Faculty Collaboration Database

SR-B1's Next Top Model: Structural Perspectives on the Functions of the HDL Receptor. Curr Atheroscler Rep 2022 Apr;24(4):277-288

Date

02/03/2022

Pubmed ID

35107765

Pubmed Central ID

PMC8809234

DOI

10.1007/s11883-022-01001-1

Scopus ID

2-s2.0-85124168322 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

PURPOSE OF REVIEW: The binding of high-density lipoprotein (HDL) to its primary receptor, scavenger receptor class B type 1 (SR-B1), is critical for lowering plasma cholesterol levels and reducing cardiovascular disease risk. This review provides novel insights into how the structural elements of SR-B1 drive efficient function with an emphasis on bidirectional cholesterol transport.

RECENT FINDINGS: We have generated a new homology model of full-length human SR-B1 based on the recent resolution of the partial structures of other class B scavenger receptors. Interrogating this model against previously published observations allows us to generate structurally informed hypotheses about SR-B1's ability to mediate HDL-cholesterol (HDL-C) transport. Furthermore, we provide a structural perspective as to why human variants of SR-B1 may result in impaired HDL-C clearance. A comprehensive understanding of SR-B1's structure-function relationships is critical to the development of therapeutic agents targeting SR-B1 and modulating cardiovascular disease risk.

Author List

Powers HR, Sahoo D

Author

Daisy Sahoo PhD Dean, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Cardiovascular Diseases
Cholesterol, HDL
Humans
Lipoproteins, HDL
Receptors, Lipoprotein
Scavenger Receptors, Class B