Medical College of Wisconsin
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Caitlin C. O'Meara PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Physiology

Member of the Cardiovascular Research Center

Publications (38)

  • Cardiac dysfunction and altered gene expression in acid ceramidase-deficient mice. (Kleynerman A, Rybova J, McKillop WM, Dlugi TA, Faber ML, Fuller M, O'Meara CC, Medin JA) Am J Physiol Heart Circ Physiol 2025 Jan 01;328(1):H141-H156 PMID: 39665198 PMCID: PMC12233101 SCOPUS ID: 2-s2.0-85213996641 12/12/2024       3 Citations
  • Physiological role and mechanisms of action for a long noncoding haplotype region. (Xue H, Mishra MK, Liu Y, Liu P, Grzybowski M, Pandey R, Usa K, Vanden Avond MA, Bala N, Alli AA, Cowley AW, Qiu Q, Greene AS, Rao S, O'Meara CC, Geurts AM, Liang M) bioRxiv 2024 May 18 PMID: 39282460 PMCID: PMC11398485 09/17/2024    
  • A broadly applicable method for quantifying cardiomyocyte cell division identifies proliferative events following myocardial infarction. (Swift SK, Purdy AL, Buddell T, Lovett JJ, Chanjeevaram SV, Arkatkar A, O'Meara CC, Patterson M) Cell Rep Methods 2024 Sep 16;4(9):100860 PMID: 39255794 PMCID: PMC11440799 SCOPUS ID: 2-s2.0-85204511356 09/11/2024       5 Citations
  • Novel Insights into Post-Myocardial Infarction Cardiac Remodeling through Algorithmic Detection of Cell-Type Composition Shifts. (Gural B, Kirkland L, Hockett A, Sandroni P, Zhang J, Rosa-Garrido M, Swift SK, Chapski D, Flinn MA, O'Meara CC, Vondriska TM, Patterson M, Jensen BC, Rau CD) bioRxiv 2024 Aug 10 PMID: 39149394 PMCID: PMC11326268 08/16/2024    
  • Runx1 is sufficient but not required for cardiomyocyte cell-cycle activation. (Akins KA, Flinn MA, Swift SK, Chanjeevaram SV, Purdy AL, Buddell T, Kolell ME, Andresen KG, Paddock S, Buday SL, Veldman MB, O'Meara CC, Patterson M) Am J Physiol Heart Circ Physiol 2024 Aug 01;327(2):H377-H389 PMID: 38847758 PMCID: PMC11442100 SCOPUS ID: 2-s2.0-85199812831 06/07/2024       6 Citations
  • Global IL4Rα blockade exacerbates heart failure after an ischemic event in mice and humans. (Alvarez-Argote S, Almeida VA, Knas MC, Buday SL, Patterson M, O'Meara CC) Am J Physiol Heart Circ Physiol 2024 May 01;326(5):H1080-H1093 PMID: 38426866 PMCID: PMC11380969 SCOPUS ID: 2-s2.0-85190400498 03/01/2024       5 Citations
  • IL-13 promotes functional recovery after myocardial infarction via direct signaling to macrophages. (Alvarez-Argote S, Paddock SJ, Flinn MA, Moreno CW, Knas MC, Almeida VA, Buday SL, Bakhshian Nik A, Patterson M, Chen YG, Lin CW, O'Meara CC) JCI Insight 2024 Jan 23;9(2) PMID: 38051583 PMCID: PMC10906228 SCOPUS ID: 2-s2.0-85183312687 12/06/2023       12 Citations
  • Myofibroblast Ccn3 is regulated by Yap and Wwtr1 and contributes to adverse cardiac outcomes. (Flinn MA, Alvarez-Argote S, Knas MC, Almeida VA, Paddock SJ, Zhou X, Buddell T, Jamal A, Taylor R, Liu P, Drnevich J, Patterson M, Link BA, O'Meara CC) Front Cardiovasc Med 2023;10:1142612 PMID: 36998974 PMCID: PMC10043314 SCOPUS ID: 2-s2.0-85150879131 04/01/2023       9 Citations
  • Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds. (Swift SK, Purdy AL, Kolell ME, Andresen KG, Lahue C, Buddell T, Akins KA, Rau CD, O'Meara CC, Patterson M) Development 2023 Apr 01;150(7) PMID: 36912240 PMCID: PMC10113957 SCOPUS ID: 2-s2.0-85152488769 03/14/2023       31 Citations
  • Collagen-Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections. (Puzyrenko A, Jacobs ER, Padilla N, Devine A, Aljadah M, Gantner BN, Pan AY, Lai S, Dai Q, Rubenstein JC, North PE, Simpson PM, Willoughby RE, O'Meara CC, Flinn MA, Lough JW, Ibrahim EH, Zheng Z, Sun Y, Felix J, Hunt BC, Ross G, Rui H, Benjamin IJ) J Am Heart Assoc 2023 Feb 21;12(4):e027990 PMID: 36789856 PMCID: PMC10111490 SCOPUS ID: 2-s2.0-85148479620 02/16/2023       9 Citations
  • Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection. (Li S, Olde Heuvel F, Rehman R, Aousji O, Froehlich A, Li Z, Jark R, Zhang W, Conquest A, Woelfle S, Schoen M, O Meara CC, Reinhardt RL, Voehringer D, Kassubek J, Ludolph A, Huber-Lang M, Knöll B, Morganti-Kossmann MC, Brockmann MM, Boeckers T, Roselli F) Nat Commun 2023 Jan 13;14(1):200 PMID: 36639371 PMCID: PMC9839781 SCOPUS ID: 2-s2.0-85146272971 01/14/2023       58 Citations
  • Interleukin 4/13 signaling in cardiac regeneration and repair. (Bakhshian Nik A, Alvarez-Argote S, O'Meara CC) Am J Physiol Heart Circ Physiol 2022 Nov 01;323(5):H833-H844 PMID: 36149768 PMCID: PMC9602781 SCOPUS ID: 2-s2.0-85140273361 09/24/2022       19 Citations
  • Editorial: Role of Molecular Modulators in Combatting Cardiac Injury and Disease: Prevention, Repair and Regeneration. (de Castro Brás LE, Schibalski RS, Ilatovskaya DV, O'Meara CC, DeLeon-Pennell KY) Front Cardiovasc Med 2022;9:861442 PMID: 35509270 PMCID: PMC9058098 SCOPUS ID: 2-s2.0-85138502735 05/06/2022    
  • Measuring cardiomyocyte cell-cycle activity and proliferation in the age of heart regeneration. (Auchampach J, Han L, Huang GN, Kühn B, Lough JW, O'Meara CC, Payumo AY, Rosenthal NA, Sucov HM, Yutzey KE, Patterson M) Am J Physiol Heart Circ Physiol 2022 Apr 01;322(4):H579-H596 PMID: 35179974 PMCID: PMC8934681 SCOPUS ID: 2-s2.0-85127729067 02/19/2022       37 Citations
  • The Evolving Roles of Cardiac Macrophages in Homeostasis, Regeneration, and Repair. (Alvarez-Argote S, O'Meara CC) Int J Mol Sci 2021 Jul 25;22(15) PMID: 34360689 PMCID: PMC8347787 SCOPUS ID: 2-s2.0-85111068209 08/08/2021       42 Citations
  • IL4Rα signaling promotes neonatal cardiac regeneration and cardiomyocyte cell cycle activity. (Paddock SJ, Swift SK, Alencar-Almeida V, Kenarsary A, Alvarez-Argote S, Flinn MA, Patterson M, O'Meara CC) J Mol Cell Cardiol 2021 Dec;161:62-74 PMID: 34343540 PMCID: PMC8629844 SCOPUS ID: 2-s2.0-85112431618 08/04/2021       19 Citations
  • Reperfused vs. nonreperfused myocardial infarction: when to use which model. (Lindsey ML, de Castro Brás LE, DeLeon-Pennell KY, Frangogiannis NG, Halade GV, O'Meara CC, Spinale FG, Kassiri Z, Kirk JA, Kleinbongard P, Ripplinger CM, Brunt KR) Am J Physiol Heart Circ Physiol 2021 Jul 01;321(1):H208-H213 PMID: 34114891 PMCID: PMC8321810 SCOPUS ID: 2-s2.0-85111280369 06/12/2021       35 Citations
  • Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes. (Flinn MA, Otten C, Brandt ZJ, Bostrom JR, Kenarsary A, Wan TC, Auchampach JA, Abdelilah-Seyfried S, O'Meara CC, Link BA) Development 2020 Aug 25;147(16) PMID: 32843528 PMCID: PMC7473637 SCOPUS ID: 2-s2.0-85089923843 08/28/2020       9 Citations
  • Steps toward therapeutically targeting the activin type II receptor for treating heart failure. (Paddock SJ, O'Meara CC) Am J Physiol Heart Circ Physiol 2020 Feb 01;318(2):H326-H328 PMID: 31922889 PMCID: PMC7052619 SCOPUS ID: 2-s2.0-85078814455 01/11/2020       3 Citations
  • Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration. (Flinn MA, Link BA, O'Meara CC) Semin Cell Dev Biol 2020 Apr;100:11-19 PMID: 31606277 PMCID: PMC7263368 SCOPUS ID: 2-s2.0-85073003673 10/14/2019       43 Citations
  • Neuronatin is a modifier of estrogen receptor-positive breast cancer incidence and outcome. (Plasterer C, Tsaih SW, Peck AR, Chervoneva I, O'Meara C, Sun Y, Lemke A, Murphy D, Smith J, Ran S, Kovatich AJ, Hooke JA, Shriver CD, Hu H, Mitchell EP, Bergom C, Joshi A, Auer P, Prokop J, Rui H, Flister MJ) Breast Cancer Res Treat 2019 Aug;177(1):77-91 PMID: 31165373 PMCID: PMC10317546 SCOPUS ID: 2-s2.0-85066986189 06/06/2019       5 Citations
  • IL-13 promotes in vivo neonatal cardiomyocyte cell cycle activity and heart regeneration. (Wodsedalek DJ, Paddock SJ, Wan TC, Auchampach JA, Kenarsary A, Tsaih SW, Flister MJ, O'Meara CC) Am J Physiol Heart Circ Physiol 2019 Jan 01;316(1):H24-H34 PMID: 30339498 SCOPUS ID: 2-s2.0-85060194313 10/20/2018       43 Citations
  • Yap is required for scar formation but not myocyte proliferation during heart regeneration in zebrafish. (Flinn MA, Jeffery BE, O'Meara CC, Link BA) Cardiovasc Res 2019 Mar 01;115(3):570-577 PMID: 30295714 SCOPUS ID: 2-s2.0-85061983162 10/09/2018       33 Citations
  • Soluble interleukin-13rα1: a circulating regulator of glucose. (Rachmin I, O'Meara CC, Ricci-Blair EM, Feng Y, Christensen EM, Duffy JF, Zitting KM, Czeisler CA, Pancoast JR, Cannon CP, O'Donoghue ML, Morrow DA, Lee RT) Am J Physiol Endocrinol Metab 2017 Dec 01;313(6):E663-E671 PMID: 28874358 PMCID: PMC5814599 SCOPUS ID: 2-s2.0-85037052672 09/07/2017       4 Citations
  • Peering Into the Cardiomyocyte Nuclear Epigenetic State. (O'Meara CC, Lee RT) Circ Res 2015 Aug 14;117(5):392-4 PMID: 26271534 PMCID: PMC4538702 SCOPUS ID: 2-s2.0-84939552309 08/15/2015       4 Citations
  • Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. (Mahmoud AI, O'Meara CC, Gemberling M, Zhao L, Bryant DM, Zheng R, Gannon JB, Cai L, Choi WY, Egnaczyk GF, Burns CE, Burns CG, MacRae CA, Poss KD, Lee RT) Dev Cell 2015 Aug 24;34(4):387-99 PMID: 26256209 PMCID: PMC4550513 SCOPUS ID: 2-s2.0-84939777584 08/11/2015       219 Citations
  • Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis. (Jiang J, Burgon PG, Wakimoto H, Onoue K, Gorham JM, O'Meara CC, Fomovsky G, McConnell BK, Lee RT, Seidman JG, Seidman CE) Proc Natl Acad Sci U S A 2015 Jul 21;112(29):9046-51 PMID: 26153423 PMCID: PMC4517252 SCOPUS ID: 2-s2.0-84937873586 07/15/2015       44 Citations
