Medical College of Wisconsin
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Magdalena Chrzanowska PhD

Magdalena Chrzanowska PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Cancer Center
Member of the Cardiovascular Center

Publications (25)

  • Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier. (Lakshmikanthan S, Sobczak M, Li Calzi S, Shaw L, Grant MB, Chrzanowska-Wodnicka M) J Cell Sci 2018 01 10;131(1) PMID: 29222111 PMCID: PMC5818062 12/10/2017       10 Citations
  • Rap1b Is an Effector of Axin2 Regulating Crosstalk of Signaling Pathways During Skeletal Development. (Maruyama T, Jiang M, Abbott A, Yu HI, Huang Q, Chrzanowska-Wodnicka M, Chen EI, Hsu W) J Bone Miner Res 2017 Sep;32(9):1816-1828 PMID: 28520221 PMCID: PMC5555789 05/19/2017       7 Citations
  • Rap1 in endothelial biology. (Chrzanowska-Wodnicka M) Curr Opin Hematol 2017 May;24(3):248-255 PMID: 28178039 PMCID: PMC5920548 02/09/2017       16 Citations
  • Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization. (Wang H, Han X, Bretz CA, Becker S, Gambhir D, Smith GW, Samulski RJ, Wittchen ES, Quilliam LA, Chrzanowska-Wodnicka M, Hartnett ME) Mol Ther Methods Clin Dev 2016;3:16056 PMID: 27606349 PMCID: PMC4996131 09/09/2016    
  • Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice. (Rana U, Liu Z, Kumar SN, Zhao B, Hu W, Bordas M, Cossette S, Szabo S, Foeckler J, Weiler H, Chrzanowska-Wodnicka M, Holtz ML, Misra RP, Salato V, North PE, Ramchandran R, Miao QR) Dev Biol 2016 Feb 15;410(2):190-201 PMID: 26746789 PMCID: PMC4767500 SCOPUS ID: 2-s2.0-84957847497 01/10/2016       13 Citations
  • Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature. (Chrzanowska-Wodnicka M, White GC 2nd, Quilliam LA, Whitehead KJ) PLoS One 2015;10(12):e0145689 PMID: 26714318 PMCID: PMC4694701 12/30/2015       17 Citations
  • Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function. (Lakshmikanthan S, Zheng X, Nishijima Y, Sobczak M, Szabo A, Vasquez-Vivar J, Zhang DX, Chrzanowska-Wodnicka M) EMBO Rep 2015 May;16(5):628-37 PMID: 25807985 PMCID: PMC4428051 SCOPUS ID: 2-s2.0-84928885238 03/27/2015       23 Citations
  • The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation. (Kumar S, Xu J, Kumar RS, Lakshmikanthan S, Kapur R, Kofron M, Chrzanowska-Wodnicka M, Filippi MD) J Exp Med 2014 Aug 25;211(9):1741-58 PMID: 25092872 PMCID: PMC4144729 08/06/2014       37 Citations
  • Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure. (Lakshmikanthan S, Zieba BJ, Ge ZD, Momotani K, Zheng X, Lund H, Artamonov MV, Maas JE, Szabo A, Zhang DX, Auchampach JA, Mattson DL, Somlyo AV, Chrzanowska-Wodnicka M) Arterioscler Thromb Vasc Biol 2014 Jul;34(7):1486-94 PMID: 24790136 PMCID: PMC4224284 SCOPUS ID: 2-s2.0-84903159007 05/03/2014       27 Citations
  • Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization. (Wang H, Jiang Y, Shi D, Quilliam LA, Chrzanowska-Wodnicka M, Wittchen ES, Li DY, Hartnett ME) FASEB J 2014 Jan;28(1):265-74 PMID: 24043260 PMCID: PMC3868836 09/18/2013       13 Citations
  • Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo. (Wittchen ES, Nishimura E, McCloskey M, Wang H, Quilliam LA, Chrzanowska-Wodnicka M, Hartnett ME) PLoS One 2013;8(9):e73070 PMID: 24039860 PMCID: PMC3769400 09/17/2013       22 Citations
  • Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction. (Chrzanowska-Wodnicka M) Exp Cell Res 2013 Sep 10;319(15):2350-9 PMID: 23911990 PMCID: PMC3913003 08/06/2013    
  • Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling. (Zhang G, Xiang B, Ye S, Chrzanowska-Wodnicka M, Morris AJ, Gartner TK, Whiteheart SW, White GC 2nd, Smyth SS, Li Z) J Biol Chem 2011 Nov 11;286(45):39466-77 PMID: 21940635 PMCID: PMC3234770 09/24/2011       47 Citations
  • Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃. (Lakshmikanthan S, Sobczak M, Chun C, Henschel A, Dargatz J, Ramchandran R, Chrzanowska-Wodnicka M) Blood 2011 Aug 18;118(7):2015-26 PMID: 21636859 PMCID: PMC3158727 06/04/2011       65 Citations
  • The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity. (Zieba BJ, Artamonov MV, Jin L, Momotani K, Ho R, Franke AS, Neppl RL, Stevenson AS, Khromov AS, Chrzanowska-Wodnicka M, Somlyo AV) J Biol Chem 2011 May 13;286(19):16681-92 PMID: 21454546 PMCID: PMC3089510 04/02/2011       68 Citations
  • Isolation and culture of pulmonary endothelial cells from neonatal mice. (Sobczak M, Dargatz J, Chrzanowska-Wodnicka M) J Vis Exp 2010 Dec 14(46) PMID: 21178973 PMCID: PMC3278331 12/24/2010       55 Citations
  • Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes. (Awasthi A, Samarakoon A, Chu H, Kamalakannan R, Quilliam LA, Chrzanowska-Wodnicka M, White GC 2nd, Malarkannan S) J Exp Med 2010 Aug 30;207(9):1923-38 PMID: 20733035 PMCID: PMC2931159 SCOPUS ID: 2-s2.0-77956248916 08/25/2010       33 Citations
  • Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis. (Carbo C, Duerschmied D, Goerge T, Hattori H, Sakai J, Cifuni SM, White GC 2nd, Chrzanowska-Wodnicka M, Luo HR, Wagner DD) J Leukoc Biol 2010 Aug;88(2):313-9 PMID: 20413728 PMCID: PMC2908939 04/24/2010       26 Citations
  • Regulation of angiogenesis by a small GTPase Rap1. (Chrzanowska-Wodnicka M) Vascul Pharmacol 2010 Jul-Aug;53(1-2):1-10 PMID: 20302970 03/23/2010       22 Citations
  • Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling. (Panchatcharam M, Miriyala S, Yang F, Leitges M, Chrzanowska-Wodnicka M, Quilliam LA, Anaya P, Morris AJ, Smyth SS) Int J Biochem Cell Biol 2010 Jun;42(6):965-74 PMID: 20184965 PMCID: PMC2862848 02/27/2010       37 Citations
  • Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation. (Gilio K, Munnix IC, Mangin P, Cosemans JM, Feijge MA, van der Meijden PE, Olieslagers S, Chrzanowska-Wodnicka MB, Lillian R, Schoenwaelder S, Koyasu S, Sage SO, Jackson SP, Heemskerk JW) J Biol Chem 2009 Dec 04;284(49):33750-62 PMID: 19815551 PMCID: PMC2797144 10/10/2009       80 Citations
  • Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity. (Chu H, Awasthi A, White GC 2nd, Chrzanowska-Wodnicka M, Malarkannan S) J Immunol 2008 Sep 01;181(5):3373-83 PMID: 18714009 PMCID: PMC4571460 SCOPUS ID: 2-s2.0-51549097602 08/21/2008       42 Citations
  • A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development. (Chen Y, Yu M, Podd A, Wen R, Chrzanowska-Wodnicka M, White GC, Wang D) Blood 2008 May 01;111(9):4627-36 PMID: 18319399 PMCID: PMC2343596 SCOPUS ID: 2-s2.0-47149093727 03/06/2008       32 Citations
  • Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice. (Chrzanowska-Wodnicka M, Kraus AE, Gale D, White GC 2nd, Vansluys J) Blood 2008 Mar 01;111(5):2647-56 PMID: 17993608 PMCID: PMC2254536 11/13/2007       116 Citations
  • Rap1b is required for normal platelet function and hemostasis in mice. (Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM, Fischer TH, White GC 2nd) J Clin Invest 2005 Mar;115(3):680-7 PMID: 15696195 PMCID: PMC546455 02/08/2005       226 Citations
    • Last update: 09/30/2019
    jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a