Interaction between the pulmonary stretch receptor and pontine control of expiratory duration. Respir Physiol Neurobiol 2021 Nov;293:103715
Date
06/15/2021Pubmed ID
34126261Pubmed Central ID
PMC8418273DOI
10.1016/j.resp.2021.103715Scopus ID
2-s2.0-85108097773 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Medial parabrachial nucleus (mPBN) neuronal activity plays a key role in controlling expiratory (E)-duration (TE). Pulmonary stretch receptor (PSR) activity during the E-phase prolongs TE. The aims of this study were to characterize the interaction between the PSR and mPBN control of TE and underlying mechanisms. Decerebrated mechanically ventilated dogs were studied. The mPBN subregion was activated by electrical stimulation via bipolar microelectrode. PSR afferents were activated by low-level currents applied to the transected central vagus nerve. Both stimulus-frequency patterns during the E-phase were synchronized to the phrenic neurogram; TE was measured. A functional mathematical model for the control of TE and extracellular recordings from neurons in the preBötzinger/Bötzinger complex (preBC/BC) were used to understand mechanisms. Findings show that the mPBN gain-modulates, via attenuation, the PSR-mediated reflex. The model suggested functional sites for attenuation and neuronal data suggested correlates. The PSR- and PB-inputs appear to interact on E-decrementing neurons, which synaptically inhibit pre-I neurons, delaying the onset of the next I-phase.
Author List
Zuperku EJ, Hopp FA, Stuth EAE, Stucke AGAuthors
Astrid G. Stucke MD Professor in the Anesthesiology department at Medical College of WisconsinEckehard A. Stuth MD Professor in the Anesthesiology department at Medical College of Wisconsin
Edward J. Zuperku PhD Professor in the Anesthesiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsDogs
Electric Stimulation
Exhalation
Parabrachial Nucleus
Pulmonary Stretch Receptors
Reflex
Time Factors
