Serious Pseudomonas aeruginosa infections in patients infected with human immunodeficiency virus: a case-control study. Clin Infect Dis 1994 Sep;19(3):417-22
Date
09/01/1994Pubmed ID
7811859DOI
10.1093/clinids/19.3.417Scopus ID
2-s2.0-0028145501 (requires institutional sign-in at Scopus site) 71 CitationsAbstract
We conducted a case-control study to determine the incidence and clinical features of and risk factors for Pseudomonas aeruginosa infections in patients infected with human immunodeficiency virus (HIV). Twenty-five patients who had 37 episodes of P. aeruginosa infection from 1990 through 1992 were identified. Most of the patients (92%) were homosexual men with low CD4+ lymphocyte counts and a history of AIDS. The annual incidence rates of P. aeruginosa infection were 3.5% (1990), 6.3% (1991), and 8.7% (1992). Most infections were community-acquired (68%) and involved the respiratory tract (73%). Patients were more likely than HIV-infected controls to have AIDS and had more AIDS-defining opportunistic illnesses. The overall mortality was 36%. Recurrent episodes were common (39%). We conclude that P. aeruginosa infections may be an increasing problem in patients with extremely advanced HIV infection. Clinicians should consider including antibiotics with activity against P. aeruginosa in the empirical treatment for suspected bacterial infection in patients with advanced HIV infection.
Author List
Fichtenbaum CJ, Woeltje KF, Powderly WGAuthor
Keith F. Woeltje MD, PhD Associate Dean, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AIDS-Related Opportunistic InfectionsAcquired Immunodeficiency Syndrome
Adult
Case-Control Studies
Female
Humans
Incidence
Male
Pseudomonas Infections
Recurrence
Retrospective Studies
