Medical College of Wisconsin
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Magdalena Chrzanowska PhD

Magdalena Chrzanowska PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Cancer Center
Member of the Cardiovascular Center


Publications (47)

  • Clinical Spectrum and Outcomes of Neonatal Necrotizing Enterocolitis. (GaŁĄzka P, Chrzanowska M, StyczyŃski J) In Vivo 2021 Jan-Feb;35(1):585-591 PMID: 33402513 PMCID: PMC7880741 01/07/2021    
  • Endothelial Rap1 (Ras-Association Proximate 1) Restricts Inflammatory Signaling to Protect From the Progression of Atherosclerosis. (Singh B, Kosuru R, Lakshmikanthan S, Sorci-Thomas M, Zhang D, Sparapani R, Vasquez-Vivar J, Chrzanowska M) Arterioscler Thromb Vasc Biol 2020 Dec 03:ATVBAHA120315401 PMID: 33267664 12/04/2020    
  • Integration of Rap1 and Calcium Signaling. (Kosuru R, Chrzanowska M) Int J Mol Sci 2020 Feb 27;21(5) PMID: 32120817 PMCID: PMC7084553 SCOPUS ID: 2-s2.0-85081026400 03/04/2020       2 Citations
  • Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling. (Balaji Ragunathrao VA, Anwar M, Akhter MZ, Chavez A, Mao Y, Natarajan V, Lakshmikanthan S, Chrzanowska-Wodnicka M, Dudek AZ, Claesson-Welsh L, Kitajewski JK, Wary KK, Malik AB, Mehta D) Cell Rep 2019 12 10;29(11):3472-3487.e4 PMID: 31825830 PMCID: PMC6927555 SCOPUS ID: 2-s2.0-85075997214 12/12/2019       10 Citations
  • Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier. (Lakshmikanthan S, Sobczak M, Li Calzi S, Shaw L, Grant MB, Chrzanowska-Wodnicka M) J Cell Sci 2018 01 10;131(1) PMID: 29222111 PMCID: PMC5818062 SCOPUS ID: 2-s2.0-85045634293 12/10/2017       13 Citations
  • Rap1b Is an Effector of Axin2 Regulating Crosstalk of Signaling Pathways During Skeletal Development. (Maruyama T, Jiang M, Abbott A, Yu HI, Huang Q, Chrzanowska-Wodnicka M, Chen EI, Hsu W) J Bone Miner Res 2017 Sep;32(9):1816-1828 PMID: 28520221 PMCID: PMC5555789 SCOPUS ID: 2-s2.0-85021369017 05/19/2017       7 Citations
  • Rap1 in endothelial biology. (Chrzanowska-Wodnicka M) Curr Opin Hematol 2017 May;24(3):248-255 PMID: 28178039 PMCID: PMC5920548 SCOPUS ID: 2-s2.0-85011903603 02/09/2017       17 Citations
  • Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization. (Wang H, Han X, Bretz CA, Becker S, Gambhir D, Smith GW, Samulski RJ, Wittchen ES, Quilliam LA, Chrzanowska-Wodnicka M, Hartnett ME) Mol Ther Methods Clin Dev 2016;3:16056 PMID: 27606349 PMCID: PMC4996131 09/09/2016    
  • Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice. (Rana U, Liu Z, Kumar SN, Zhao B, Hu W, Bordas M, Cossette S, Szabo S, Foeckler J, Weiler H, Chrzanowska-Wodnicka M, Holtz ML, Misra RP, Salato V, North PE, Ramchandran R, Miao QR) Dev Biol 2016 Feb 15;410(2):190-201 PMID: 26746789 PMCID: PMC4767500 SCOPUS ID: 2-s2.0-84957847497 01/10/2016       13 Citations
  • Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature. (Chrzanowska-Wodnicka M, White GC 2nd, Quilliam LA, Whitehead KJ) PLoS One 2015;10(12):e0145689 PMID: 26714318 PMCID: PMC4694701 SCOPUS ID: 2-s2.0-84958225316 12/30/2015       18 Citations
  • Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function. (Lakshmikanthan S, Zheng X, Nishijima Y, Sobczak M, Szabo A, Vasquez-Vivar J, Zhang DX, Chrzanowska-Wodnicka M) EMBO Rep 2015 May;16(5):628-37 PMID: 25807985 PMCID: PMC4428051 SCOPUS ID: 2-s2.0-84928885238 03/27/2015       25 Citations
