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Reperfused vs. nonreperfused myocardial infarction: when to use which model. Am J Physiol Heart Circ Physiol 2021 Jul 01;321(1):H208-H213

Date

06/12/2021

Pubmed ID

34114891

Pubmed Central ID

PMC8321810

DOI

10.1152/ajpheart.00234.2021

Scopus ID

2-s2.0-85111280369 (requires institutional sign-in at Scopus site)   27 Citations

Abstract

There is a lack of understanding in the cardiac remodeling field regarding the use of nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This Perspectives summarizes the consensus of the authors regarding how to select the optimum model for your experiments and is a part of ongoing efforts to establish rigor and reproducibility in cardiac physiology research.

Author List

Lindsey ML, de Castro Brás LE, DeLeon-Pennell KY, Frangogiannis NG, Halade GV, O'Meara CC, Spinale FG, Kassiri Z, Kirk JA, Kleinbongard P, Ripplinger CM, Brunt KR

Author

Caitlin C. O'Meara PhD Associate Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Disease Models, Animal
Heart
Myocardial Infarction
Myocardial Ischemia
Myocardial Reperfusion