Faculty Collaboration Database

Clinical Spectrum and Outcomes of Neonatal Necrotizing Enterocolitis. In Vivo 2021;35(1):585-591

Date

01/07/2021

Pubmed ID

33402513

Pubmed Central ID

PMC7880741

DOI

10.21873/invivo.12295

Scopus ID

2-s2.0-85099424503 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

BACKGROUND/AIM: The objective of the study was analysis of risk factors associated with outcome of necrotizing enterocolitis (NEC) in infants in a single-center study.

PATIENTS AND METHODS: All consecutive infants hospitalized for NEC over a period of 6 years were retrospectively analyzed for clinical course, infections, treatment and outcome.

RESULTS: Out of 76 patients, surgical management was applied in 56 (53 exploratory laparotomy, three initial peritoneal drain placement) and in 20 there was only a conservative approach. Segmental intestinal resection was performed in 41 patients. Survival from NEC in our cohort was 79%. We found that independent adverse risk factors of outcome of newborns and infants with NEC were gut perforation, infection, abdominal wall erythema, and development of acute kidney injury.

CONCLUSION: We underline the value of both surgical and conservative approach with careful management in this cohort of patients.

Author List

GaŁĄzka P, Chrzanowska M, StyczyŃski J

Author

Magdalena Chrzanowska PhD Associate Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Drainage
Enterocolitis, Necrotizing
Humans
Infant
Infant, Newborn
Intestinal Perforation
Laparotomy
Retrospective Studies