2007.06.009Scopus ID
2-s2.0-34547856274 (requires institutional sign-in at Scopus site) 134 CitationsAbstract
Stromal keratocyte apoptosis has been well-characterized as an early initiating event of the corneal wound healing response, triggering subsequent cellular processes that include bone marrow-derived cell infiltration, proliferation and migration of residual keratocyte cells, and, in some circumstances, generation of myofibroblast cells. Recent studies, however, have suggested a more general role for apoptosis in the overall stromal wound healing response that includes modulation and termination functions. This review article highlights, and ties together, recent studies that have demonstrated the important role apoptosis likely plays in weeks to months following an initial insult to the cornea-depending on the type and extent of corneal injury.
Author List
Wilson SE, Chaurasia SS, Medeiros FWAuthor
Shyam S. Chaurasia PhD Associate Professor in the Ophthalmology and Visual Sciences department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsApoptosis
Bone Marrow Cells
Cornea
Corneal Injuries
Corneal Stroma
Humans
Necrosis
Time Factors
Wound Healing
