Faculty Collaboration Database

The changing susceptibilities of methicillin-resistant Staphylococcus aureus at a midwestern hospital: the emergence of "community-associated" MRSA. Am J Infect Control 2009 Aug;37(6):454-7

Date

01/03/2009

Pubmed ID

19118922

DOI

10.1016/j.ajic.2008.09.015

Scopus ID

2-s2.0-67651067922 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

BACKGROUND: The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has been well described; however, few studies have reviewed long-term hospital-wide data.

METHODS: This retrospective study of adult patients used the first culture per patient per visit positive for MRSA for 1996 to 2005. Isolates were categorized as community-associated or health care-associated phenotype based on antibiotic susceptibilities. chi(2) tests for trend and linear regression analyses were performed.

RESULTS: The annual prevalence of CA-MRSA increased significantly over the 10-year study period (from 43 of 507 [8.9%] MRSA cultures in 1996 to 672 of 1697 [39.6%] MRSA cultures in 2005; P < .01). The proportion of MRSA cultures obtained within 48 hours of hospital admission increased from 50.5% to 79.5% (P < .01). The median age of patients with MRSA decreased, from 60 to 49 years (P < .01). Among the CA-MRSA cases, the proportion of non-Caucasian patients increased from 30.2% to 60.4% (P < .01) and the proportion of patients categorized as low socioeconomic status increased from 25.6% to 35.6% (P < .01). Significant consistent trends were not observed for patient sex or body sites of the cultures.

CONCLUSION: An increasing number of MRSA with a community-associated phenotype occurred during the 10-year study period. Patterns of decreasing age, increasing non-Caucasian races, and decreasing socioeconomic status were observed among patients with MRSA.

Author List

McMullen KM, Warren DK, Woeltje KF

Author

Keith F. Woeltje MD, PhD Associate Dean, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Community-Acquired Infections
Drug Resistance, Bacterial
Female
Hospitals
Humans
Male
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Middle Aged
Midwestern United States
Prevalence
Retrospective Studies
Socioeconomic Factors
Staphylococcal Infections
Young Adult