  • The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation. (Kumar S, Xu J, Kumar RS, Lakshmikanthan S, Kapur R, Kofron M, Chrzanowska-Wodnicka M, Filippi MD) J Exp Med 2014 Aug 25;211(9):1741-58 PMID: 25092872 PMCID: PMC4144729 SCOPUS ID: 2-s2.0-84906544640 08/06/2014       39 Citations
  • Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure. (Lakshmikanthan S, Zieba BJ, Ge ZD, Momotani K, Zheng X, Lund H, Artamonov MV, Maas JE, Szabo A, Zhang DX, Auchampach JA, Mattson DL, Somlyo AV, Chrzanowska-Wodnicka M) Arterioscler Thromb Vasc Biol 2014 Jul;34(7):1486-94 PMID: 24790136 PMCID: PMC4224284 SCOPUS ID: 2-s2.0-84903159007 05/03/2014       27 Citations
  • Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization. (Wang H, Jiang Y, Shi D, Quilliam LA, Chrzanowska-Wodnicka M, Wittchen ES, Li DY, Hartnett ME) FASEB J 2014 Jan;28(1):265-74 PMID: 24043260 PMCID: PMC3868836 SCOPUS ID: 2-s2.0-84894574261 09/18/2013       13 Citations
  • Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo. (Wittchen ES, Nishimura E, McCloskey M, Wang H, Quilliam LA, Chrzanowska-Wodnicka M, Hartnett ME) PLoS One 2013;8(9):e73070 PMID: 24039860 PMCID: PMC3769400 SCOPUS ID: 2-s2.0-84883828886 09/17/2013       23 Citations
  • Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction. (Chrzanowska-Wodnicka M) Exp Cell Res 2013 Sep 10;319(15):2350-9 PMID: 23911990 PMCID: PMC3913003 08/06/2013    
  • Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling. (Zhang G, Xiang B, Ye S, Chrzanowska-Wodnicka M, Morris AJ, Gartner TK, Whiteheart SW, White GC 2nd, Smyth SS, Li Z) J Biol Chem 2011 Nov 11;286(45):39466-77 PMID: 21940635 PMCID: PMC3234770 SCOPUS ID: 2-s2.0-80655144733 09/24/2011       49 Citations
  • Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃. (Lakshmikanthan S, Sobczak M, Chun C, Henschel A, Dargatz J, Ramchandran R, Chrzanowska-Wodnicka M) Blood 2011 Aug 18;118(7):2015-26 PMID: 21636859 PMCID: PMC3158727 SCOPUS ID: 2-s2.0-80051865329 06/04/2011       66 Citations
  • [Iatrogenic pleuropneumonia as a complication of nutritional treatment of preterm-delivery newborn]. (Jakubczyk M, Chrzanowska M, Szkulmowski Z, Apanasiewicz M, Chrupek M, Kaźmirczuk R, Reszczyńska M, Prokurat AI, Kusza K) Med Wieku Rozwoj 2010 Oct-Dec;14(4):365-9 PMID: 21462481 04/06/2011       1 Citation
  • The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity. (Zieba BJ, Artamonov MV, Jin L, Momotani K, Ho R, Franke AS, Neppl RL, Stevenson AS, Khromov AS, Chrzanowska-Wodnicka M, Somlyo AV) J Biol Chem 2011 May 13;286(19):16681-92 PMID: 21454546 PMCID: PMC3089510 SCOPUS ID: 2-s2.0-79955764385 04/02/2011       69 Citations
  • [Iatrogenic pleuropneumonia complicating central venous cannulation in a very low birth weight infant]. (Jakubczyk M, Chrzanowska M, Apanasiewicz M, Chrupek M, Kaźmirczuk R, Reszczyńska M, Prokurat AI, Szkulmowski Z, Kusza K) Anestezjol Intens Ter 2010 Jul-Sep;42(3):147-50 PMID: 21413420 03/19/2011       1 Citation
  • Isolation and culture of pulmonary endothelial cells from neonatal mice. (Sobczak M, Dargatz J, Chrzanowska-Wodnicka M) J Vis Exp 2010 Dec 14(46) PMID: 21178973 PMCID: PMC3278331 SCOPUS ID: 2-s2.0-80055108172 12/24/2010       58 Citations
  • Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes. (Awasthi A, Samarakoon A, Chu H, Kamalakannan R, Quilliam LA, Chrzanowska-Wodnicka M, White GC 2nd, Malarkannan S) J Exp Med 2010 Aug 30;207(9):1923-38 PMID: 20733035 PMCID: PMC2931159 SCOPUS ID: 2-s2.0-77956248916 08/25/2010       35 Citations
  • Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis. (Carbo C, Duerschmied D, Goerge T, Hattori H, Sakai J, Cifuni SM, White GC 2nd, Chrzanowska-Wodnicka M, Luo HR, Wagner DD) J Leukoc Biol 2010 Aug;88(2):313-9 PMID: 20413728 PMCID: PMC2908939 SCOPUS ID: 2-s2.0-77956412592 04/24/2010       26 Citations
  • Regulation of angiogenesis by a small GTPase Rap1. (Chrzanowska-Wodnicka M) Vascul Pharmacol 2010 Jul-Aug;53(1-2):1-10 PMID: 20302970 SCOPUS ID: 2-s2.0-77952549816 03/23/2010       22 Citations
  • Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling. (Panchatcharam M, Miriyala S, Yang F, Leitges M, Chrzanowska-Wodnicka M, Quilliam LA, Anaya P, Morris AJ, Smyth SS) Int J Biochem Cell Biol 2010 Jun;42(6):965-74 PMID: 20184965 PMCID: PMC2862848 SCOPUS ID: 2-s2.0-77953812743 02/27/2010       38 Citations
  • Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation. (Gilio K, Munnix IC, Mangin P, Cosemans JM, Feijge MA, van der Meijden PE, Olieslagers S, Chrzanowska-Wodnicka MB, Lillian R, Schoenwaelder S, Koyasu S, Sage SO, Jackson SP, Heemskerk JW) J Biol Chem 2009 Dec 04;284(49):33750-62 PMID: 19815551 PMCID: PMC2797144 SCOPUS ID: 2-s2.0-71749121027 10/10/2009       85 Citations
  • Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation. (Wang Z, Holly SP, Larson MK, Liu J, Yuan W, Chrzanowska-Wodnicka M, White GC 2nd, Parise LV) J Thromb Haemost 2009 Apr;7(4):693-700 PMID: 19192113 PMCID: PMC2904080 SCOPUS ID: 2-s2.0-63049104047 02/05/2009       14 Citations
  • Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity. (Chu H, Awasthi A, White GC 2nd, Chrzanowska-Wodnicka M, Malarkannan S) J Immunol 2008 Sep 01;181(5):3373-83 PMID: 18714009 PMCID: PMC4571460 SCOPUS ID: 2-s2.0-51549097602 08/21/2008       42 Citations
  • A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development. (Chen Y, Yu M, Podd A, Wen R, Chrzanowska-Wodnicka M, White GC, Wang D) Blood 2008 May 01;111(9):4627-36 PMID: 18319399 PMCID: PMC2343596 SCOPUS ID: 2-s2.0-47149093727 03/06/2008       32 Citations
  • Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice. (Chrzanowska-Wodnicka M, Kraus AE, Gale D, White GC 2nd, Vansluys J) Blood 2008 Mar 01;111(5):2647-56 PMID: 17993608 PMCID: PMC2254536 SCOPUS ID: 2-s2.0-41949111990 11/13/2007       117 Citations
  • Focal adhesion assembly. (Burridge K, Chrzanowska-Wodnicka M, Zhong C) Trends Cell Biol 1997 Sep;7(9):342-7 PMID: 17708978 SCOPUS ID: 2-s2.0-0030770929 08/22/2007    
  • Erratum: Rap1b is required for normal platelet function and hemostasis in mice (Journal of Clinical Investigation (2005) 115 (680-687) DOI: 10.1172/JCI200522973) (Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM, Fischer TH, White GC) Journal of Clinical Investigation August 2005;115(8):2296 SCOPUS ID: 2-s2.0-23644461021 08/01/2005    
  • Rap1b is required for normal platelet function and hemostasis in mice. (Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM, Fischer TH, White GC 2nd) J Clin Invest 2005 Mar;115(3):680-7 PMID: 15696195 PMCID: PMC546455 SCOPUS ID: 2-s2.0-14644400415 02/08/2005       229 Citations
