Apolipoprotein E genotype predicts 24-month bayley scales infant development score. Pediatr Res 2003 Dec;54(6):819-25
Date
08/22/2003Pubmed ID
12930912DOI
10.1203/01.PDR.0000090927.53818.DEScopus ID
2-s2.0-0345276807 (requires institutional sign-in at Scopus site) 128 CitationsAbstract
Apolipoprotein E (APOE) regulates cholesterol and fatty acid metabolism, and may mediate synaptogenesis during neurodevelopment. To our knowledge, the effects of APOE4 isoforms on infant development have not been studied. This study was nested within a cohort of mother-infant pairs living in and around Mexico City. A multiple linear regression model was constructed using the 24-mo Mental Development Index (MDI) of the Bayley Scale as the primary outcome and infant APOE genotype as the primary risk factor of interest. Regression models stratified on APOE genotype were constructed to explore effect modification. Of 311 subjects, 53 (17%) carried at least one copy of the APOE4 allele. Mean (SD) MDI scores among carriers with at least one copy of APOE4 were 94.1 (14.3) and among E3/E2 carriers were 91.2 (14.0). After adjustment for covariates, APOE4 carrier status was associated with a 4.4 point (95% confidence interval: 0.1-8.7; p = 0.04) higher 24-mo MDI. In the stratified regression models, the negative effects for umbilical cord blood lead level on 24-mo MDI score was approximately 4-fold greater among APOE3/APOE2 carriers than among APOE4 carriers. These results suggest that subjects with the E4 isoform of APOE may have advantages over those with the E2 or E3 isoforms with respect to early life neuronal/brain development.
Author List
Wright RO, Hu H, Silverman EK, Tsaih SW, Schwartz J, Bellinger D, Palazuelos E, Weiss ST, Hernandez-Avila MAuthor
Shirng-Wern Tsaih Research Scientist II in the Obstetrics and Gynecology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Apolipoprotein E2Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E
Cohort Studies
Female
Fetal Blood
Genotype
Humans
Infant, Newborn
Lead
Lead Poisoning
Male
Multivariate Analysis
Neonatal Screening
Predictive Value of Tests
Pregnancy
Prenatal Exposure Delayed Effects
Risk Factors
