"Early death" and the contraindication of vaccine during treatment of rabies. Vaccine 2009 Nov 27;27(51):7173-7
Date
11/21/2009Pubmed ID
19925949DOI
10.1016/j.vaccine.2009.09.032Scopus ID
2-s2.0-71549117566 19 CitationsAbstract
Administration of rabies vaccine or rabies immune globulin (RIG) during symptomatic rabies is ineffective, and there are concerns about the phenomenon of "early death" reported in animals that develop rabies after receipt of rabies vaccine or immune globulin. Survival analyses of the original animal data confirm these findings in two species, whereas analyses of human case reports and the Milwaukee Protocol registry suggest lower risk of "early death" in humans. There may be a deleterious interaction of rabies vaccine and RIG with bat rabies in humans. Animal studies of bat rabies virus with bat-origin vaccines and RIG are urgently needed.
Author List
Willoughby RE JrAuthor
Rodney E. Willoughby MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsContraindications
Humans
Immunoglobulins
Kaplan-Meier Estimate
Post-Exposure Prophylaxis
Rabies
Rabies Vaccines
