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Immunocytes and abnormal gastrointestinal motor activity during ileitis in dogs. Am J Physiol 1995 Dec;269(6 Pt 1):G913-24

Date

12/01/1995

Pubmed ID

8572223

DOI

10.1152/ajpgi.1995.269.6.G913

Scopus ID

2-s2.0-0029616583 (requires institutional sign-in at Scopus site)   39 Citations

Abstract

Infiltration of specific immunocytes and stimulation of abnormal gastrointestinal motor activity during ileal inflammation induced by mucosal exposure to ethanol and acetic acid were investigated in 17 dogs. Ileal inflammation significantly increased the frequency of giant migrating contractions (GMCs) and decreased the frequency of migrating motor complexes (MMCs). The frequency of retrograde giant contractions (RGCs) increased only on the day of ethanol and acetic acid treatment. Diarrhea, urgency of defecation, and apparent abdominal discomfort were related to the increased frequency of GMCs. Ileal inflammation also prolonged the duration of postprandial MMC disruption. Histological and immunohistochemical findings indicated transmural inflammation with marked increase in polymorphonuclear cells in the lamina propria and muscularis externa layers. Myeloperoxidase activity increased severalfold in both layers. Cells containing interleukin-2 receptor (IL-2R) increased in the lamina propria. Other immunocytes, such as B and T lymphocytes, dendritic cells, and human leukocyte antigen DR-1 (HLADR)-positive cells, did not exhibit a significant increase in the inflamed ileum compared with the normal proximal jejunum. We conclude that stimulation of GMCs may be the major motility marker of intestinal inflammation.

Author List

Jouët P, Sarna SK, Singaram C, Ryan RP, Hillard CJ, Telford GL, Fink J, Henderson JD

Author

Cecilia J. Hillard PhD Associate Dean, Center Director, Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Dogs
Female
Gastrointestinal Motility
Ileitis
Immune System
Immunohistochemistry
Intestinal Mucosa
Intestine, Small
Intestines
Male
Muscle Contraction
Myoelectric Complex, Migrating
Peroxidase