The Lifespan Human Connectome Project in Development: A large-scale study of brain connectivity development in 5-21 year olds. Neuroimage 2018 Dec;183:456-468
Date
08/25/2018Pubmed ID
30142446Pubmed Central ID
PMC6416053DOI
10.1016/j.neuroimage.2018.08.050Scopus ID
2-s2.0-85052249147 (requires institutional sign-in at Scopus site) 122 CitationsAbstract
Recent technological and analytical progress in brain imaging has enabled the examination of brain organization and connectivity at unprecedented levels of detail. The Human Connectome Project in Development (HCP-D) is exploiting these tools to chart developmental changes in brain connectivity. When complete, the HCP-D will comprise approximately ∼1750 open access datasets from 1300 + healthy human participants, ages 5-21 years, acquired at four sites across the USA. The participants are from diverse geographical, ethnic, and socioeconomic backgrounds. While most participants are tested once, others take part in a three-wave longitudinal component focused on the pubertal period (ages 9-17 years). Brain imaging sessions are acquired on a 3 T Siemens Prisma platform and include structural, functional (resting state and task-based), diffusion, and perfusion imaging, physiological monitoring, and a battery of cognitive tasks and self-reports. For minors, parents additionally complete a battery of instruments to characterize cognitive and emotional development, and environmental variables relevant to development. Participants provide biological samples of blood, saliva, and hair, enabling assays of pubertal hormones, health markers, and banked DNA samples. This paper outlines the overarching aims of the project, the approach taken to acquire maximally informative data while minimizing participant burden, preliminary analyses, and discussion of the intended uses and limitations of the dataset.
Author List
Somerville LH, Bookheimer SY, Buckner RL, Burgess GC, Curtiss SW, Dapretto M, Elam JS, Gaffrey MS, Harms MP, Hodge C, Kandala S, Kastman EK, Nichols TE, Schlaggar BL, Smith SM, Thomas KM, Yacoub E, Van Essen DC, Barch DMAuthor
Michael S. Gaffrey PhD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Brain
Child
Child, Preschool
Clinical Protocols
Connectome
Datasets as Topic
Female
Human Development
Humans
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Young Adult
