Faculty Collaboration Database

Determinants of bone and blood lead levels among minorities living in the Boston area. Environ Health Perspect 2004 Aug;112(11):1147-51

Date

08/04/2004

Pubmed ID

15289158

Pubmed Central ID

PMC1247473

DOI

10.1289/ehp.6705

Scopus ID

2-s2.0-4344571661 (requires institutional sign-in at Scopus site)   33 Citations

Abstract

We measured blood and bone lead levels among minority individuals who live in some of Boston's neighborhoods with high minority representation. Compared with samples of predominantly white subjects we had studied before, the 84 volunteers in this study (33:67 male:female ratio; 31-72 years of age) had similar educational, occupational, and smoking profiles and mean blood, tibia, and patella lead levels (3 microg/dL, 11.9 microg/g, and 14.2 microg/g, respectively) that were also similar. The slopes of the univariate regressions of blood, tibia, and patella lead versus age were 0.10 microg/dL/year (p < 0.001), 0.45 microg/g/year (p < 0.001), and 0.73 microg/g/year (p < 0.001), respectively. Analyses of smoothing curves and regression lines for tibia and patella lead suggested an inflection point at 55 years of age, with slopes for subjects greater than or equal to 55 years of age that were not only steeper than those of younger subjects but also substantially steeper than those observed for individuals > 55 years of age in studies of predominantly white participants. This apparent racial disparity at older ages may be related to differences in historic occupational and/or environmental exposures, or possibly the lower rates of bone turnover that are known to occur in postmenopausal black women. The higher levels of lead accumulation seen in this age group are of concern because such levels have been shown in other studies to predict elevated risks of chronic disease such as hypertension and cognitive dysfunction. Additional research on bone lead levels in minorities and their socioeconomic and racial determinants is needed.

Author List

Lin C, Kim R, Tsaih SW, Sparrow D, Hu H

Author

Shirng-Wern Tsaih Research Scientist II in the Obstetrics and Gynecology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Age Factors
Aged
Bone and Bones
Boston
Chronic Disease
Cross-Sectional Studies
Female
Humans
Lead
Lead Poisoning
Male
Middle Aged
Risk Assessment
Urban Population