  • G2A is an oncogenic G protein-coupled receptor. (Zohn IE, Klinger M, Karp X, Kirk H, Symons M, Chrzanowska-Wodnicka M, Der CJ, Kay RJ) Oncogene 2000 Aug 10;19(34):3866-77 PMID: 10951580 SCOPUS ID: 2-s2.0-0034632681 08/22/2000       56 Citations
  • Novel fluorescent technology platform for high throughput cytotoxicity and proliferation assays. (Wodnicka M, Guarino RD, Hemperly JJ, Timmins MR, Stitt D, Pitner JB) J Biomol Screen 2000 Jun;5(3):141-52 PMID: 10894757 SCOPUS ID: 2-s2.0-0033945450 07/14/2000       86 Citations
  • Microtubule depolymerization induces stress fibers, focal adhesions, and DNA synthesis via the GTP-binding protein Rho. (Liu BP, Chrzanowska-Wodnicka M, Burridge K) Cell Adhes Commun 1998 Jun;5(4):249-55 PMID: 9762466 SCOPUS ID: 2-s2.0-0032454273 10/08/1998       157 Citations
  • Rho-mediated contractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly. (Zhong C, Chrzanowska-Wodnicka M, Brown J, Shaub A, Belkin AM, Burridge K) J Cell Biol 1998 Apr 20;141(2):539-51 PMID: 9548730 PMCID: PMC2148448 SCOPUS ID: 2-s2.0-0032550177 05/23/1998       459 Citations
  • Mas oncogene signaling and transformation require the small GTP-binding protein Rac. (Zohn IE, Symons M, Chrzanowska-Wodnicka M, Westwick JK, Der CJ) Mol Cell Biol 1998 Mar;18(3):1225-35 PMID: 9488437 PMCID: PMC108835 SCOPUS ID: 2-s2.0-0031935592 03/06/1998       65 Citations
  • Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. (Khosravi-Far R, White MA, Westwick JK, Solski PA, Chrzanowska-Wodnicka M, Van Aelst L, Wigler MH, Der CJ) Mol Cell Biol 1996 Jul;16(7):3923-33 PMID: 8668210 PMCID: PMC231389 SCOPUS ID: 2-s2.0-0029890896 07/01/1996       322 Citations
  • Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. (Chrzanowska-Wodnicka M, Burridge K) J Cell Biol 1996 Jun;133(6):1403-15 PMID: 8682874 PMCID: PMC2120895 SCOPUS ID: 2-s2.0-0029995797 06/01/1996       1332 Citations
  • Focal adhesions, contractility, and signaling. (Burridge K, Chrzanowska-Wodnicka M) Annu Rev Cell Dev Biol 1996;12:463-518 PMID: 8970735 SCOPUS ID: 2-s2.0-0029731588 01/01/1996       1597 Citations
  • Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation. (Chrzanowska-Wodnicka M, Burridge K) J Cell Sci 1994 Dec;107 ( Pt 12):3643-54 PMID: 7706413 SCOPUS ID: 2-s2.0-0028557424 12/01/1994       135 Citations
  • Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras. (Khosravi-Far R, Chrzanowska-Wodnicka M, Solski PA, Eva A, Burridge K, Der CJ) Mol Cell Biol 1994 Oct;14(10):6848-57 PMID: 7935402 PMCID: PMC359215 SCOPUS ID: 2-s2.0-0028075246 10/01/1994       122 Citations
  • Polymorphism of fiber cell junctions in mammalian lens (Costello MJ, Al-Ghoul KJ, Oliver TN, Lane CW, Wodnicka M, Wodnicki P) Proceedings - Annual Meeting, Microscopy Society of America 1993:200-201 SCOPUS ID: 2-s2.0-0027704539 12/01/1993    
  • Rho, rac and the actin cytoskeleton. (Chrzanowska-Wodnicka M, Burridge K) Bioessays 1992 Nov;14(11):777-8 PMID: 1365891 SCOPUS ID: 2-s2.0-0026955927 11/01/1992       19 Citations
  • Comparative study on effects of cytochalasins B and D on F-actin content in different cell lines and different culture conditions. (Wodnicka M, Pierzchalska M, Bereiter-Hahn J, Kajstura J) Folia Histochem Cytobiol 1992;30(3):107-11 PMID: 1337523 SCOPUS ID: 2-s2.0-0027024609 01/01/1992       20 Citations
  • Last update: 03/04/2021