Interaction between chemoreceptor and stretch receptor inputs at medullary respiratory neurons. Am J Physiol 1994 Jun;266(6 Pt 2):R1951-61
Date
06/01/1994Pubmed ID
8024052DOI
10.1152/ajpregu.1994.266.6.R1951Scopus ID
2-s2.0-0028276675 (requires institutional sign-in at Scopus site) 23 CitationsAbstract
The interaction between afferent inputs from carotid body chemoreceptors (CCRs) and from slowly adapting pulmonary stretch receptors (PSRs) on the discharge patterns of medullary inspiratory (I) and expiratory (E) neurons was characterized in thiopental sodium-anesthetized, paralyzed, ventilated dogs. A cycle-triggered ventilator was used to produce control and test pulmonary afferent input patterns. The CCRs were stimulated by phase-synchronized bolus injections of CO2-saturated saline into the common carotid arteries. Only those neurons whose discharge time course was altered by both inflation and CCR activation were studied. The dorsal respiratory group (DRG) I inflation-insensitive neurons were also included. Cycle-triggered histograms of unit activity were obtained for the neuronal responses to inflation, CO2 bolus, and their combination, as well as for the spontaneous control condition. Linearity of the interaction was tested by comparing the sum of the net individual responses to the net response of the combined afferent inputs. The results suggest that a linear (additive) interaction between CCR and PSR inputs exists for the DRG I inflation-sensitive neurons, the ventral respiratory group (VRG) I decrementing, and caudal VRG E augmenting neurons, while a nonadditive interaction exists for caudal VRG E decrementing bulbospinal neurons. The implications of these findings are discussed.
Author List
Bajić J, Zuperku EJ, Tonković-Capin M, Hopp FAAuthors
Jurica Bajic MD, PhD Assistant Professor in the Anesthesiology department at Medical College of WisconsinEdward J. Zuperku PhD Professor in the Anesthesiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Afferent PathwaysAnimals
Carotid Body
Chemoreceptor Cells
Dogs
Electrophysiology
Female
Ganglia, Spinal
Male
Medulla Oblongata
Neurons
Pulmonary Stretch Receptors
Respiration
