Faculty Collaboration Database

Withania somnifera root extract in the regulation of lead-induced oxidative damage in male mouse. Pharmacol Res 2000 Jun;41(6):663-6

Date

05/19/2000

Pubmed ID

10816336

DOI

10.1006/phrs.1999.0634

Scopus ID

2-s2.0-0033840501 (requires institutional sign-in at Scopus site)   49 Citations

Abstract

The importance of Withania somnifera root extract in the regulation of lead toxicity with special reference to lipid peroxidative process has been investigated in liver and kidney tissues. While lead treatment (0.5 mg kg(-1)body wt. day(-1)for 20 days) enhanced hepatic and renal lipid peroxidation (LPO), administration of plant extract in the doses of 0.7 g kg(-1)and 1.4 g kg(-1)body wt. day(-1)along with equivalent doses of lead acetate for 20 days significantly decreased LPO and increased the activities of antioxidant enzymes, viz., superoxide dismutase (SOD) and catalase (CAT), thus retaining normal peroxidative status of the tissues. We suggest that the ameliorating role of root extract of W. somnifera in the lead intoxicated mice could be the result of its antiperoxidative action.

Author List

Chaurasia SS, Panda S, Kar A

Author

Shyam S. Chaurasia PhD Associate Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Catalase
Kidney
Lead
Lipid Peroxidation
Liver
Male
Mice
Plant Extracts
Solanaceae
Superoxide Dismutase