Diffusion propagator metrics are biased when simultaneous multi-slice acceleration is used. Magn Reson Imaging 2022 Feb;86:46-54
Date
11/22/2021Pubmed ID
34801673DOI
10.1016/j.mri.2021.11.003Scopus ID
2-s2.0-85119508656 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Advanced diffusion MRI models are being explored to study the complex microstructure of the brain with higher accuracy. However, these techniques require long acquisition times. Simultaneous Multi-Slice (SMS) accelerates data acquisition by exciting multiple image slices simultaneously and separating the overlapping slices using a mathematical model, which makes use of the distinct information coming from an array of receive coils. However, SMS acceleration introduces increased noise in reconstructed images and crosstalk between simultaneously excited slices. These compounded effects from SMS acceleration could affect quantitative MRI techniques such as diffusion imaging. In this study, the effects of SMS acceleration on the accuracy of propagator metrics obtained from a model-free advanced diffusion technique called Mean Apparent Propagator MRI (MAP-MRI) was investigated. Ten healthy volunteers were scanned with SMS accelerated multi-shell diffusion MRI acquisitions. Group analyses were performed to study brain regions affected by SMS acceleration. In addition, diffusion metrics from atlas-based fiber tracts of interest were analyzed to investigate how propagator metrics in major fiber tracts were biased by 2- and 3-band SMS acceleration. Both zero-displacement metrics and non-Gaussianity metrics were significantly altered when SMS acceleration was used. MAP-MRI metrics calculated from SMS-3 showed significant differences with respect to SMS-2. Furthermore, with the shorter TR afforded by SMS acceleration, the characteristics of this bias have changed. This has implications for studies using diffusion MRI with SMS acceleration to investigate the effects of a disease or injury on the brain tissues.
Author List
Muftuler LT, Nencka AS, Koch KMAuthors
Kevin M. Koch PhD Center Director, Professor in the Radiology department at Medical College of WisconsinLutfi Tugan Muftuler PhD Professor in the Neurosurgery department at Medical College of Wisconsin
Andrew S. Nencka PhD Director, Associate Professor in the Radiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AccelerationBenchmarking
Brain
Diffusion Magnetic Resonance Imaging
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
