Faculty Collaboration Database

Selective incorporation of 111In-labeled PHOTOFRIN by glioma tissue in vivo. J Neurooncol 1994;22(1):7-13

Date

01/01/1994

Pubmed ID

7714553

DOI

10.1007/BF01058350

Scopus ID

2-s2.0-0028670925 (requires institutional sign-in at Scopus site)   21 Citations

Abstract

The use of PHOTOFRIN for photodynamic therapy of human gliomas has been studied by i.v. administration and laser photosensitization. Defining the uptake of PHOTOFRIN in the patient's tumor in comparison with the surrounding normal brain tissue is highly desirable for patient selection and study of in vivo kinetics. We utilized a non-invasive approach to the detection of PHOTOFRIN uptake in brain tumors with 111In-oxine radiolabeled PHOTOFRIN and external imaging and quantitation using a gamma camera. Biodistribution of 111In-labeled PHOTOFRIN in 13 organs was determined in four dogs and 15 mice with gliomas. 99mTc-DTPA was used as a control for nonspecific uptake. The greatest concentration of 111In-PHOTOFRIN in the brain tumor occurred at 24 hours post i.v. administration. The brain tumor PHOTOFRIN uptake was seven times greater than that of normal brain. The decreased blood background at 72 hours made this the optimum time for imaging. Specific tumor tissue uptake of 111In-PHOTOFRIN occurred, well beyond that resulting from blood-brain-barrier (BBB) breakdown.

Author List

Whelan HT, Kras LH, Ozker K, Bajic D, Schmidt MH, Liu Y, Trembath LA, Uzum F, Meyer GA, Segura AD

Author

Annette D. Segura MD Adjunct Assistant Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Brain Neoplasms
Dogs
Glioma
Hematoporphyrin Derivative
Indium Radioisotopes
Magnetic Resonance Imaging
Mice
Mice, Nude
Radionuclide Imaging
Tissue Distribution
Tumor Cells, Cultured