Faculty Collaboration Database

Incidence of cancer among patients with systemic sclerosis. Cancer 1995 Sep 01;76(5):910-4

Date

09/01/1995

Pubmed ID

8625197

DOI

10.1002/1097-0142(19950901)76:5<910::aid-cncr2820760528>3.0.co;2-t

Scopus ID

2-s2.0-0029121828 (requires institutional sign-in at Scopus site)   183 Citations

Abstract

BACKGROUND: To determine cancer risk among patients with systemic sclerosis and localized scleroderma, a population-based retrospective cohort study was performed. Patients in Sweden with a discharge diagnosis of systemic sclerosis or localized scleroderma were obtained from the computerized database of hospital discharge diagnoses for the years 1965-1983. Nine hundred seventeen patients with systemic sclerosis and 102 with localized scleroderma were identified.

METHODS: Using record linkage analysis with data from the Swedish National Cancer Registry, standardized incidence ratios (SIR)s (the ratio of observed to expected incidence) were calculated for specific cancer sites.

RESULTS: The SIR for developing cancer in the cohort with systemic sclerosis was 1.5 (95% CI, 1.2-1.9). For specific cancer sites, risks were elevated for lung cancer (SIR, 4.9; 95% CI, 2.8-8.1), nonmelanoma skin cancers (SIR, 4.2; 95% CI, 1.4-9.8), and primary liver cancer (SIR, 3.3; 95% CI, 1.1-7.6). There was a suggestive increase in hematopoietic cancers (SIR, 2.3; 95% CI, 0.9-4.8). In contrast, cancer risks in the similarly ascertained cohort with localized scleroderma were no different from those of the general population.

CONCLUSIONS: This study confirms earlier reports of an association between systemic sclerosis and an increased risk of cancer. Specific tumor sites correspond to the sites commonly affected by fibrosis such as the lung and skin.

Author List

Rosenthal AK, McLaughlin JK, Gridley G, Nyrén O

Author

Ann K. Rosenthal MD Associate Dean, Chief, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Cohort Studies
Female
Humans
Male
Middle Aged
Neoplasms
Retrospective Studies
Risk Factors
Scleroderma, Localized
Scleroderma, Systemic