  • Response to "Comment to the article 'A systematic analysis of neonatal mouse heart regeneration after apical resection'". (Bryant DM, O'Meara CC, Ho NN, Gannon J, Cai L, Lee RT) J Mol Cell Cardiol 2015 May;82:184-5 PMID: 25771145 SCOPUS ID: 2-s2.0-84925402989 03/17/2015       1 Citation
  • SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis. (Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ) Circ Cardiovasc Genet 2015 Apr;8(2):294-304 PMID: 25628389 SCOPUS ID: 2-s2.0-84942919523 01/30/2015       28 Citations
  • A systematic analysis of neonatal mouse heart regeneration after apical resection. (Bryant DM, O'Meara CC, Ho NN, Gannon J, Cai L, Lee RT) J Mol Cell Cardiol 2015 Feb;79:315-8 PMID: 25533939 PMCID: PMC4302033 SCOPUS ID: 2-s2.0-84920973650 12/24/2014       91 Citations
  • Transcriptional reversion of cardiac myocyte fate during mammalian cardiac regeneration. (O'Meara CC, Wamstad JA, Gladstone RA, Fomovsky GM, Butty VL, Shrikumar A, Gannon JB, Boyer LA, Lee RT) Circ Res 2015 Feb 27;116(5):804-15 PMID: 25477501 PMCID: PMC4344930 SCOPUS ID: 2-s2.0-84924367823 12/06/2014       135 Citations
  • Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity. (Yeo NC, O'Meara CC, Bonomo JA, Veth KN, Tomar R, Flister MJ, Drummond IA, Bowden DW, Freedman BI, Lazar J, Link BA, Jacob HJ) Genome Res 2015 Jan;25(1):57-65 PMID: 25273069 PMCID: PMC4317173 SCOPUS ID: 2-s2.0-84920650331 10/03/2014       68 Citations
  • Identifying multiple causative genes at a single GWAS locus. (Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C) Genome Res 2013 Dec;23(12):1996-2002 PMID: 24006081 PMCID: PMC3847770 SCOPUS ID: 2-s2.0-84888132259 09/06/2013       93 Citations
  • SORCS1 contributes to the development of renal disease in rats and humans. (Lazar J, O'Meara CC, Sarkis AB, Prisco SZ, Xu H, Fox CS, Chen MH, Broeckel U, Arnett DK, Moreno C, Provoost AP, Jacob HJ) Physiol Genomics 2013 Aug 15;45(16):720-8 PMID: 23780848 PMCID: PMC3742914 SCOPUS ID: 2-s2.0-84882674017 06/20/2013       13 Citations
  • Identification of hypertension susceptibility loci on rat chromosome 12. (Flister MJ, Prisco SZ, Sarkis AB, O'Meara CC, Hoffman M, Wendt-Andrae J, Moreno C, Lazar J, Jacob HJ) Hypertension 2012 Oct;60(4):942-8 PMID: 22868394 PMCID: PMC3873777 SCOPUS ID: 2-s2.0-84866552371 08/08/2012       23 Citations
  • Role of genetic modifiers in an orthologous rat model of ARPKD. (O'Meara CC, Hoffman M, Sweeney WE Jr, Tsaih SW, Xiao B, Jacob HJ, Avner ED, Moreno C) Physiol Genomics 2012 Aug 01;44(15):741-53 PMID: 22669842 PMCID: PMC3774585 SCOPUS ID: 2-s2.0-84865616207 06/07/2012       23 Citations
  • A 4.1-Mb congenic region of Rf-4 contributes to glomerular permeability. (O'Meara CC, Lutz MM, Sarkis AB, Xu H, Kothinti RK, Hoffman M, Moreno C, Tabatabai NM, Lazar J, Roman RJ, Jacob HJ) J Am Soc Nephrol 2012 May;23(5):825-33 PMID: 22343117 PMCID: PMC3338295 SCOPUS ID: 2-s2.0-84860630544 02/22/2012       6 Citations
  • Refined mapping of the renal failure RF-3 quantitative trait locus. (O'Meara CC, Lazar J, Hoffman M, Moreno C, Jacob HJ) J Am Soc Nephrol 2011 Mar;22(3):518-25 PMID: 21127141 PMCID: PMC3060445 SCOPUS ID: 2-s2.0-79952347866 12/04/2010       7 Citations
    • Last update: 09/18/2025