Pediatric Autoimmune Liver Diseases: Autoimmune Hepatitis and Primary Sclerosing Cholangitis. Pediatr Clin North Am 2021 Dec;68(6):1293-1307
Date
11/06/2021Pubmed ID
34736590DOI
10.1016/j.pcl.2021.07.006Scopus ID
2-s2.0-85118509157 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
In chronic hepatitis, a broad differential diagnosis should be considered to accurately identify the cause(s) of liver injury. Autoimmune liver diseases (autoimmune hepatitis, primary sclerosing cholangitis, overlap syndrome) can occur in the setting of limited symptoms; therefore, a high index of suspicion and appropriate diagnostic workup should be performed. Most children with autoimmune hepatitis achieve sustained remission with medical therapy; however, there are no equivalent therapies for primary sclerosing cholangitis that impact the progression of disease. Research should include biomarker studies to predict histologic remission in autoimmune hepatitis and mechanistic studies to define future treatment targets for primary sclerosing cholangitis.
Author List
Kemme S, Mack CLAuthor
Cara Lynn Mack MD Chief, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAsymptomatic Diseases
Autoimmune Diseases
Azathioprine
Biomarkers
Child
Cholangitis, Sclerosing
Female
Glucocorticoids
Hepatitis, Autoimmune
Humans
Liver
Liver Diseases
Liver Transplantation
Male
Syndrome
Transaminases
Young Adult
