Vascular endothelial adiponectin signaling across the life span. Am J Physiol Heart Circ Physiol 2022 Jan 01;322(1):H57-H65
Date
11/20/2021Pubmed ID
34797171Pubmed Central ID
PMC8698498DOI
10.1152/ajpheart.00533.2021Scopus ID
2-s2.0-85122249089 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Cardiovascular disease risk increases with age regardless of sex. Some of this risk is attributable to alterations in natural hormones throughout the life span. The quintessential example of this being the dramatic increase in cardiovascular disease following the transition to menopause. Plasma levels of adiponectin, a "cardioprotective" adipokine released primarily by adipose tissue and regulated by hormones, also fluctuate throughout one's life. Plasma adiponectin levels increase with age in both men and women, with higher levels in both pre- and postmenopausal women compared with men. Younger cohorts seem to confer cardioprotective benefits from increased adiponectin levels yet elevated levels in the elderly and those with existing heart disease are associated with poor cardiovascular outcomes. Here, we review the most recent data regarding adiponectin signaling in the vasculature, highlight the differences observed between the sexes, and shed light on the apparent paradox regarding increased cardiovascular disease risk despite rising plasma adiponectin levels over time.
Author List
Cohen KE, Katunaric B, SenthilKumar G, McIntosh JJ, Freed JKAuthors
Katie E. Cohen MD Instructor in the Medicine department at Medical College of WisconsinJulie K. Freed MD, PhD Vice Chair, Associate Professor in the Anesthesiology department at Medical College of Wisconsin
Jennifer Jury Mcintosh DO Associate Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdiponectinAging
Animals
Endothelium, Vascular
Humans
Signal Transduction
