Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives. Acta Biomater 2011 Aug;7(8):3150-7
Date
05/17/2011Pubmed ID
21569875Pubmed Central ID
PMC4059060DOI
10.1016/j.actbio.2011.04.022Scopus ID
2-s2.0-79959844652 (requires institutional sign-in at Scopus site) 73 CitationsAbstract
Cyanoacrylate glues are easily applied to wounds with good cosmetic results. However, they tend to be brittle and can induce local tissue toxicity. A series of cyanoacrylate monomers with a flexible ether linkage and varying side-chain lengths was synthesized and characterized for potential use as tissue adhesives. The effect of side-chain length on synthesis yield, physical and mechanical properties, formaldehyde generation, cytotoxicity in vitro and biocompatibility in vivo were examined. The incorporation of etheric oxygen allowed the production of flexible monomers with good adhesive strength. Monomers with longer side-chains were found to have less toxicity both in vitro and in vivo. Polymerized hexoxyethyl cyanoacrylate was more elastic than its commercially available and widely used alkyl analog 2-octyl cyanoacrylate, without compromising biocompatibility.
Author List
Mizrahi B, Stefanescu CF, Yang C, Lawlor MW, Ko D, Langer R, Kohane DSAuthor
Michael W. Lawlor MD, PhD Adjunct Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdhesivenessAnimals
Cell Death
Cell Survival
Cyanoacrylates
Elasticity
Formaldehyde
HeLa Cells
Humans
Magnetic Resonance Spectroscopy
Male
Materials Testing
Polymerization
Rats
Rats, Sprague-Dawley
Tissue Adhesives
